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Olfactory and gustatory dysfunction in COVID-19 patients: A meta-analysis study.
Physiol Rep. 2020 09; 8(18):e14578.PR

Abstract

COVID-19, caused by a novel coronavirus, is a persistent global pandemic. It is crucial to examine existing reports to effectively summarize and characterize its clinical course. We used a large-scale meta-analysis to establish prevalence rates for loss of olfaction and gustation in COVID-19 positive patients. PubMed/Medline, Embase, and Web of Sciences were searched for articles published until April 30, 2020. Furthermore, to avoid missing papers, more searches were carried out in the reference lists of covered studies. Articles that mentioned olfactory and/or gustatory disorder in patients with COVID-19 were included for further analysis. Articles that did not report the aforementioned information were excluded. Duplicated articles, reviews, and meta-analysis were excluded as well. The quality of the references was assessed according to the checklist provided by JBI (Joanna Briggs Institute). We used independent extraction of data by multiple observers. The pooled frequency with 95% confidence intervals (CI) was assessed using random effect model. The main outcome measures reported were the pooled frequency of olfaction and pooled frequency of gustation disorder in patients with COVID-19 calculated using a random effect model weighted by the study population. The 15 included studies had 3,739 participants which all had confirmed COVID-19. Olfactory and gustatory disorders were assessed and a total number of 1,354 and 1,729 were reported to have taste or smell impairment, respectively. The estimated rate of taste disorder in patients with COVID-19 was 49.0% [95% confidence interval (CI) 34.0-64.0, I2: 96%] (Figure 2). The estimated rate of olfactory disorder in patients with COVID-19 was 61.0% (95% CI 44.0%-75.0%). Our meta-analysis demonstrated high rates of taste (49.0%) and smell (61.0%) disorders in patients with confirmed COVID-19. Results increase the power of recent reports-loss of olfactory and loss of gustation should now routinely be considered in the setting of COVID-19 infection.

Authors+Show Affiliations

Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Miller School of Medicine, University of Miami, Miami, FL, USA.Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Microbiology, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Otolaryngology, University of Miami Hearing Research Laboratory, Miller School of Medicine, Miami, FL, USA.No affiliation info availableDivision of Pulmonary and Critical Care, University of Miami, Miami, FL, USA.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32975884

Citation

Hajikhani, Bahareh, et al. "Olfactory and Gustatory Dysfunction in COVID-19 Patients: a Meta-analysis Study." Physiological Reports, vol. 8, no. 18, 2020, pp. e14578.
Hajikhani B, Calcagno T, Nasiri MJ, et al. Olfactory and gustatory dysfunction in COVID-19 patients: A meta-analysis study. Physiol Rep. 2020;8(18):e14578.
Hajikhani, B., Calcagno, T., Nasiri, M. J., Jamshidi, P., Dadashi, M., Goudarzi, M., Eshraghi, A. A., & Mirsaeidi, M. (2020). Olfactory and gustatory dysfunction in COVID-19 patients: A meta-analysis study. Physiological Reports, 8(18), e14578. https://doi.org/10.14814/phy2.14578
Hajikhani B, et al. Olfactory and Gustatory Dysfunction in COVID-19 Patients: a Meta-analysis Study. Physiol Rep. 2020;8(18):e14578. PubMed PMID: 32975884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Olfactory and gustatory dysfunction in COVID-19 patients: A meta-analysis study. AU - Hajikhani,Bahareh, AU - Calcagno,Tess, AU - Nasiri,Mohammad Javad, AU - Jamshidi,Parnian, AU - Dadashi,Masoud, AU - Goudarzi,Mehdi, AU - Eshraghi,Adrien A, AU - ,, AU - Mirsaeidi,Mehdi, PY - 2020/06/29/received PY - 2020/08/09/revised PY - 2020/08/11/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/2/medline KW - COVID-19 KW - gustatory KW - olfactory KW - smell KW - taste SP - e14578 EP - e14578 JF - Physiological reports JO - Physiol Rep VL - 8 IS - 18 N2 - COVID-19, caused by a novel coronavirus, is a persistent global pandemic. It is crucial to examine existing reports to effectively summarize and characterize its clinical course. We used a large-scale meta-analysis to establish prevalence rates for loss of olfaction and gustation in COVID-19 positive patients. PubMed/Medline, Embase, and Web of Sciences were searched for articles published until April 30, 2020. Furthermore, to avoid missing papers, more searches were carried out in the reference lists of covered studies. Articles that mentioned olfactory and/or gustatory disorder in patients with COVID-19 were included for further analysis. Articles that did not report the aforementioned information were excluded. Duplicated articles, reviews, and meta-analysis were excluded as well. The quality of the references was assessed according to the checklist provided by JBI (Joanna Briggs Institute). We used independent extraction of data by multiple observers. The pooled frequency with 95% confidence intervals (CI) was assessed using random effect model. The main outcome measures reported were the pooled frequency of olfaction and pooled frequency of gustation disorder in patients with COVID-19 calculated using a random effect model weighted by the study population. The 15 included studies had 3,739 participants which all had confirmed COVID-19. Olfactory and gustatory disorders were assessed and a total number of 1,354 and 1,729 were reported to have taste or smell impairment, respectively. The estimated rate of taste disorder in patients with COVID-19 was 49.0% [95% confidence interval (CI) 34.0-64.0, I2: 96%] (Figure 2). The estimated rate of olfactory disorder in patients with COVID-19 was 61.0% (95% CI 44.0%-75.0%). Our meta-analysis demonstrated high rates of taste (49.0%) and smell (61.0%) disorders in patients with confirmed COVID-19. Results increase the power of recent reports-loss of olfactory and loss of gustation should now routinely be considered in the setting of COVID-19 infection. SN - 2051-817X UR - https://www.unboundmedicine.com/medline/citation/32975884/Olfactory_and_gustatory_dysfunction_in_COVID_19_patients:_A_meta_analysis_study_ L2 - https://doi.org/10.14814/phy2.14578 DB - PRIME DP - Unbound Medicine ER -