Tags

Type your tag names separated by a space and hit enter

Coronavirus global pandemic: An overview of current findings among pediatric patients.
Pediatr Pulmonol. 2020 12; 55(12):3252-3267.PP

Abstract

BACKGROUND

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic has been emerged as a cardinal public health problem. Children have their own specific clinical features; notably, they seem to be escaping the severe respiratory adverse effects. The international scientific community is rapidly carrying out studies, driving to the need to reassess knowledge of the disease and therapeutic strategies.

AIM

To assess the characteristics of COVID-19 infected children worldwide of all ages, from neonates to children and adolescents, and how they differ from their adult counterparts.

SEARCH STRATEGY

An electronic search in PubMed was conducted, using combinations of the following keywords: coronavirus, SARS-CoV-2, COVID-19, children. The search included all types of articles written in English between January 1, 2019 until August 15, 2020.

RESULTS

The search identified 266 relevant articles. Children were mainly within family clusters of cases and have relatively milder clinical presentation compared with adults; children were reported to have better outcomes with a significantly lower mortality rate. Cough and fever were the most common symptoms while pneumonia was the cardinal respiratory manifestation of infected children. Laboratory results and thoracic imaging give varying results.

CONCLUSIONS

Children were mainly family cluster cases and usually presented with a mild infection, although cases presented with the multisystem inflammatory syndrome are becoming more apparent. Studies determining why the manifestations of SARS-CoV-2 infection are so variable may help to gain a better understanding of the disease and accelerate the development of vaccines and therapies.

Authors+Show Affiliations

Medical School, Democritus University of Thrace, Alexandroupolis, Greece.Medical School, Democritus University of Thrace, Alexandroupolis, Greece. Department of Pediatrics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.Departments of Pediatrics and Pediatric Respiratory Medicine, Royal Brompton Harefield NHS Foundation Trust and Imperial College, London, UK.Medical School, Democritus University of Thrace, Alexandroupolis, Greece. Department of Pediatrics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32965785

Citation

Perikleous, Evanthia, et al. "Coronavirus Global Pandemic: an Overview of Current Findings Among Pediatric Patients." Pediatric Pulmonology, vol. 55, no. 12, 2020, pp. 3252-3267.
Perikleous E, Tsalkidis A, Bush A, et al. Coronavirus global pandemic: An overview of current findings among pediatric patients. Pediatr Pulmonol. 2020;55(12):3252-3267.
Perikleous, E., Tsalkidis, A., Bush, A., & Paraskakis, E. (2020). Coronavirus global pandemic: An overview of current findings among pediatric patients. Pediatric Pulmonology, 55(12), 3252-3267. https://doi.org/10.1002/ppul.25087
Perikleous E, et al. Coronavirus Global Pandemic: an Overview of Current Findings Among Pediatric Patients. Pediatr Pulmonol. 2020;55(12):3252-3267. PubMed PMID: 32965785.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coronavirus global pandemic: An overview of current findings among pediatric patients. AU - Perikleous,Evanthia, AU - Tsalkidis,Aggelos, AU - Bush,Andrew, AU - Paraskakis,Emmanouil, Y1 - 2020/10/07/ PY - 2020/05/22/received PY - 2020/09/15/revised PY - 2020/09/17/accepted PY - 2020/9/24/pubmed PY - 2020/11/27/medline PY - 2020/9/23/entrez KW - COVID-19 KW - SARS-CoV-2 KW - children KW - coronavirus SP - 3252 EP - 3267 JF - Pediatric pulmonology JO - Pediatr Pulmonol VL - 55 IS - 12 N2 - BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic has been emerged as a cardinal public health problem. Children have their own specific clinical features; notably, they seem to be escaping the severe respiratory adverse effects. The international scientific community is rapidly carrying out studies, driving to the need to reassess knowledge of the disease and therapeutic strategies. AIM: To assess the characteristics of COVID-19 infected children worldwide of all ages, from neonates to children and adolescents, and how they differ from their adult counterparts. SEARCH STRATEGY: An electronic search in PubMed was conducted, using combinations of the following keywords: coronavirus, SARS-CoV-2, COVID-19, children. The search included all types of articles written in English between January 1, 2019 until August 15, 2020. RESULTS: The search identified 266 relevant articles. Children were mainly within family clusters of cases and have relatively milder clinical presentation compared with adults; children were reported to have better outcomes with a significantly lower mortality rate. Cough and fever were the most common symptoms while pneumonia was the cardinal respiratory manifestation of infected children. Laboratory results and thoracic imaging give varying results. CONCLUSIONS: Children were mainly family cluster cases and usually presented with a mild infection, although cases presented with the multisystem inflammatory syndrome are becoming more apparent. Studies determining why the manifestations of SARS-CoV-2 infection are so variable may help to gain a better understanding of the disease and accelerate the development of vaccines and therapies. SN - 1099-0496 UR - https://www.unboundmedicine.com/medline/citation/32965785/Coronavirus_global_pandemic:_An_overview_of_current_findings_among_pediatric_patients_ L2 - https://doi.org/10.1002/ppul.25087 DB - PRIME DP - Unbound Medicine ER -