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Severe COVID-19: what have we learned with the immunopathogenesis?
Adv Rheumatol. 2020 09 22; 60(1):50.AR

Abstract

The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global major concern. In this review, we addressed a theoretical model on immunopathogenesis associated with severe COVID-19, based on the current literature of SARS-CoV-2 and other epidemic pathogenic coronaviruses, such as SARS and MERS. Several studies have suggested that immune dysregulation and hyperinflammatory response induced by SARS-CoV-2 are more involved in disease severity than the virus itself.Immune dysregulation due to COVID-19 is characterized by delayed and impaired interferon response, lymphocyte exhaustion and cytokine storm that ultimately lead to diffuse lung tissue damage and posterior thrombotic phenomena.Considering there is a lack of clinical evidence provided by randomized clinical trials, the knowledge about SARS-CoV-2 disease pathogenesis and immune response is a cornerstone to develop rationale-based clinical therapeutic strategies. In this narrative review, the authors aimed to describe the immunopathogenesis of severe forms of COVID-19.

Authors+Show Affiliations

Departament of Internal Medicine / Emergence, Hospital Universitário Antônio Pedro / Univesidade Federal Fluminense, Niterói, RJ, Brazil. brunobaf@hotmail.com.Departament of Internal Medicine / Emergence, Hospital Universitário Antônio Pedro / Universidade Federal Fluminense, Niterói, RJ, Brazil.Hospital Universitário Gaffré e Guinle / Universidade Federal do Estado do Rio de Janeiro, Internal Medicine Departament, Rio de Janeiro, RJ, Brazil.Departament of Internal Medicine, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, RJ, Brazil.Departament of Rheumatology, Universidade Federal de São Paulo, Sao Paulo, SP, Brazil.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32962761

Citation

Bordallo, Bruno, et al. "Severe COVID-19: what Have We Learned With the Immunopathogenesis?" Advances in Rheumatology (London, England), vol. 60, no. 1, 2020, p. 50.
Bordallo B, Bellas M, Cortez AF, et al. Severe COVID-19: what have we learned with the immunopathogenesis? Adv Rheumatol. 2020;60(1):50.
Bordallo, B., Bellas, M., Cortez, A. F., Vieira, M., & Pinheiro, M. (2020). Severe COVID-19: what have we learned with the immunopathogenesis? Advances in Rheumatology (London, England), 60(1), 50. https://doi.org/10.1186/s42358-020-00151-7
Bordallo B, et al. Severe COVID-19: what Have We Learned With the Immunopathogenesis. Adv Rheumatol. 2020 09 22;60(1):50. PubMed PMID: 32962761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Severe COVID-19: what have we learned with the immunopathogenesis? AU - Bordallo,Bruno, AU - Bellas,Mozart, AU - Cortez,Arthur Fernandes, AU - Vieira,Matheus, AU - Pinheiro,Marcelo, Y1 - 2020/09/22/ PY - 2020/06/18/received PY - 2020/09/07/accepted PY - 2020/9/23/entrez PY - 2020/9/24/pubmed PY - 2020/10/8/medline KW - COVID-19 KW - Cytokine KW - Cytokine storm KW - Immunology KW - Inflammation KW - Macrophage activation syndrome KW - SARS-CoV-2 KW - Thrombosis SP - 50 EP - 50 JF - Advances in rheumatology (London, England) JO - Adv Rheumatol VL - 60 IS - 1 N2 - The COVID-19 outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global major concern. In this review, we addressed a theoretical model on immunopathogenesis associated with severe COVID-19, based on the current literature of SARS-CoV-2 and other epidemic pathogenic coronaviruses, such as SARS and MERS. Several studies have suggested that immune dysregulation and hyperinflammatory response induced by SARS-CoV-2 are more involved in disease severity than the virus itself.Immune dysregulation due to COVID-19 is characterized by delayed and impaired interferon response, lymphocyte exhaustion and cytokine storm that ultimately lead to diffuse lung tissue damage and posterior thrombotic phenomena.Considering there is a lack of clinical evidence provided by randomized clinical trials, the knowledge about SARS-CoV-2 disease pathogenesis and immune response is a cornerstone to develop rationale-based clinical therapeutic strategies. In this narrative review, the authors aimed to describe the immunopathogenesis of severe forms of COVID-19. SN - 2523-3106 UR - https://www.unboundmedicine.com/medline/citation/32962761/Severe_COVID_19:_what_have_we_learned_with_the_immunopathogenesis L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/32962761/ DB - PRIME DP - Unbound Medicine ER -