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Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines.
Open Biol. 2020 09; 10(9):200160.OB

Abstract

Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; disease prognosis is influenced mainly by multi-organ involvement. Acute respiratory distress syndrome, heart failure, renal failure, liver damage, shock and multi-organ failure are strongly associated with morbidity and mortality. The COVID-19 disease pathology is plausibly linked to the hyperinflammatory response of the body characterized by pathological cytokine levels. The term 'cytokine storm syndrome' is perhaps one of the critical hallmarks of COVID-19 disease severity. In this review, we highlight prominent cytokine families and their potential role in COVID-19, the type I and II interferons, tumour necrosis factor and members of the Interleukin family. We address various changes in cellular components of the immune response corroborating with changes in cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokine storm.

Authors+Show Affiliations

Independent researcher, unaffiliated.Department of Clinical Research, Zan Mitrev Clinic, St. Bledski Dogovor 8, 1000 Skopje, The Republic of North Macedonia.Department of Clinical Research, Zan Mitrev Clinic, St. Bledski Dogovor 8, 1000 Skopje, The Republic of North Macedonia.Faculty of Applied Medical Sciences, Department of Medical Laboratory Technology, Immunology group, King Abdul Aziz University, Jeddah, Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32961074

Citation

Fara, Antonella, et al. "Cytokine Storm and COVID-19: a Chronicle of Pro-inflammatory Cytokines." Open Biology, vol. 10, no. 9, 2020, p. 200160.
Fara A, Mitrev Z, Rosalia RA, et al. Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. Open Biol. 2020;10(9):200160.
Fara, A., Mitrev, Z., Rosalia, R. A., & Assas, B. M. (2020). Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. Open Biology, 10(9), 200160. https://doi.org/10.1098/rsob.200160
Fara A, et al. Cytokine Storm and COVID-19: a Chronicle of Pro-inflammatory Cytokines. Open Biol. 2020;10(9):200160. PubMed PMID: 32961074.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokine storm and COVID-19: a chronicle of pro-inflammatory cytokines. AU - Fara,Antonella, AU - Mitrev,Zan, AU - Rosalia,Rodney Alexander, AU - Assas,Bakri M, Y1 - 2020/09/23/ PY - 2020/9/22/entrez PY - 2020/9/23/pubmed PY - 2020/10/6/medline KW - COVID-19 KW - IFN-γ KW - IL-6 KW - SARS KW - TNF-α KW - coronavirus SP - 200160 EP - 200160 JF - Open biology JO - Open Biol VL - 10 IS - 9 N2 - Coronavirus disease 2019 (COVID-19) has swept the world, unlike any other pandemic in the last 50 years. Our understanding of the disease has evolved rapidly since the outbreak; disease prognosis is influenced mainly by multi-organ involvement. Acute respiratory distress syndrome, heart failure, renal failure, liver damage, shock and multi-organ failure are strongly associated with morbidity and mortality. The COVID-19 disease pathology is plausibly linked to the hyperinflammatory response of the body characterized by pathological cytokine levels. The term 'cytokine storm syndrome' is perhaps one of the critical hallmarks of COVID-19 disease severity. In this review, we highlight prominent cytokine families and their potential role in COVID-19, the type I and II interferons, tumour necrosis factor and members of the Interleukin family. We address various changes in cellular components of the immune response corroborating with changes in cytokine levels while discussing cytokine sources and biological functions. Finally, we discuss in brief potential therapies attempting to modulate the cytokine storm. SN - 2046-2441 UR - https://www.unboundmedicine.com/medline/citation/32961074/Cytokine_storm_and_COVID_19:_a_chronicle_of_pro_inflammatory_cytokines_ L2 - https://royalsocietypublishing.org/doi/10.1098/rsob.200160?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -