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Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19.
Korean J Intern Med. 2021 01; 36(1):11-14.KJ

Abstract

Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regarding the medical measures and policies. We evaluated the dynamics of viral load and anti-SARS-CoV-2 antibodies in four patients with positive RT-PCR results after recovery. In all patients, the highest levels of immunoglobulin G (IgG) and IgM antibodies were reached after about a month of the onset of the initial symptoms. Then, the IgG titers plateaued, and the IgM titers decreased, regardless of RT-PCR results. The IgG and IgM levels did not increase after the post-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to the detection of RNA particles rather than reinfection in individuals who have recovered from COVID-19.

Authors+Show Affiliations

Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Chosun University Hospital, Gwangju, Korea.Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Korea.Division of Infectious Diseases, Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea.Department of Infectious Diseases, Seongnam Citizens Medical Center, Seongnam, Korea.Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Laboratory Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32972123

Citation

Song, Kyoung-Ho, et al. "Dynamics of Viral Load and anti-SARS-CoV-2 Antibodies in Patients With Positive RT-PCR Results After Recovery From COVID-19." The Korean Journal of Internal Medicine, vol. 36, no. 1, 2021, pp. 11-14.
Song KH, Kim DM, Lee H, et al. Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19. Korean J Intern Med. 2021;36(1):11-14.
Song, K. H., Kim, D. M., Lee, H., Ham, S. Y., Oh, S. M., Jeong, H., Jung, J., Kang, C. K., Park, J. Y., Kang, Y. M., Kim, J. Y., Park, J. S., Park, K. U., Kim, E. S., & Kim, H. B. (2021). Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19. The Korean Journal of Internal Medicine, 36(1), 11-14. https://doi.org/10.3904/kjim.2020.325
Song KH, et al. Dynamics of Viral Load and anti-SARS-CoV-2 Antibodies in Patients With Positive RT-PCR Results After Recovery From COVID-19. Korean J Intern Med. 2021;36(1):11-14. PubMed PMID: 32972123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dynamics of viral load and anti-SARS-CoV-2 antibodies in patients with positive RT-PCR results after recovery from COVID-19. AU - Song,Kyoung-Ho, AU - Kim,Dong-Min, AU - Lee,Hyunju, AU - Ham,Sin Young, AU - Oh,Sang-Min, AU - Jeong,Hyeonju, AU - Jung,Jongtak, AU - Kang,Chang Kyung, AU - Park,Ji Young, AU - Kang,Yu Min, AU - Kim,Ji-Yeon, AU - Park,Jeong Su, AU - Park,Kyoung Un, AU - Kim,Eu Suk, AU - Kim,Hong Bin, Y1 - 2020/11/25/ PY - 2020/06/29/received PY - 2020/09/04/accepted PY - 2020/9/26/pubmed PY - 2021/1/28/medline PY - 2020/9/25/entrez KW - COVID-19 KW - Reinfection KW - Severe acute respiratory syndrome coronavirus 2 SP - 11 EP - 14 JF - The Korean journal of internal medicine JO - Korean J Intern Med VL - 36 IS - 1 N2 - Recently, the number of patients with coronavirus disease 2019 (COVID-19) who have tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), via the reverse transcription polymerase chain reaction (RT-PCR) test, after recovery has increased; this has caused a dilemma regarding the medical measures and policies. We evaluated the dynamics of viral load and anti-SARS-CoV-2 antibodies in four patients with positive RT-PCR results after recovery. In all patients, the highest levels of immunoglobulin G (IgG) and IgM antibodies were reached after about a month of the onset of the initial symptoms. Then, the IgG titers plateaued, and the IgM titers decreased, regardless of RT-PCR results. The IgG and IgM levels did not increase after the post-negative positive RT-PCR results in any of the patients. Our results reinforced that the post-negative positive RT-PCR results may be due to the detection of RNA particles rather than reinfection in individuals who have recovered from COVID-19. SN - 2005-6648 UR - https://www.unboundmedicine.com/medline/citation/32972123/Dynamics_of_viral_load_and_anti_SARS_CoV_2_antibodies_in_patients_with_positive_RT_PCR_results_after_recovery_from_COVID_19_ L2 - https://dx.doi.org/10.3904/kjim.2020.325 DB - PRIME DP - Unbound Medicine ER -