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An association between exposure to Middle East Respiratory Syndrome (MERS) and mortality rate of Coronavirus Disease 2019 (COVID-19).
Eur Rev Med Pharmacol Sci. 2020 Sep; 24(17):9172-9181.ER

Abstract

OBJECTIVE

Our objective was to find an association between exposure of a population to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and mortality rate due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) across different countries worldwide.

MATERIALS AND METHODS

To find the relationship between exposure to MERS-CoV and mortality rate due to SARS-CoV-2, we collected and analyzed data of three possible factors that may have resulted in an exposure of a population to MERS-CoV: (1) the number of Middle East Respiratory Syndrome (MERS) cases reported among 16 countries since 2012; (2) data of MERS-CoV seroprevalence in camels across 23 countries, as working with camels increase risk of exposure to MERS-CoV; (3) data of travel history of people from 51 countries to Saudi Arabia was collected on the assumption that travel to a country where MERS is endemic, such as, Saudi Arabia, could also lead to exposure to MERS-CoV.

RESULTS

We found a significantly lower number of Coronavirus disease 2019 (COVID-19) deaths per million (deaths/M) of a population in countries that are likely to be exposed to MERS-CoV than otherwise (t-stat=3.686, p<0.01). In addition, the number of COVID-19 deaths/M of a population was significantly lower in countries that reported a higher seroprevalence of MERS-CoV in camels than otherwise (t-stat=4.5077, p<0.01). Regression analysis showed that increased travelling history to Saudi Arabia is likely to be associated with a lower mortality rate due to COVID-19.

CONCLUSIONS

This study provides empirical evidence that a population that was at an increased risk of exposure to MERS-CoV had a significantly lower mortality rate due to SARS-CoV-2, which might be due to cross-protective immunity against SARS-CoV-2 in that population because of an earlier exposure to MERS-CoV.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Naeem U
Department of Health Professional Technology, University of Lahore, Lahore, Pakistan. paknephrologist@hotmail.com.
Naeem A
No affiliation info available
Naeem MA
No affiliation info available
Naeem K
No affiliation info available
Mujtaba B
No affiliation info available
Mujtaba A
No affiliation info available
Khurshid A
No affiliation info available

MeSH

BetacoronavirusCOVID-19Coronavirus InfectionsHumansPandemicsPneumonia, ViralPrevalenceRegression AnalysisSARS-CoV-2Seroepidemiologic StudiesSurvival Rate

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32965011

Citation

Naeem, U, et al. "An Association Between Exposure to Middle East Respiratory Syndrome (MERS) and Mortality Rate of Coronavirus Disease 2019 (COVID-19)." European Review for Medical and Pharmacological Sciences, vol. 24, no. 17, 2020, pp. 9172-9181.
Naeem U, Naeem A, Naeem MA, et al. An association between exposure to Middle East Respiratory Syndrome (MERS) and mortality rate of Coronavirus Disease 2019 (COVID-19). Eur Rev Med Pharmacol Sci. 2020;24(17):9172-9181.
Naeem, U., Naeem, A., Naeem, M. A., Naeem, K., Mujtaba, B., Mujtaba, A., & Khurshid, A. (2020). An association between exposure to Middle East Respiratory Syndrome (MERS) and mortality rate of Coronavirus Disease 2019 (COVID-19). European Review for Medical and Pharmacological Sciences, 24(17), 9172-9181. https://doi.org/10.26355/eurrev_202009_22868
Naeem U, et al. An Association Between Exposure to Middle East Respiratory Syndrome (MERS) and Mortality Rate of Coronavirus Disease 2019 (COVID-19). Eur Rev Med Pharmacol Sci. 2020;24(17):9172-9181. PubMed PMID: 32965011.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An association between exposure to Middle East Respiratory Syndrome (MERS) and mortality rate of Coronavirus Disease 2019 (COVID-19). AU - Naeem,U, AU - Naeem,A, AU - Naeem,M A, AU - Naeem,K, AU - Mujtaba,B, AU - Mujtaba,A, AU - Khurshid,A, PY - 2020/9/23/entrez PY - 2020/9/24/pubmed PY - 2020/10/2/medline SP - 9172 EP - 9181 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 24 IS - 17 N2 - OBJECTIVE: Our objective was to find an association between exposure of a population to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) and mortality rate due to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) across different countries worldwide. MATERIALS AND METHODS: To find the relationship between exposure to MERS-CoV and mortality rate due to SARS-CoV-2, we collected and analyzed data of three possible factors that may have resulted in an exposure of a population to MERS-CoV: (1) the number of Middle East Respiratory Syndrome (MERS) cases reported among 16 countries since 2012; (2) data of MERS-CoV seroprevalence in camels across 23 countries, as working with camels increase risk of exposure to MERS-CoV; (3) data of travel history of people from 51 countries to Saudi Arabia was collected on the assumption that travel to a country where MERS is endemic, such as, Saudi Arabia, could also lead to exposure to MERS-CoV. RESULTS: We found a significantly lower number of Coronavirus disease 2019 (COVID-19) deaths per million (deaths/M) of a population in countries that are likely to be exposed to MERS-CoV than otherwise (t-stat=3.686, p<0.01). In addition, the number of COVID-19 deaths/M of a population was significantly lower in countries that reported a higher seroprevalence of MERS-CoV in camels than otherwise (t-stat=4.5077, p<0.01). Regression analysis showed that increased travelling history to Saudi Arabia is likely to be associated with a lower mortality rate due to COVID-19. CONCLUSIONS: This study provides empirical evidence that a population that was at an increased risk of exposure to MERS-CoV had a significantly lower mortality rate due to SARS-CoV-2, which might be due to cross-protective immunity against SARS-CoV-2 in that population because of an earlier exposure to MERS-CoV. SN - 2284-0729 UR - https://www.unboundmedicine.com/medline/citation/32965011/An_association_between_exposure_to_Middle_East_Respiratory_Syndrome__MERS__and_mortality_rate_of_Coronavirus_Disease_2019__COVID_19__ DB - PRIME DP - Unbound Medicine ER -