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Interaction between age and vitamin D deficiency in severe COVID-19 infection.
Nutr Hosp. 2020 Oct 21; 37(5):1039-1042.NH

Abstract

INTRODUCTION

Background: coronavirus disease 2019 (COVID-19) can induce an exaggerated inflammatory response. Vitamin D is a key modulator of the immune system. We hypothesized that vitamin D deficiency (VDD) could increase the risk of developing severe COVID-19 infection. Methods: patients with confirmed COVID-19 seen at the emergency department of our hospital with recent measurements of 25(OH)D were recruited. We explored the association of vitamin D deficiency (VDD), defined as 25-hydroxyvitamin D < 20 ng/mL, with a composite of adverse clinical outcomes. Results: we included 80 patients, of which 31 (39 %) presented the endpoint. VDD tended to predict an increased risk of developing severe COVID-19 after adjusting for age, gender, obesity, cardiac disease, and kidney disease [OR 3.2 (95 % CI: 0.9-11.4), p = 0.07]. Age had a negative interaction with the effect of VDD on the composite outcome (p = 0.03), indicating that the effect was more noticeable at younger ages. Furthermore, male gender was associated with VDD and with severe COVID-19 at younger ages. Conclusions: in this retrospective study, vitamin D deficiency showed a signal of association with severe COVID-19 infection. A significant interaction with age was noted, suggesting VDD may have a greater impact in younger patients. These findings should be confirmed in larger, prospective, adequately powered studies.

Authors+Show Affiliations

Hospital Clínico San Carlos.Hospital Clínico San Carlos.Hospital Clínico San Carlos.Hospital Clínico San Carlos.Hospital Clínico San Carlos.Hospital Clínico San Carlos.Hospital Clínico San Carlos.Hospital Clínico San Carlos.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32960622

Citation

Macaya, Fernando, et al. "Interaction Between Age and Vitamin D Deficiency in Severe COVID-19 Infection." Nutricion Hospitalaria, vol. 37, no. 5, 2020, pp. 1039-1042.
Macaya F, Espejo Paeres C, Valls A, et al. Interaction between age and vitamin D deficiency in severe COVID-19 infection. Nutr Hosp. 2020;37(5):1039-1042.
Macaya, F., Espejo Paeres, C., Valls, A., Fernández-Ortiz, A., González Del Castillo, J., Martín-Sánchez, F. J., Runkle, I., & Rubio Herrera, M. Á. (2020). Interaction between age and vitamin D deficiency in severe COVID-19 infection. Nutricion Hospitalaria, 37(5), 1039-1042. https://doi.org/10.20960/nh.03193
Macaya F, et al. Interaction Between Age and Vitamin D Deficiency in Severe COVID-19 Infection. Nutr Hosp. 2020 Oct 21;37(5):1039-1042. PubMed PMID: 32960622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between age and vitamin D deficiency in severe COVID-19 infection. AU - Macaya,Fernando, AU - Espejo Paeres,Carolina, AU - Valls,Adrián, AU - Fernández-Ortiz,Antonio, AU - González Del Castillo,Juan, AU - Martín-Sánchez,F Javier, AU - Runkle,Isabelle, AU - Rubio Herrera,Miguel Ángel, PY - 2020/9/23/pubmed PY - 2020/10/29/medline PY - 2020/9/22/entrez KW - COVID-19. Síndrome de distrés respiratorio grave. Déficit de vitamina D. Enzima convertidora de angiotesina 2. SP - 1039 EP - 1042 JF - Nutricion hospitalaria JO - Nutr Hosp VL - 37 IS - 5 N2 - INTRODUCTION: Background: coronavirus disease 2019 (COVID-19) can induce an exaggerated inflammatory response. Vitamin D is a key modulator of the immune system. We hypothesized that vitamin D deficiency (VDD) could increase the risk of developing severe COVID-19 infection. Methods: patients with confirmed COVID-19 seen at the emergency department of our hospital with recent measurements of 25(OH)D were recruited. We explored the association of vitamin D deficiency (VDD), defined as 25-hydroxyvitamin D < 20 ng/mL, with a composite of adverse clinical outcomes. Results: we included 80 patients, of which 31 (39 %) presented the endpoint. VDD tended to predict an increased risk of developing severe COVID-19 after adjusting for age, gender, obesity, cardiac disease, and kidney disease [OR 3.2 (95 % CI: 0.9-11.4), p = 0.07]. Age had a negative interaction with the effect of VDD on the composite outcome (p = 0.03), indicating that the effect was more noticeable at younger ages. Furthermore, male gender was associated with VDD and with severe COVID-19 at younger ages. Conclusions: in this retrospective study, vitamin D deficiency showed a signal of association with severe COVID-19 infection. A significant interaction with age was noted, suggesting VDD may have a greater impact in younger patients. These findings should be confirmed in larger, prospective, adequately powered studies. SN - 1699-5198 UR - https://www.unboundmedicine.com/medline/citation/32960622/Interaction_between_age_and_vitamin_D_deficiency_in_severe_COVID_19_infection_ L2 - https://www.nutricionhospitalaria.org/articles/03193/show DB - PRIME DP - Unbound Medicine ER -