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Characterization of the microbiome in the infant diapered area: Insights from healthy and damaged skin.
Exp Dermatol. 2021 10; 30(10):1409-1417.ED

Abstract

It has been recognized for nearly a century that human beings are inhabited by a remarkably dense and diverse microbial ecosystem, yet we are only just beginning to understand and appreciate the many roles that these microbes play in human health and development. Establishment of the microbiome begins at birth, but many previous studies on infant skin health have focused on Candida species. Little is known on the full microbial composition across different areas and even less is known on how these communities change during disease/inflammatory states. In this clinical study, infants were recruited during periods of diaper dermatitis (DD) and health to characterize the skin microbiome in these two states. Substantial shifts in the skin microbiome were observed across four sites in the diapered area (genitals, intertriginous, buttocks and perianal), as well as during periods of DD. As DD scores increased, there was a shift in relative abundance that demonstrated higher community percentages of faecal coliforms, such as Enterococcus, and lower percentages of Staphylococcus strains. In high-rash samples, the predominant Staphylococcus species is S aureus, potentially implicating S aureus as a DD aetiological agent. This study provides new information related to the microbiome on infant skin in the diapered area and provides insights into the role of the microbiome in the development of DD.

Links

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Authors+Show Affiliations

Teufel A
The Procter and Gamble Company, Cincinnati, OH, USA.
Howard B
The Procter and Gamble Company, Cincinnati, OH, USA.
Hu P
The Procter and Gamble Company, Cincinnati, OH, USA.
Carr AN
The Procter and Gamble Company, Cincinnati, OH, USA.

MeSH

ButtocksDiaper RashDiapers, InfantFemaleHumansInfantInfant CareLongitudinal StudiesMaleMicrobiotaSkin

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

32974911

Clinical Trial Links

Effect Of Using Oxygen On The Diaper Dermatitis In Infants

Citation

Teufel, Amber, et al. "Characterization of the Microbiome in the Infant Diapered Area: Insights From Healthy and Damaged Skin." Experimental Dermatology, vol. 30, no. 10, 2021, pp. 1409-1417.
Teufel A, Howard B, Hu P, et al. Characterization of the microbiome in the infant diapered area: Insights from healthy and damaged skin. Exp Dermatol. 2021;30(10):1409-1417.
Teufel, A., Howard, B., Hu, P., & Carr, A. N. (2021). Characterization of the microbiome in the infant diapered area: Insights from healthy and damaged skin. Experimental Dermatology, 30(10), 1409-1417. https://doi.org/10.1111/exd.14198
Teufel A, et al. Characterization of the Microbiome in the Infant Diapered Area: Insights From Healthy and Damaged Skin. Exp Dermatol. 2021;30(10):1409-1417. PubMed PMID: 32974911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of the microbiome in the infant diapered area: Insights from healthy and damaged skin. AU - Teufel,Amber, AU - Howard,Brian, AU - Hu,Ping, AU - Carr,Andrew N, Y1 - 2020/10/13/ PY - 2020/09/09/revised PY - 2020/04/30/received PY - 2020/09/11/accepted PY - 2020/9/26/pubmed PY - 2022/3/30/medline PY - 2020/9/25/entrez KW - Candida KW - Staphylococcus KW - diaper rash KW - infant KW - microbiota SP - 1409 EP - 1417 JF - Experimental dermatology JO - Exp Dermatol VL - 30 IS - 10 N2 - It has been recognized for nearly a century that human beings are inhabited by a remarkably dense and diverse microbial ecosystem, yet we are only just beginning to understand and appreciate the many roles that these microbes play in human health and development. Establishment of the microbiome begins at birth, but many previous studies on infant skin health have focused on Candida species. Little is known on the full microbial composition across different areas and even less is known on how these communities change during disease/inflammatory states. In this clinical study, infants were recruited during periods of diaper dermatitis (DD) and health to characterize the skin microbiome in these two states. Substantial shifts in the skin microbiome were observed across four sites in the diapered area (genitals, intertriginous, buttocks and perianal), as well as during periods of DD. As DD scores increased, there was a shift in relative abundance that demonstrated higher community percentages of faecal coliforms, such as Enterococcus, and lower percentages of Staphylococcus strains. In high-rash samples, the predominant Staphylococcus species is S aureus, potentially implicating S aureus as a DD aetiological agent. This study provides new information related to the microbiome on infant skin in the diapered area and provides insights into the role of the microbiome in the development of DD. SN - 1600-0625 UR - https://www.unboundmedicine.com/medline/citation/32974911/Characterization_of_the_microbiome_in_the_infant_diapered_area:_Insights_from_healthy_and_damaged_skin_ DB - PRIME DP - Unbound Medicine ER -