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The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19.
PLoS One. 2020; 15(9):e0239532.Plos

Abstract

To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease.

Authors+Show Affiliations

Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The Affiliated Infectious Diseases Hospital of Nanchang University, Nanchang, Jiangxi, China.Department of Nosocomial infection, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China.Department of Infectious Disease, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of respiration, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China.Department of Clinical Laboratory, The 908th Hospital of The Joint Logistics Support Force of The Chinese People's Liberation Army, Nanchang, Jiangxi, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32976531

Citation

Sun, Hua-Bao, et al. "The Changes of the Peripheral CD4+ Lymphocytes and Inflammatory Cytokines in Patients With COVID-19." PloS One, vol. 15, no. 9, 2020, pp. e0239532.
Sun HB, Zhang YM, Huang LG, et al. The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19. PLoS One. 2020;15(9):e0239532.
Sun, H. B., Zhang, Y. M., Huang, L. G., Lai, Q. N., Mo, Q., Ye, X. Z., Wang, T., Zhu, Z. Z., Lv, X. L., Luo, Y. J., Gao, S. D., Xu, J. S., Zhu, H. H., Li, T., & Wang, Z. K. (2020). The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19. PloS One, 15(9), e0239532. https://doi.org/10.1371/journal.pone.0239532
Sun HB, et al. The Changes of the Peripheral CD4+ Lymphocytes and Inflammatory Cytokines in Patients With COVID-19. PLoS One. 2020;15(9):e0239532. PubMed PMID: 32976531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The changes of the peripheral CD4+ lymphocytes and inflammatory cytokines in Patients with COVID-19. AU - Sun,Hua-Bao, AU - Zhang,Yi-Ming, AU - Huang,Li-Gui, AU - Lai,Qi-Nan, AU - Mo,Qun, AU - Ye,Xin-Zhou, AU - Wang,Tao, AU - Zhu,Zhong-Zhen, AU - Lv,Xiao-Lin, AU - Luo,Yan-Ji, AU - Gao,Shi-Ding, AU - Xu,Jin-Song, AU - Zhu,Hao-Hao, AU - Li,Ting, AU - Wang,Zhan-Ke, Y1 - 2020/09/25/ PY - 2020/04/26/received PY - 2020/09/09/accepted PY - 2020/9/25/entrez PY - 2020/9/26/pubmed PY - 2020/10/21/medline SP - e0239532 EP - e0239532 JF - PloS one JO - PLoS One VL - 15 IS - 9 N2 - To investigate the clinical value of changes in the subtypes of peripheral blood lymphocytes and levels of inflammatory cytokines in patients with COVID-19, the total numbers of lymphocytes and CD4+ lymphocytes and the ratio of CD4+/CD8+ lymphocytes were calculated and observed in different groups of patients with COVID-19. The results show that the lymphocytopenia in patients with COVID-19 was mainly manifested by decreases in the CD4+ T lymphocyte number and the CD4+/CD8+ ratio. The decreased number of CD4+ T lymphocytes and the elevated levels of TNF-α and IL-6 were correlated with the severity of COVID-19 disease. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/32976531/The_changes_of_the_peripheral_CD4+_lymphocytes_and_inflammatory_cytokines_in_Patients_with_COVID_19_ L2 - https://dx.plos.org/10.1371/journal.pone.0239532 DB - PRIME DP - Unbound Medicine ER -