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Renal changes and acute kidney injury in covid-19: a systematic review.
Rev Assoc Med Bras (1992). 2020; 66Suppl 2(Suppl 2):112-117.RA

Abstract

OBJECTIVE

We aimed to present a review of renal changes in patients with COVID-19.

METHODS

We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords "COVID-19", "coronavirus", "SARS-CoV-2", "kidney injury" and "kidney disease". Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes.

DISCUSSION

Acute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys.

CONCLUSION

Although COVID-19 affects mainly the lungs, it can also impact the kidneys. Increased serum creatinine and BUN, hematuria, proteinuria, and AKI were frequent findings in patients with severe COVID-19 and were related to an increased mortality rate. Further studies focusing on renal changes and their implications for the clinical condition of patients infected with the novel coronavirus are needed.

Authors+Show Affiliations

. Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.. Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.. Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.. Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.. Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.. Universidade de Fortaleza, Curso de Medicina, Programas de Pós-Graduação em Saúde Coletiva e Ciências Médicas, Fortaleza, CE, Brasil.. Universidade Federal do Cariri, Faculdade de Medicina, Barbalha, CE, Brasil.

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

32965368

Citation

Nogueira, Samuel Átila Rodrigues, et al. "Renal Changes and Acute Kidney Injury in Covid-19: a Systematic Review." Revista Da Associacao Medica Brasileira (1992), vol. 66Suppl 2, no. Suppl 2, 2020, pp. 112-117.
Nogueira SÁR, Oliveira SCS, Carvalho AFM, et al. Renal changes and acute kidney injury in covid-19: a systematic review. Rev Assoc Med Bras (1992). 2020;66Suppl 2(Suppl 2):112-117.
Nogueira, S. Á. R., Oliveira, S. C. S., Carvalho, A. F. M., Neves, J. M. C., Silva, L. S. V. D., Silva Junior, G. B. D., & Nobre, M. E. P. (2020). Renal changes and acute kidney injury in covid-19: a systematic review. Revista Da Associacao Medica Brasileira (1992), 66Suppl 2(Suppl 2), 112-117. https://doi.org/10.1590/1806-9282.66.S2.112
Nogueira SÁR, et al. Renal Changes and Acute Kidney Injury in Covid-19: a Systematic Review. Rev Assoc Med Bras (1992). 2020;66Suppl 2(Suppl 2):112-117. PubMed PMID: 32965368.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Renal changes and acute kidney injury in covid-19: a systematic review. AU - Nogueira,Samuel Átila Rodrigues, AU - Oliveira,Samuel Ciríaco Silva de, AU - Carvalho,Ana Flávia Moreira de, AU - Neves,Julia Moreira Cavalcante, AU - Silva,Leila Silveira Vieira da, AU - Silva Junior,Geraldo Bezerra da, AU - Nobre,Maria Elizabeth Pereira, Y1 - 2020/09/21/ PY - 2020/06/06/received PY - 2020/06/12/accepted PY - 2020/9/23/entrez PY - 2020/9/24/pubmed PY - 2020/10/2/medline SP - 112 EP - 117 JF - Revista da Associacao Medica Brasileira (1992) JO - Rev Assoc Med Bras (1992) VL - 66Suppl 2 IS - Suppl 2 N2 - OBJECTIVE: We aimed to present a review of renal changes in patients with COVID-19. METHODS: We performed a systematic review of the literature to identify original articles regarding clinical, laboratory, and anatomopathological kidney changes in patients infected with SARS-CoV-2 published until May 7, 2020. The search was carried out across PubMed, Scopus, and Embase using the keywords "COVID-19", "coronavirus", "SARS-CoV-2", "kidney injury" and "kidney disease". Fifteen studies presented clinical and laboratory renal changes in patients with COVID-19, and three addressed anatomopathological changes. DISCUSSION: Acute kidney injury (AKI) was a relevant finding in patients with COVID-19. There were also significant changes in laboratory tests that indicated kidney injury, such as increased serum creatinine and blood urea nitrogen (BUN), proteinuria, and hematuria. The presence of laboratory abnormalities and AKI were significant in severely ill patients. There was a considerable prevalence of AKI among groups of patients who died of COVID-19. Histopathological analysis of the kidney tissue of patients infected with SARS-CoV-2 suggested that the virus may directly affect the kidneys. CONCLUSION: Although COVID-19 affects mainly the lungs, it can also impact the kidneys. Increased serum creatinine and BUN, hematuria, proteinuria, and AKI were frequent findings in patients with severe COVID-19 and were related to an increased mortality rate. Further studies focusing on renal changes and their implications for the clinical condition of patients infected with the novel coronavirus are needed. SN - 1806-9282 UR - https://www.unboundmedicine.com/medline/citation/32965368/Renal_changes_and_acute_kidney_injury_in_covid_19:_a_systematic_review_ L2 - https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302020001400112&lng=en&nrm=iso&tlng=en DB - PRIME DP - Unbound Medicine ER -