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Point of view: Should COVID-19 patients be supplemented with vitamin D?
Maturitas. 2020 Oct; 140:24-26.M

Abstract

Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19.

Authors+Show Affiliations

Department of Geriatric Medicine and Memory Clinic, Research Center on Autonomy and Longevity, University Hospital, Angers, France; UPRES EA 4638, University of Angers, Angers, France; Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada. Electronic address: Cedric.Annweiler@chu-angers.fr.State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, 430072, China; Hubei Province Engineering and Technology Research, Center for Fluorinated Pharmaceuticals, Wuhan University, Wuhan, 430072, China. Electronic address: zjcao@whu.edu.cn.Aix-Marseille University, Institute of NeuroPhysiopathology, UMR 7051, 27, Bd Jean Moulin, 13385, Marseille Cedex, France.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32972631

Citation

Annweiler, Cédric, et al. "Point of View: Should COVID-19 Patients Be Supplemented With Vitamin D?" Maturitas, vol. 140, 2020, pp. 24-26.
Annweiler C, Cao Z, Sabatier JM. Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas. 2020;140:24-26.
Annweiler, C., Cao, Z., & Sabatier, J. M. (2020). Point of view: Should COVID-19 patients be supplemented with vitamin D? Maturitas, 140, 24-26. https://doi.org/10.1016/j.maturitas.2020.06.003
Annweiler C, Cao Z, Sabatier JM. Point of View: Should COVID-19 Patients Be Supplemented With Vitamin D. Maturitas. 2020;140:24-26. PubMed PMID: 32972631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Point of view: Should COVID-19 patients be supplemented with vitamin D? AU - Annweiler,Cédric, AU - Cao,Zhijian, AU - Sabatier,Jean-Marc, Y1 - 2020/06/08/ PY - 2020/05/14/received PY - 2020/06/04/revised PY - 2020/06/05/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/2/medline KW - Biomarker KW - COVID-19 KW - Causality KW - SARS-CoV-2 KW - Treatment KW - Vitamin D SP - 24 EP - 26 JF - Maturitas JO - Maturitas VL - 140 N2 - Using Hill's methodology for exploring causality, we aimed to determine in early May 2020 whether evidence supports vitamin D as a biological determinant of COVID-19 outcomes. Vitamin D is a secosteroid hormone theoretically able to reduce COVID-19 risk through regulation of (i) the renin-angiotensin system, (ii) cellular innate and adaptive immunity, and (iii) physical barriers. Inverse associations were found between 25-hydroxyvitamin D concentrations and COVID-19 incidence and mortality. Randomized controlled trials testing vitamin D supplementation in the treatment of COVID-19 are in progress. Positive results in such studies would encourage the use of vitamin D supplements as an adjuvant treatment in COVID-19. SN - 1873-4111 UR - https://www.unboundmedicine.com/medline/citation/32972631/Point_of_view:_Should_COVID_19_patients_be_supplemented_with_vitamin_D L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(20)30292-9 DB - PRIME DP - Unbound Medicine ER -