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Thrombo-inflammatory features predicting mortality in patients with COVID-19: The FAD-85 score.
J Int Med Res. 2020 Sep; 48(9):300060520955037.JI

Abstract

BACKGROUND

The roles of inflammation and hypercoagulation in predicting outcomes of coronavirus disease 2019 (COVID-19) are unclear.

METHODS

Adult patients diagnosed with COVID-19 from 28 January 2020 to 4 March 2020 in Tongji Hospital, Wuhan were recruited. Data on related parameters were collected. Univariate analysis and multivariable binary logistic regression were used to explore predictors of critical illness and mortality.

RESULTS

In total, 199 and 44 patients were enrolled in the training and testing sets, respectively. Elevated ferritin, tumor necrosis factor-α and D-dimer and decreased albumin concentration were associated with disease severity. Older age, elevated ferritin and elevated interleukin-6 were associated with 28-day mortality. The FAD-85 score, defined as age + 0.01 * ferritin +D-dimer, was used to predict risk of mortality. The sensitivity, specificity and accuracy of FAD-85 were 86.4%, 81.8% and 86.4%, respectively. A nomogram was established using age, ferritin and D-dimer to predict the risk of 28-day mortality.

CONCLUSIONS

Thrombo-inflammatory parameters provide key information on the severity and prognosis of COVID-19 and can be used as references for clinical treatment to correct inflammatory and coagulation abnormalities.

Authors+Show Affiliations

Emergency Department, Peking University Third Hospital, Beijing, China.Clinical Epidemiology Research Center, Peking University Third Hospital, Beijing, China.Department of Clinical Laboratory Medicine, Peking University Third Hospital, Beijing, China.Department of Critical Care Medicine, Peking University Third Hospital, Beijing, China.Department of General Surgery, Peking University Third Hospital, Beijing, China.The Third School of Clinical Medicine, Peking University, Beijing, China.Emergency Department, Peking University Third Hospital, Beijing, China.Emergency Department, Peking University Third Hospital, Beijing, China.Department of Respiratory and Critical Medicine, Peking University Third Hospital, Beijing, China.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

32960106

Citation

Wang, Junhong, et al. "Thrombo-inflammatory Features Predicting Mortality in Patients With COVID-19: the FAD-85 Score." The Journal of International Medical Research, vol. 48, no. 9, 2020, p. 300060520955037.
Wang J, Zhang H, Qiao R, et al. Thrombo-inflammatory features predicting mortality in patients with COVID-19: The FAD-85 score. J Int Med Res. 2020;48(9):300060520955037.
Wang, J., Zhang, H., Qiao, R., Ge, Q., Zhang, S., Zhao, Z., Tian, C., Ma, Q., & Shen, N. (2020). Thrombo-inflammatory features predicting mortality in patients with COVID-19: The FAD-85 score. The Journal of International Medical Research, 48(9), 300060520955037. https://doi.org/10.1177/0300060520955037
Wang J, et al. Thrombo-inflammatory Features Predicting Mortality in Patients With COVID-19: the FAD-85 Score. J Int Med Res. 2020;48(9):300060520955037. PubMed PMID: 32960106.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thrombo-inflammatory features predicting mortality in patients with COVID-19: The FAD-85 score. AU - Wang,Junhong, AU - Zhang,Hua, AU - Qiao,Rui, AU - Ge,Qinggang, AU - Zhang,Shuisheng, AU - Zhao,Zongxuan, AU - Tian,Ci, AU - Ma,Qingbian, AU - Shen,Ning, PY - 2020/9/22/entrez PY - 2020/9/23/pubmed PY - 2020/10/2/medline KW - COVID-19 KW - coagulation KW - inflammation KW - model KW - mortality KW - predictor SP - 300060520955037 EP - 300060520955037 JF - The Journal of international medical research JO - J Int Med Res VL - 48 IS - 9 N2 - BACKGROUND: The roles of inflammation and hypercoagulation in predicting outcomes of coronavirus disease 2019 (COVID-19) are unclear. METHODS: Adult patients diagnosed with COVID-19 from 28 January 2020 to 4 March 2020 in Tongji Hospital, Wuhan were recruited. Data on related parameters were collected. Univariate analysis and multivariable binary logistic regression were used to explore predictors of critical illness and mortality. RESULTS: In total, 199 and 44 patients were enrolled in the training and testing sets, respectively. Elevated ferritin, tumor necrosis factor-α and D-dimer and decreased albumin concentration were associated with disease severity. Older age, elevated ferritin and elevated interleukin-6 were associated with 28-day mortality. The FAD-85 score, defined as age + 0.01 * ferritin +D-dimer, was used to predict risk of mortality. The sensitivity, specificity and accuracy of FAD-85 were 86.4%, 81.8% and 86.4%, respectively. A nomogram was established using age, ferritin and D-dimer to predict the risk of 28-day mortality. CONCLUSIONS: Thrombo-inflammatory parameters provide key information on the severity and prognosis of COVID-19 and can be used as references for clinical treatment to correct inflammatory and coagulation abnormalities. SN - 1473-2300 UR - https://www.unboundmedicine.com/medline/citation/32960106/Thrombo_inflammatory_features_predicting_mortality_in_patients_with_COVID_19:_The_FAD_85_score_ L2 - https://journals.sagepub.com/doi/10.1177/0300060520955037?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -