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Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections.
Front Immunol. 2020; 11:1979.FI

Abstract

The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in <3 months, infecting millions of people, and causing countries to shut down public life and businesses. Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. Infection with SARS-CoV-2 can lead to Coronavirus disease 2019 (COVID-19). COVID-19 is respiratory disease that can result in a cytokine storm with stark differences in morbidity and mortality between younger and older patient populations. Details regarding mechanisms of viral entry via the respiratory system and immune system correlates of protection or pathogenesis have not been fully elucidated. Here, we provide an overview of the innate immune responses in the lung to the coronaviruses MERS-CoV, SARS-CoV, and SARS-CoV-2. This review provides insight into key innate immune mechanisms that will aid in the development of therapeutics and preventive vaccines for SARS-CoV-2 infection.

Authors+Show Affiliations

Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States. Department of Zoonoses, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States.Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, United States.The James Comprehensive Cancer Center, Pelotonia Institute for Immuno-Oncology, The Ohio State University, Columbus, OH, United States.Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, United States.Marker Therapeutics Inc., Houston, TX, United States.Department of Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, OH, United States. Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus, OH, United States. Infectious Diseases Institute, The Ohio State University, Columbus, OH, United States.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32973803

Citation

Ahmed-Hassan, Hanaa, et al. "Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections." Frontiers in Immunology, vol. 11, 2020, p. 1979.
Ahmed-Hassan H, Sisson B, Shukla RK, et al. Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections. Front Immunol. 2020;11:1979.
Ahmed-Hassan, H., Sisson, B., Shukla, R. K., Wijewantha, Y., Funderburg, N. T., Li, Z., Hayes, D., Demberg, T., & Liyanage, N. P. M. (2020). Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections. Frontiers in Immunology, 11, 1979. https://doi.org/10.3389/fimmu.2020.01979
Ahmed-Hassan H, et al. Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections. Front Immunol. 2020;11:1979. PubMed PMID: 32973803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Innate Immune Responses to Highly Pathogenic Coronaviruses and Other Significant Respiratory Viral Infections. AU - Ahmed-Hassan,Hanaa, AU - Sisson,Brianna, AU - Shukla,Rajni Kant, AU - Wijewantha,Yasasvi, AU - Funderburg,Nicholas T, AU - Li,Zihai, AU - Hayes,Don,Jr AU - Demberg,Thorsten, AU - Liyanage,Namal P M, Y1 - 2020/08/18/ PY - 2020/05/04/received PY - 2020/07/22/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/21/medline KW - COVID-19 KW - Coronavirus (2019-nCoV) outbreak KW - Coronavirus (CoV) KW - SARS-CoV-2 KW - innate immune responses SP - 1979 EP - 1979 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - The new pandemic virus SARS-CoV-2 emerged in China and spread around the world in <3 months, infecting millions of people, and causing countries to shut down public life and businesses. Nearly all nations were unprepared for this pandemic with healthcare systems stretched to their limits due to the lack of an effective vaccine and treatment. Infection with SARS-CoV-2 can lead to Coronavirus disease 2019 (COVID-19). COVID-19 is respiratory disease that can result in a cytokine storm with stark differences in morbidity and mortality between younger and older patient populations. Details regarding mechanisms of viral entry via the respiratory system and immune system correlates of protection or pathogenesis have not been fully elucidated. Here, we provide an overview of the innate immune responses in the lung to the coronaviruses MERS-CoV, SARS-CoV, and SARS-CoV-2. This review provides insight into key innate immune mechanisms that will aid in the development of therapeutics and preventive vaccines for SARS-CoV-2 infection. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/32973803/Innate_Immune_Responses_to_Highly_Pathogenic_Coronaviruses_and_Other_Significant_Respiratory_Viral_Infections_ L2 - https://doi.org/10.3389/fimmu.2020.01979 DB - PRIME DP - Unbound Medicine ER -