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Treatment of Raynaud's phenomenon with captopril.
Drugs Exp Clin Res. 1987; 13(1):37-42.DE

Abstract

The efficacy of captopril in the treatment of Raynaud's phenomenon was observed in an open study in 53 patients with primitive Raynaud's disease and in 18 patients with Raynaud's associated with scleroderma. Each patient was given captopril 25 mg three times a day for three months. The drug significantly decreased the frequency and the severity of ischaemic attacks in patients with Raynaud's disease, but did not affect the attacks in patients with scleroderma. These subjective ratings were supported by the results of digital strain gauge plethysmography during cold challenge. The therapy was discontinued in six patients (one because of an allergic skin reaction and five owing to orthostatic hypotension), but no serious side-effects were noticed.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3297593

Citation

Tosi, S, et al. "Treatment of Raynaud's Phenomenon With Captopril." Drugs Under Experimental and Clinical Research, vol. 13, no. 1, 1987, pp. 37-42.
Tosi S, Marchesoni A, Messina K, et al. Treatment of Raynaud's phenomenon with captopril. Drugs Exp Clin Res. 1987;13(1):37-42.
Tosi, S., Marchesoni, A., Messina, K., Bellintani, C., Sironi, G., & Faravelli, C. (1987). Treatment of Raynaud's phenomenon with captopril. Drugs Under Experimental and Clinical Research, 13(1), 37-42.
Tosi S, et al. Treatment of Raynaud's Phenomenon With Captopril. Drugs Exp Clin Res. 1987;13(1):37-42. PubMed PMID: 3297593.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of Raynaud's phenomenon with captopril. AU - Tosi,S, AU - Marchesoni,A, AU - Messina,K, AU - Bellintani,C, AU - Sironi,G, AU - Faravelli,C, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 37 EP - 42 JF - Drugs under experimental and clinical research JO - Drugs Exp Clin Res VL - 13 IS - 1 N2 - The efficacy of captopril in the treatment of Raynaud's phenomenon was observed in an open study in 53 patients with primitive Raynaud's disease and in 18 patients with Raynaud's associated with scleroderma. Each patient was given captopril 25 mg three times a day for three months. The drug significantly decreased the frequency and the severity of ischaemic attacks in patients with Raynaud's disease, but did not affect the attacks in patients with scleroderma. These subjective ratings were supported by the results of digital strain gauge plethysmography during cold challenge. The therapy was discontinued in six patients (one because of an allergic skin reaction and five owing to orthostatic hypotension), but no serious side-effects were noticed. SN - 0378-6501 UR - https://www.unboundmedicine.com/medline/citation/3297593/Treatment_of_Raynaud's_phenomenon_with_captopril_ L2 - https://medlineplus.gov/raynaudsdisease.html DB - PRIME DP - Unbound Medicine ER -