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Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2).

Abstract

SARS CoV appeared in 2003 in China, transmitted from bats to humans via eating infected animals. It affected 8,096 humans with a death rate of 11% affecting 21 countries. The receptor binding domain (RBD) in S protein of this virus gets attached with the ACE2 receptors present on human cells. MERS CoV was first reported in 2012 in Middle East, originated from bat and transmitted to humans through camels. MERS CoV has a fatality rate of 35% and last case reported was in 2017 making a total of 1,879 cases worldwide. DPP4 expressed on human cells is the main attaching site for RBD in S protein of MERS CoV. Folding of RBD plays a crucial role in its pathogenesis. Virus causing COVID-19 was named as SARS CoV-2 due its homology with SARS CoV that emerged in 2003. It has become a pandemic affecting nearly 200 countries in just 3 months' time with a death rate of 2-3% currently. The new virus is fast spreading, but it utilizes the same RBD and ACE2 receptors along with furin present in human cells. The lessons learned from the SARS and MERS epidemics are the best social weapons to face and fight against this novel global threat.

Authors+Show Affiliations

Department of Biotechnology, Fatima Jinnah Women University, Rawalpindi, Pakistan.Department of Zoology, University of Gujrat, Gujrat, Pakistan.Oil and Gas Development Company Limited, Islamabad, Pakistan.Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China.Department of Epidemiology and Biostatistics, School of Health Sciences, Wuhan University, Wuhan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

32974224

Citation

Masood, Nosheen, et al. "Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2)." Frontiers in Cellular and Infection Microbiology, vol. 10, 2020, p. 499.
Masood N, Malik SS, Raja MN, et al. Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2). Front Cell Infect Microbiol. 2020;10:499.
Masood, N., Malik, S. S., Raja, M. N., Mubarik, S., & Yu, C. (2020). Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2). Frontiers in Cellular and Infection Microbiology, 10, 499. https://doi.org/10.3389/fcimb.2020.00499
Masood N, et al. Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2). Front Cell Infect Microbiol. 2020;10:499. PubMed PMID: 32974224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unraveling the Epidemiology, Geographical Distribution, and Genomic Evolution of Potentially Lethal Coronaviruses (SARS, MERS, and SARS CoV-2). AU - Masood,Nosheen, AU - Malik,Saima Shakil, AU - Raja,Muhammad Naqqi, AU - Mubarik,Sumaira, AU - Yu,Chuanhua, Y1 - 2020/08/27/ PY - 2020/03/27/received PY - 2020/08/11/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/6/medline KW - ACE2 KW - COVID-19 KW - DPP4 KW - MERS CoV KW - SARS CoV KW - SARS CoV-2 SP - 499 EP - 499 JF - Frontiers in cellular and infection microbiology JO - Front Cell Infect Microbiol VL - 10 N2 - SARS CoV appeared in 2003 in China, transmitted from bats to humans via eating infected animals. It affected 8,096 humans with a death rate of 11% affecting 21 countries. The receptor binding domain (RBD) in S protein of this virus gets attached with the ACE2 receptors present on human cells. MERS CoV was first reported in 2012 in Middle East, originated from bat and transmitted to humans through camels. MERS CoV has a fatality rate of 35% and last case reported was in 2017 making a total of 1,879 cases worldwide. DPP4 expressed on human cells is the main attaching site for RBD in S protein of MERS CoV. Folding of RBD plays a crucial role in its pathogenesis. Virus causing COVID-19 was named as SARS CoV-2 due its homology with SARS CoV that emerged in 2003. It has become a pandemic affecting nearly 200 countries in just 3 months' time with a death rate of 2-3% currently. The new virus is fast spreading, but it utilizes the same RBD and ACE2 receptors along with furin present in human cells. The lessons learned from the SARS and MERS epidemics are the best social weapons to face and fight against this novel global threat. SN - 2235-2988 UR - https://www.unboundmedicine.com/medline/citation/32974224/Unraveling_the_Epidemiology_Geographical_Distribution_and_Genomic_Evolution_of_Potentially_Lethal_Coronaviruses__SARS_MERS_and_SARS_CoV_2__ L2 - https://doi.org/10.3389/fcimb.2020.00499 DB - PRIME DP - Unbound Medicine ER -