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Continuous-plus-on-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. Postoperative epidural infusion of buprenorphine.
Arzneimittelforschung. 1987 Mar; 37(3):361-3.A

Abstract

In a randomized, double-blind study, buprenorphine was compared with morphine in the treatment of pain after major abdominal operations by means of continuous-plus-on-demand epidural infusion for constant analgesia. The patients received bolus epidural injections of 0.15 mg buprenorphine or 2 mg morphine-HCl prior to an on-demand epidural infusion of 0.03% buprenorphine or 0.25% morphine HCl at a basal rate of 0.06 ml/h. Over 50 h, mean buprenorphine consumption was 0.85 +/- 0.08 mg, and mean morphine consumption was 6.4 +/- 0.5 mg. Under the treatment, no discomfort or side-effects necessitating treatment occurred. We conclude that buprenorphine is a useful substitute for morphine in the treatment of pain after major abdominal operations by continuous-plus-on-demand epidural infusion, and that the relative analgesic potency ratio of epidural buprenorphine is 8.

Authors

Chrubasik J
No affiliation info available
Vogel W
No affiliation info available
Trötschler H
No affiliation info available
Farthmann EH
No affiliation info available

MeSH

AdolescentAdultAgedAged, 80 and overBuprenorphineClinical Trials as TopicDouble-Blind MethodEpidural SpaceFemaleHumansInjectionsMaleMiddle AgedMorphinePain, PostoperativeRandom Allocation

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3297075

Citation

Chrubasik, J, et al. "Continuous-plus-on-demand Epidural Infusion of Buprenorphine Versus Morphine in Postoperative Treatment of Pain. Postoperative Epidural Infusion of Buprenorphine." Arzneimittel-Forschung, vol. 37, no. 3, 1987, pp. 361-3.
Chrubasik J, Vogel W, Trötschler H, et al. Continuous-plus-on-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. Postoperative epidural infusion of buprenorphine. Arzneimittelforschung. 1987;37(3):361-3.
Chrubasik, J., Vogel, W., Trötschler, H., & Farthmann, E. H. (1987). Continuous-plus-on-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. Postoperative epidural infusion of buprenorphine. Arzneimittel-Forschung, 37(3), 361-3.
Chrubasik J, et al. Continuous-plus-on-demand Epidural Infusion of Buprenorphine Versus Morphine in Postoperative Treatment of Pain. Postoperative Epidural Infusion of Buprenorphine. Arzneimittelforschung. 1987;37(3):361-3. PubMed PMID: 3297075.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continuous-plus-on-demand epidural infusion of buprenorphine versus morphine in postoperative treatment of pain. Postoperative epidural infusion of buprenorphine. AU - Chrubasik,J, AU - Vogel,W, AU - Trötschler,H, AU - Farthmann,E H, PY - 1987/3/1/pubmed PY - 1987/3/1/medline PY - 1987/3/1/entrez SP - 361 EP - 3 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 37 IS - 3 N2 - In a randomized, double-blind study, buprenorphine was compared with morphine in the treatment of pain after major abdominal operations by means of continuous-plus-on-demand epidural infusion for constant analgesia. The patients received bolus epidural injections of 0.15 mg buprenorphine or 2 mg morphine-HCl prior to an on-demand epidural infusion of 0.03% buprenorphine or 0.25% morphine HCl at a basal rate of 0.06 ml/h. Over 50 h, mean buprenorphine consumption was 0.85 +/- 0.08 mg, and mean morphine consumption was 6.4 +/- 0.5 mg. Under the treatment, no discomfort or side-effects necessitating treatment occurred. We conclude that buprenorphine is a useful substitute for morphine in the treatment of pain after major abdominal operations by continuous-plus-on-demand epidural infusion, and that the relative analgesic potency ratio of epidural buprenorphine is 8. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3297075/Continuous_plus_on_demand_epidural_infusion_of_buprenorphine_versus_morphine_in_postoperative_treatment_of_pain__Postoperative_epidural_infusion_of_buprenorphine_ DB - PRIME DP - Unbound Medicine ER -