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Potent antiviral effect of silver nanoparticles on SARS-CoV-2.
Biochem Biophys Res Commun. 2020 11 26; 533(1):195-200.BB

Abstract

The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed.

Authors+Show Affiliations

Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan.Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan.Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan.Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan; Life Science Laboratory, Technology and Development Division, Kanto Chemical Co., Inc., Kanagawa, 259-1146, Japan.Department of Microbiology, Yokohama City University School of Medicine, Kanagawa, 236-0004, Japan. Electronic address: aryo@yokohama-cu.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32958250

Citation

Jeremiah, Sundararaj S., et al. "Potent Antiviral Effect of Silver Nanoparticles On SARS-CoV-2." Biochemical and Biophysical Research Communications, vol. 533, no. 1, 2020, pp. 195-200.
Jeremiah SS, Miyakawa K, Morita T, et al. Potent antiviral effect of silver nanoparticles on SARS-CoV-2. Biochem Biophys Res Commun. 2020;533(1):195-200.
Jeremiah, S. S., Miyakawa, K., Morita, T., Yamaoka, Y., & Ryo, A. (2020). Potent antiviral effect of silver nanoparticles on SARS-CoV-2. Biochemical and Biophysical Research Communications, 533(1), 195-200. https://doi.org/10.1016/j.bbrc.2020.09.018
Jeremiah SS, et al. Potent Antiviral Effect of Silver Nanoparticles On SARS-CoV-2. Biochem Biophys Res Commun. 2020 11 26;533(1):195-200. PubMed PMID: 32958250.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potent antiviral effect of silver nanoparticles on SARS-CoV-2. AU - Jeremiah,Sundararaj S, AU - Miyakawa,Kei, AU - Morita,Takeshi, AU - Yamaoka,Yutaro, AU - Ryo,Akihide, Y1 - 2020/09/11/ PY - 2020/09/04/received PY - 2020/09/08/accepted PY - 2020/9/23/pubmed PY - 2020/10/30/medline PY - 2020/9/22/entrez KW - COVID-19 KW - Colloidal silver KW - SARS-CoV-2 KW - Silver nanoparticles SP - 195 EP - 200 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 533 IS - 1 N2 - The pandemic of COVID-19 is spreading unchecked due to the lack of effective antiviral measures. Silver nanoparticles (AgNP) have been studied to possess antiviral properties and are presumed to inhibit SARS-CoV-2. Due to the need for an effective agent against SARS-CoV-2, we evaluated the antiviral effect of AgNPs. We evaluated a plethora of AgNPs of different sizes and concentration and observed that particles of diameter around 10 nm were effective in inhibiting extracellular SARS-CoV-2 at concentrations ranging between 1 and 10 ppm while cytotoxic effect was observed at concentrations of 20 ppm and above. Luciferase-based pseudovirus entry assay revealed that AgNPs potently inhibited viral entry step via disrupting viral integrity. These results indicate that AgNPs are highly potent microbicides against SARS-CoV-2 but should be used with caution due to their cytotoxic effects and their potential to derange environmental ecosystems when improperly disposed. SN - 1090-2104 UR - https://www.unboundmedicine.com/medline/citation/32958250/Potent_antiviral_effect_of_silver_nanoparticles_on_SARS-CoV-2 L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(20)31757-5 DB - PRIME DP - Unbound Medicine ER -