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Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer's and Parkinson's Disease: Insight into the Role of Nrf-2 and A2AR Signaling.
Antioxidants (Basel). 2020 Sep 22; 9(9)A

Abstract

This paper reviews the results of studies conducted on the role of caffeine in the management of different neurological disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD). To highlight the potential role of caffeine in managing different neurodegenerative diseases, we identified studies by searching PubMed, Web of Science, and Google Scholar by scrutinizing the lists of pertinent publications. According to the collected overall findings, caffeine may reduce the elevated oxidative stress; inhibit the activation of adenosine A2A, thereby regulating the accumulation of Aβ; reduce the hyperphosphorylation of tau; and reduce the accumulation of misfolded proteins, such as α-synuclein, in Alzheimer's and Parkinson's diseases. The studies have suggested that caffeine has promising protective effects against different neurodegenerative diseases and that these effects may be used to tackle the neurological diseases and/or their consequences. Here, we review the ongoing research on the role of caffeine in the management of different neurodegenerative disorders, focusing on AD and PD. The current findings suggest that caffeine produces potent antioxidant, inflammatory, and anti-apoptotic effects against different models of neurodegenerative disease, including AD, PD, and other neurodegenerative disorders. Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of α-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases.

Authors+Show Affiliations

Division of Life Science and Applied Life Science (BK21 plus), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.Paul O'Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow 0747 657 5394, UK.Division of Life Science and Applied Life Science (BK21 plus), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.Division of Life Science and Applied Life Science (BK21 plus), College of Natural Sciences, Gyeongsang National University, Jinju 52828, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32971922

Citation

Ikram, Muhammad, et al. "Antioxidant and Neuroprotective Effects of Caffeine Against Alzheimer's and Parkinson's Disease: Insight Into the Role of Nrf-2 and A2AR Signaling." Antioxidants (Basel, Switzerland), vol. 9, no. 9, 2020.
Ikram M, Park TJ, Ali T, et al. Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer's and Parkinson's Disease: Insight into the Role of Nrf-2 and A2AR Signaling. Antioxidants (Basel). 2020;9(9).
Ikram, M., Park, T. J., Ali, T., & Kim, M. O. (2020). Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer's and Parkinson's Disease: Insight into the Role of Nrf-2 and A2AR Signaling. Antioxidants (Basel, Switzerland), 9(9). https://doi.org/10.3390/antiox9090902
Ikram M, et al. Antioxidant and Neuroprotective Effects of Caffeine Against Alzheimer's and Parkinson's Disease: Insight Into the Role of Nrf-2 and A2AR Signaling. Antioxidants (Basel). 2020 Sep 22;9(9) PubMed PMID: 32971922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and Neuroprotective Effects of Caffeine against Alzheimer's and Parkinson's Disease: Insight into the Role of Nrf-2 and A2AR Signaling. AU - Ikram,Muhammad, AU - Park,Tae Ju, AU - Ali,Tahir, AU - Kim,Myeong Ok, Y1 - 2020/09/22/ PY - 2020/09/01/received PY - 2020/09/20/revised PY - 2020/09/21/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/9/26/medline KW - Alzheimer’s disease KW - Parkinson’s disease KW - antioxidant effects KW - caffeine KW - neurodegeneration KW - neuroprotective effects JF - Antioxidants (Basel, Switzerland) JO - Antioxidants (Basel) VL - 9 IS - 9 N2 - This paper reviews the results of studies conducted on the role of caffeine in the management of different neurological disorders, such as Parkinson's disease (PD) and Alzheimer's disease (AD). To highlight the potential role of caffeine in managing different neurodegenerative diseases, we identified studies by searching PubMed, Web of Science, and Google Scholar by scrutinizing the lists of pertinent publications. According to the collected overall findings, caffeine may reduce the elevated oxidative stress; inhibit the activation of adenosine A2A, thereby regulating the accumulation of Aβ; reduce the hyperphosphorylation of tau; and reduce the accumulation of misfolded proteins, such as α-synuclein, in Alzheimer's and Parkinson's diseases. The studies have suggested that caffeine has promising protective effects against different neurodegenerative diseases and that these effects may be used to tackle the neurological diseases and/or their consequences. Here, we review the ongoing research on the role of caffeine in the management of different neurodegenerative disorders, focusing on AD and PD. The current findings suggest that caffeine produces potent antioxidant, inflammatory, and anti-apoptotic effects against different models of neurodegenerative disease, including AD, PD, and other neurodegenerative disorders. Caffeine has shown strong antagonistic effects against the adenosine A2A receptor, which is a microglial receptor, and strong agonistic effects against nuclear-related factor-2 (Nrf-2), thereby regulating the cellular homeostasis at the brain by reducing oxidative stress, neuroinflammation, regulating the accumulation of α-synuclein in PD and tau hyperphosphorylation, amyloidogenesis, and synaptic deficits in AD, which are the cardinal features of these neurodegenerative diseases. SN - 2076-3921 UR - https://www.unboundmedicine.com/medline/citation/32971922/Antioxidant_and_Neuroprotective_Effects_of_Caffeine_against_Alzheimer's_and_Parkinson's_Disease:_Insight_into_the_Role_of_Nrf_2_and_A2AR_Signaling_ DB - PRIME DP - Unbound Medicine ER -
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