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The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development.
Front Immunol. 2020; 11:1880.FI

Abstract

Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome infecting animals and humans. Coronaviruses have been described more than 70 years ago and contain many species. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are lethal species caused by human coronaviruses (HCoVs). Currently, a novel strain of HCoVs, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19). SARS-CoV-2 was first identified in December 2019 in Wuhan, the capital city of the Hubei province of China, and has since spread worldwide causing an outbreak in more than 200 countries. The SARS-CoV-2 outbreak was declared a pandemic on March 11th, 2020 and a public health emergency of international concern (PHEIC) in late January 2020 by the World Health Organization (WHO). SARS-CoV-2 infects the respiratory tract causing flu-like symptoms and, in some, may cause severe illness like pneumonia and multi-organ failure leading to death. Today, Covid-19 cases almost reaching 9 million, with more than 450 thousand deaths. There is an urgent demand for developing a vaccine since no effective therapies or vaccines have been approved to this day to prevent or minimize the spread of the infection. In this review, we summarized the furthest vaccines in the clinical pipeline.

Authors+Show Affiliations

Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States. Department of Medical Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States. Department of Medical Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States. Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, United States.Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States.Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States. Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, United States.Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States. Department of Medical Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, United States.Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, United States. Division of Infectious Diseases and HIV Medicine, Department of Medicine, Drexel University College of Medicine, Philadelphia, PA, United States.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

32973779

Citation

Alturki, Sana O., et al. "The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development." Frontiers in Immunology, vol. 11, 2020, p. 1880.
Alturki SO, Alturki SO, Connors J, et al. The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development. Front Immunol. 2020;11:1880.
Alturki, S. O., Alturki, S. O., Connors, J., Cusimano, G., Kutzler, M. A., Izmirly, A. M., & Haddad, E. K. (2020). The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development. Frontiers in Immunology, 11, 1880. https://doi.org/10.3389/fimmu.2020.01880
Alturki SO, et al. The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development. Front Immunol. 2020;11:1880. PubMed PMID: 32973779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The 2020 Pandemic: Current SARS-CoV-2 Vaccine Development. AU - Alturki,Sana O, AU - Alturki,Sawsan O, AU - Connors,Jennifer, AU - Cusimano,Gina, AU - Kutzler,Michele A, AU - Izmirly,Abdullah M, AU - Haddad,Elias K, Y1 - 2020/08/19/ PY - 2020/05/14/received PY - 2020/07/13/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/21/medline KW - Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) KW - antibody dependent enhancement (ADE) KW - clinical trial KW - coronavirus disease 2019 (Covid-19) KW - pandemic KW - receptor binding domain (RBD) KW - spike (S) protein SP - 1880 EP - 1880 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - Coronaviruses are enveloped viruses with a positive-sense single-stranded RNA genome infecting animals and humans. Coronaviruses have been described more than 70 years ago and contain many species. Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS) are lethal species caused by human coronaviruses (HCoVs). Currently, a novel strain of HCoVs, named Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (Covid-19). SARS-CoV-2 was first identified in December 2019 in Wuhan, the capital city of the Hubei province of China, and has since spread worldwide causing an outbreak in more than 200 countries. The SARS-CoV-2 outbreak was declared a pandemic on March 11th, 2020 and a public health emergency of international concern (PHEIC) in late January 2020 by the World Health Organization (WHO). SARS-CoV-2 infects the respiratory tract causing flu-like symptoms and, in some, may cause severe illness like pneumonia and multi-organ failure leading to death. Today, Covid-19 cases almost reaching 9 million, with more than 450 thousand deaths. There is an urgent demand for developing a vaccine since no effective therapies or vaccines have been approved to this day to prevent or minimize the spread of the infection. In this review, we summarized the furthest vaccines in the clinical pipeline. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/32973779/The_2020_Pandemic:_Current_SARS_CoV_2_Vaccine_Development_ L2 - https://doi.org/10.3389/fimmu.2020.01880 DB - PRIME DP - Unbound Medicine ER -