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Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2.
Curr Top Med Chem. 2020; 20(26):2362-2378.CT

Abstract

The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARS-CoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a Receptor-binding Domain (RBD) that mediates the binding to host cell receptor, Angiotensin Converting Enzyme 2 (ACE2). The article details the repurposing of some drugs to be tried for COVID-19 and presents the status of vaccine development so far. Besides drugs and vaccines, the role of Convalescent Plasma (CP) therapy to treat COVID-19 is also discussed.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Gupta SP
Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut-250005, India.

MeSH

Adenosine MonophosphateAlanineAngiotensin-Converting Enzyme 2Antiviral AgentsBetacoronavirusCOVID-19COVID-19 VaccinesCoronavirus InfectionsGene ExpressionHost-Pathogen InteractionsHumansHydroxychloroquineImmunization, PassiveIvermectinModels, MolecularNiclosamidePandemicsPeptidyl-Dipeptidase APneumonia, ViralProtein Interaction Domains and MotifsProtein Structure, SecondarySevere acute respiratory syndrome-related coronavirusSARS-CoV-2Severe Acute Respiratory SyndromeSpike Glycoprotein, CoronavirusViral VaccinesCOVID-19 Serotherapy

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32962613

Citation

Gupta, Satya P.. "Progress in Studies On Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2." Current Topics in Medicinal Chemistry, vol. 20, no. 26, 2020, pp. 2362-2378.
Gupta SP. Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2. Curr Top Med Chem. 2020;20(26):2362-2378.
Gupta, S. P. (2020). Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2. Current Topics in Medicinal Chemistry, 20(26), 2362-2378. https://doi.org/10.2174/1568026620666200922112300
Gupta SP. Progress in Studies On Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2. Curr Top Med Chem. 2020;20(26):2362-2378. PubMed PMID: 32962613.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progress in Studies on Structural and Remedial Aspects of Newly Born Coronavirus, SARS-CoV-2. A1 - Gupta,Satya P, PY - 2020/6/26/received PY - 2020/8/10/revised PY - 2020/9/1/accepted PY - 2020/9/24/pubmed PY - 2020/11/20/medline PY - 2020/9/23/entrez KW - 2019-CoV-2 KW - Anti-COVID-19 drugs KW - Antibodies KW - COVID-19 KW - Convalescent plasma (CP) therapy KW - Epitopes KW - Vaccines SP - 2362 EP - 2378 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 20 IS - 26 N2 - The article highlights an up-to-date progress in studies on structural and the remedial aspects of novel coronavirus 2019-nCoV, renamed as SARS-CoV-2, leading to the disease COVID-19, a pandemic. In general, all CoVs including SARS-CoV-2 are spherical positive single-stranded RNA viruses containing spike (S) protein, envelope (E) protein, nucleocapsid (N) protein, and membrane (M) protein, where S protein has a Receptor-binding Domain (RBD) that mediates the binding to host cell receptor, Angiotensin Converting Enzyme 2 (ACE2). The article details the repurposing of some drugs to be tried for COVID-19 and presents the status of vaccine development so far. Besides drugs and vaccines, the role of Convalescent Plasma (CP) therapy to treat COVID-19 is also discussed. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/32962613/Progress_in_Studies_on_Structural_and_Remedial_Aspects_of_Newly_Born_Coronavirus_SARS_CoV_2_ DB - PRIME DP - Unbound Medicine ER -