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Safety and Efficacy of Different Therapeutic Interventions on Prevention and Treatment of COVID-19.
J Nepal Health Res Counc. 2020 Sep 07; 18(2):151-158.JN

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), a respiratory illness. COVID-19 has now become a global public health crisis causing alarming numbers of morbidity and mortality. Ever since the COVID-19 pandemic started scientists, researchers, universities, companies, and institutions all around the world have been endeavoring to discover a potential treatment for COVID-19. Numerous studies and clinical trials on vaccines and drugs for the prevention and treatment of COVID-19 are underway across the world. However, the uncertainty around the efficacy and safety of various treatment regimens have become one of the biggest challenges in the battle against the SARS-CoV-2. This paper is a narrative review of articles regarding the various treatments and vaccines being tested for the SARS-CoV-2, available in the PubMed database along with Google Scholar. There are ongoing clinical trials on potential drugs such as remdesivir, favipiravir, lopinavir/ritonavir, chloroquine, and hydroxychloroquine, corticosteroids tocilizumab, azithromycin, anakinra, etc. and other therapeutic modalities like convalescent plasma therapy. Likewise, vaccines against SARS-CoV-2 are being developed and tested, including mRNA, non-replicating viral vector, DNA, protein subunit candidate vaccines, etc. Although some early-stage clinical trials and studies on these drugs and vaccines have shown positive results, definitive and conclusive results are yet to be obtained. Keywords: COVID-19; antiviral drugs; COVID-19 treatment; COVID-19 vaccine; SARS-CoV-2.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

Nepal Health Research Council, Ramshah Path, Kathmandu, Nepal.

MeSH

Antiviral AgentsBetacoronavirusCOVID-19COVID-19 VaccinesClinical Trials as TopicCoronavirus InfectionsHumansPandemicsPneumonia, ViralSARS-CoV-2Viral VaccinesCOVID-19 Drug Treatment

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

32969369

Citation

Gyanwali, Pradip, et al. "Safety and Efficacy of Different Therapeutic Interventions On Prevention and Treatment of COVID-19." Journal of Nepal Health Research Council, vol. 18, no. 2, 2020, pp. 151-158.

Gyanwali P, Sharma S, Pant S, et al. Safety and Efficacy of Different Therapeutic Interventions on Prevention and Treatment of COVID-19. J Nepal Health Res Counc. 2020;18(2):151-158.

Gyanwali, P., Sharma, S., Pant, S., Koirala, P., Adhikari, K., Koirala, J., & Dhimal, M. (2020). Safety and Efficacy of Different Therapeutic Interventions on Prevention and Treatment of COVID-19. Journal of Nepal Health Research Council, 18(2), 151-158. https://doi.org/10.33314/jnhrc.v18i2.2806

Gyanwali P, et al. Safety and Efficacy of Different Therapeutic Interventions On Prevention and Treatment of COVID-19. J Nepal Health Res Counc. 2020 Sep 7;18(2):151-158. PubMed PMID: 32969369.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Safety and Efficacy of Different Therapeutic Interventions on Prevention and Treatment of COVID-19. AU - Gyanwali,Pradip, AU - Sharma,Sitasma, AU - Pant,Suman, AU - Koirala,Pallavi, AU - Adhikari,Kriti, AU - Koirala,Janak, AU - Dhimal,Meghnath, Y1 - 2020/09/07/ PY - 2020/6/14/received PY - 2020/9/7/accepted PY - 2020/9/24/entrez PY - 2020/9/25/pubmed PY - 2020/10/2/medline SP - 151 EP - 158 JF - Journal of Nepal Health Research Council JO - J Nepal Health Res Counc VL - 18 IS - 2 N2 - Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the strain of coronavirus that causes coronavirus disease 2019 (COVID-19), a respiratory illness. COVID-19 has now become a global public health crisis causing alarming numbers of morbidity and mortality. Ever since the COVID-19 pandemic started scientists, researchers, universities, companies, and institutions all around the world have been endeavoring to discover a potential treatment for COVID-19. Numerous studies and clinical trials on vaccines and drugs for the prevention and treatment of COVID-19 are underway across the world. However, the uncertainty around the efficacy and safety of various treatment regimens have become one of the biggest challenges in the battle against the SARS-CoV-2. This paper is a narrative review of articles regarding the various treatments and vaccines being tested for the SARS-CoV-2, available in the PubMed database along with Google Scholar. There are ongoing clinical trials on potential drugs such as remdesivir, favipiravir, lopinavir/ritonavir, chloroquine, and hydroxychloroquine, corticosteroids tocilizumab, azithromycin, anakinra, etc. and other therapeutic modalities like convalescent plasma therapy. Likewise, vaccines against SARS-CoV-2 are being developed and tested, including mRNA, non-replicating viral vector, DNA, protein subunit candidate vaccines, etc. Although some early-stage clinical trials and studies on these drugs and vaccines have shown positive results, definitive and conclusive results are yet to be obtained. Keywords: COVID-19; antiviral drugs; COVID-19 treatment; COVID-19 vaccine; SARS-CoV-2. SN - 1999-6217 UR - https://www.unboundmedicine.com/medline/citation/32969369/Safety_and_Efficacy_of_Different_Therapeutic_Interventions_on_Prevention_and_Treatment_of_COVID_19_ DB - PRIME DP - Unbound Medicine ER -