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Point of view: Should COVID-19 patients be supplemented with vitamin D?
Maturitas. 2020 Oct; 140:24-26.M

Abstract

Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19.

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ncbi.nlm.nih.gov
linkinghub.elsevier.com
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Authors+Show Affiliations

Annweiler C
Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France; UPRES EA 4638, University of Angers, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada. Electronic address: Cedric.Annweiler@chu-angers.fr.
Cao Z
State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Hubei Province Engineering and Technology Research, Center for Fluorinated Pharmaceuticals, Wuhan University, Wuhan, 430072, China. Electronic address: zjcao@whu.edu.cn.
Sabatier JM
Aix-Marseille University, Institute of NeuroPhysiopathology, UMR 7051, 27, Bd Jean Moulin, 13385, Marseille Cedex, France.

MeSH

BetacoronavirusCOVID-19CausalityCoronavirus InfectionsDietary SupplementsHumansPandemicsPneumonia, ViralPrognosisSARS-CoV-2Vitamin DVitamin D DeficiencyVitamins

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32972631

Citation

Annweiler, Cédric, et al. "Point of View: Should COVID-19 Patients Be Supplemented With Vitamin D?" Maturitas, vol. 140, 2020, pp. 24-26.
Annweiler C, Cao Z, Sabatier JM. Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas. 2020;140:24-26.
Annweiler, C., Cao, Z., & Sabatier, J. M. (2020). Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas, 140, 24-26. https://doi.org/10.1016/j.maturitas.2020.06.003
Annweiler C, Cao Z, Sabatier JM. Point of View: Should COVID-19 Patients Be Supplemented With Vitamin D. Maturitas. 2020;140:24-26. PubMed PMID: 32972631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Point of view: Should COVID-19 patients be supplemented with vitamin D? AU - Annweiler,Cédric, AU - Cao,Zhijian, AU - Sabatier,Jean-Marc, Y1 - 2020/06/08/ PY - 2020/05/14/received PY - 2020/06/04/revised PY - 2020/06/05/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/2/medline KW - Biomarker KW - COVID-19 KW - Causality KW - SARS-CoV-2 KW - Treatment KW - Vitamin D SP - 24 EP - 26 JF - Maturitas JO - Maturitas VL - 140 N2 - Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/32972631/Point_of_view:_Should_COVID_19_patients_be_supplemented_with_vitamin_D L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(20)30292-9 DB - PRIME DP - Unbound Medicine ER -