Tags

Type your tag names separated by a space and hit enter

Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action.
Life Sci. 2020 Dec 01; 262:118493.LS

Abstract

The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely used in basic science and in a variety of clinical trials. MSCs are able to engraft to the damaged tissues after transplantation and promote tissue regeneration, besides MSCs able to secrete immunomodulatory factors that suppress the cytokine storms. Moreover, the contribution of MSCs to prevent cell death and inhibit tissue fibrosis is well established. In the current review article, the potential mechanisms by which MSCs contribute to the treatment of COVID-19 patients are highlighted. Also, current trials that evaluated the potential of MSC-based treatments for COVID-19 are briefly reviewed.

Authors+Show Affiliations

Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.UQ Diamantina Institute, Translational Research Institute, The University of Queensland, Brisbane, Queensland, Australia. Electronic address: a.shafiee@uq.edu.au.Department of Immunology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: smmhashemi@sbmu.ac.ir.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32979360

Citation

Sadeghi, Somaye, et al. "Mesenchymal Stem Cell Therapies for COVID-19: Current Status and Mechanism of Action." Life Sciences, vol. 262, 2020, p. 118493.
Sadeghi S, Soudi S, Shafiee A, et al. Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action. Life Sci. 2020;262:118493.
Sadeghi, S., Soudi, S., Shafiee, A., & Hashemi, S. M. (2020). Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action. Life Sciences, 262, 118493. https://doi.org/10.1016/j.lfs.2020.118493
Sadeghi S, et al. Mesenchymal Stem Cell Therapies for COVID-19: Current Status and Mechanism of Action. Life Sci. 2020 Dec 1;262:118493. PubMed PMID: 32979360.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action. AU - Sadeghi,Somaye, AU - Soudi,Sara, AU - Shafiee,Abbas, AU - Hashemi,Seyed Mahmoud, Y1 - 2020/09/23/ PY - 2020/07/21/received PY - 2020/09/19/revised PY - 2020/09/20/accepted PY - 2020/9/27/pubmed PY - 2020/9/27/medline PY - 2020/9/26/entrez KW - Cell therapy KW - Clinical trials KW - Coronavirus KW - Cytokine storm KW - Immunomodulatory effects SP - 118493 EP - 118493 JF - Life sciences JO - Life Sci VL - 262 N2 - The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for COVID-19. Therefore, there is a crucial unmet need to develop a safe and effective treatment for COVID-19 patients. Mesenchymal stem cells (MSCs) are widely used in basic science and in a variety of clinical trials. MSCs are able to engraft to the damaged tissues after transplantation and promote tissue regeneration, besides MSCs able to secrete immunomodulatory factors that suppress the cytokine storms. Moreover, the contribution of MSCs to prevent cell death and inhibit tissue fibrosis is well established. In the current review article, the potential mechanisms by which MSCs contribute to the treatment of COVID-19 patients are highlighted. Also, current trials that evaluated the potential of MSC-based treatments for COVID-19 are briefly reviewed. SN - 1879-0631 UR - https://www.unboundmedicine.com/medline/citation/32979360/Mesenchymal_stem_cell_therapies_for_COVID_19:_Current_status_and_mechanism_of_action_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(20)31246-7 DB - PRIME DP - Unbound Medicine ER -