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Assessment and mitigation of aerosol airborne SARS-CoV-2 transmission in laboratory and office environments.
J Occup Environ Hyg. 2020 10; 17(10):447-456.JO

Abstract

Bioaerosols are known to be an important transmission pathway for SARS-CoV-2. We report a framework for estimating the risk of transmitting SARS-CoV-2 via aerosols in laboratory and office settings, based on an exponential dose-response model and analysis of air flow and purification in typical heating, ventilation, and air conditioning (HVAC) systems. High-circulation HVAC systems with high-efficiency particulate air (HEPA) filtration dramatically reduce exposure to the virus in indoor settings, and surgical masks or N95 respirators further reduce exposure. As an example of our risk assessment model, we consider the precautions needed for a typical experimental physical science group to maintain a low risk of transmission over six months of operation. We recommend that, for environments where fewer than five individuals significantly overlap, work spaces should remain vacant for between one (high-circulation HVAC with HEPA filtration) to six (low-circulation HVAC with no filtration) air exchange times before a new worker enters in order to maintain no more than 1% chance of infection over six months of operation in the workplace. Our model is readily applied to similar settings that are not explicitly given here. We also provide a framework for evaluating infection mitigation through ventilation in multiple occupancy spaces.

Authors+Show Affiliations

Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.Department of Physics, Harvard University, Cambridge, Massachusetts, USA. Harvard-MIT Center for Ultracold Atoms, Cambridge, Massachusetts, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32960737

Citation

Augenbraun, Benjamin L., et al. "Assessment and Mitigation of Aerosol Airborne SARS-CoV-2 Transmission in Laboratory and Office Environments." Journal of Occupational and Environmental Hygiene, vol. 17, no. 10, 2020, pp. 447-456.
Augenbraun BL, Lasner ZD, Mitra D, et al. Assessment and mitigation of aerosol airborne SARS-CoV-2 transmission in laboratory and office environments. J Occup Environ Hyg. 2020;17(10):447-456.
Augenbraun, B. L., Lasner, Z. D., Mitra, D., Prabhu, S., Raval, S., Sawaoka, H., & Doyle, J. M. (2020). Assessment and mitigation of aerosol airborne SARS-CoV-2 transmission in laboratory and office environments. Journal of Occupational and Environmental Hygiene, 17(10), 447-456. https://doi.org/10.1080/15459624.2020.1805117
Augenbraun BL, et al. Assessment and Mitigation of Aerosol Airborne SARS-CoV-2 Transmission in Laboratory and Office Environments. J Occup Environ Hyg. 2020;17(10):447-456. PubMed PMID: 32960737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment and mitigation of aerosol airborne SARS-CoV-2 transmission in laboratory and office environments. AU - Augenbraun,Benjamin L, AU - Lasner,Zack D, AU - Mitra,Debayan, AU - Prabhu,Sridhar, AU - Raval,Shivam, AU - Sawaoka,Hiromitsu, AU - Doyle,John M, Y1 - 2020/09/22/ PY - 2020/9/23/pubmed PY - 2020/10/21/medline PY - 2020/9/22/entrez KW - Airborne viral transmission KW - SARS-CoV-2 KW - coronavirus KW - risk analysis SP - 447 EP - 456 JF - Journal of occupational and environmental hygiene JO - J Occup Environ Hyg VL - 17 IS - 10 N2 - Bioaerosols are known to be an important transmission pathway for SARS-CoV-2. We report a framework for estimating the risk of transmitting SARS-CoV-2 via aerosols in laboratory and office settings, based on an exponential dose-response model and analysis of air flow and purification in typical heating, ventilation, and air conditioning (HVAC) systems. High-circulation HVAC systems with high-efficiency particulate air (HEPA) filtration dramatically reduce exposure to the virus in indoor settings, and surgical masks or N95 respirators further reduce exposure. As an example of our risk assessment model, we consider the precautions needed for a typical experimental physical science group to maintain a low risk of transmission over six months of operation. We recommend that, for environments where fewer than five individuals significantly overlap, work spaces should remain vacant for between one (high-circulation HVAC with HEPA filtration) to six (low-circulation HVAC with no filtration) air exchange times before a new worker enters in order to maintain no more than 1% chance of infection over six months of operation in the workplace. Our model is readily applied to similar settings that are not explicitly given here. We also provide a framework for evaluating infection mitigation through ventilation in multiple occupancy spaces. SN - 1545-9632 UR - https://www.unboundmedicine.com/medline/citation/32960737/Assessment_and_mitigation_of_aerosol_airborne_SARS_CoV_2_transmission_in_laboratory_and_office_environments_ L2 - https://www.tandfonline.com/doi/full/10.1080/15459624.2020.1805117 DB - PRIME DP - Unbound Medicine ER -