Tags

Type your tag names separated by a space and hit enter

Towards accelerated quantitative sodium MRI at 7 T in the skeletal muscle: Comparison of anisotropic acquisition- and compressed sensing techniques.
Magn Reson Imaging. 2020 Sep 23 [Online ahead of print]MR

Abstract

PURPOSE

To compare three anisotropic acquisition schemes and three compressed sensing (CS) approaches for accelerated tissue sodium concentration (TSC) quantification using 23Na MRI at 7 T.

MATERIALS AND METHODS

Three anisotropic 3D-radial acquisition sequences were evaluated using simulations, phantom- and in vivo TSC measurements: An anisotropic density-adapted 3D-radial sequence (3DPR-C), a 3D acquisition-weighted density-adapted stack-of-stars sampling scheme (SOS) and an SOS approach with golden-ratio rotation (SOS-GR). Eight healthy volunteers were examined at a 7 Tesla MRI system. TSC measurements of the calf were conducted with a nominal spatial resolution of Δx = (3.0 × 3.0 × 15.0) mm3 and a field of view of (156.0 × 156.0 × 240.0) mm3 for multiple undersampling factors (USF). Three CS reconstructions were evaluated: Total variation CS (TV-CS), 3D Dictionary-Learning compressed sensing (3D-DLCS) and TV-CS with a block matching prior (TV-BL-CS). Results of the simulations and measurements were compared to a simulated ground truth (GT) or a fully sampled reference measurement (FS), respectively. The deviation of the mean TSC evaluated in multiple ROI (mEGT/FS) and the Normalized-Root-Mean-Squared-Error (NRMSE) for simulations were evaluated for CS and NUFFT reconstructions.

RESULTS

In simulations, the SOS-GR yielded the lowest NRMSE and mEGT (< 4%) for an acquisition time (TA) of less than 2 min. CS further improved the results. In simulations and measurements, the best TSC quantification results were obtained with 3D-DLCS and SOS-GR (lowest NRMSE, mEGT < 2.6% in simulations, mEGT < 10.7% for phantom measurements and mEFS < 6 % in vivo) with an USF = 4.1 (TA < 2 min). TV-CS showed no or only slight improvements to NUFFT. The results of TV-BL-CS were similar to 3D-DLCS.

DISCUSSION

The TA for TSC measurements could be reduced to less than 2 min. by using adapted sequences such as SOS-GR and CS reconstruction approaches such as 3D-DLCS or TV-BL-CS, while the quantitative accuracy stays comparable to a fully sampled NUFFT reconstruction (approx. 8 min. TA). In future, the lower TA could improve clinical applicability of TSC measurements.

Authors+Show Affiliations

Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany. Electronic address: matthias.utzschneider@uk-erlangen.de.Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Pattern Recognition Lab, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.Institute of Radiology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany; Institute of Medical Physics, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Erlangen, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32979516

Citation

Utzschneider, Matthias, et al. "Towards Accelerated Quantitative Sodium MRI at 7 T in the Skeletal Muscle: Comparison of Anisotropic Acquisition- and Compressed Sensing Techniques." Magnetic Resonance Imaging, 2020.
Utzschneider M, Müller M, Gast LV, et al. Towards accelerated quantitative sodium MRI at 7 T in the skeletal muscle: Comparison of anisotropic acquisition- and compressed sensing techniques. Magn Reson Imaging. 2020.
Utzschneider, M., Müller, M., Gast, L. V., Lachner, S., Behl, N. G. R., Maier, A., Uder, M., & Nagel, A. M. (2020). Towards accelerated quantitative sodium MRI at 7 T in the skeletal muscle: Comparison of anisotropic acquisition- and compressed sensing techniques. Magnetic Resonance Imaging. https://doi.org/10.1016/j.mri.2020.09.019
Utzschneider M, et al. Towards Accelerated Quantitative Sodium MRI at 7 T in the Skeletal Muscle: Comparison of Anisotropic Acquisition- and Compressed Sensing Techniques. Magn Reson Imaging. 2020 Sep 23; PubMed PMID: 32979516.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Towards accelerated quantitative sodium MRI at 7 T in the skeletal muscle: Comparison of anisotropic acquisition- and compressed sensing techniques. AU - Utzschneider,Matthias, AU - Müller,Max, AU - Gast,Lena V, AU - Lachner,Sebastian, AU - Behl,Nicolas G R, AU - Maier,Andreas, AU - Uder,Michael, AU - Nagel,Armin M, Y1 - 2020/09/23/ PY - 2020/05/08/received PY - 2020/08/25/revised PY - 2020/09/14/accepted PY - 2020/9/26/entrez PY - 2020/9/27/pubmed PY - 2020/9/27/medline KW - 7 tesla KW - Anisotropic acquisition schemes KW - Compressed sensing KW - Image reconstruction KW - Skeletal muscle KW - Sodium (23Na) magnetic resonance imaging JF - Magnetic resonance imaging JO - Magn Reson Imaging N2 - PURPOSE: To compare three anisotropic acquisition schemes and three compressed sensing (CS) approaches for accelerated tissue sodium concentration (TSC) quantification using 23Na MRI at 7 T. MATERIALS AND METHODS: Three anisotropic 3D-radial acquisition sequences were evaluated using simulations, phantom- and in vivo TSC measurements: An anisotropic density-adapted 3D-radial sequence (3DPR-C), a 3D acquisition-weighted density-adapted stack-of-stars sampling scheme (SOS) and an SOS approach with golden-ratio rotation (SOS-GR). Eight healthy volunteers were examined at a 7 Tesla MRI system. TSC measurements of the calf were conducted with a nominal spatial resolution of Δx = (3.0 × 3.0 × 15.0) mm3 and a field of view of (156.0 × 156.0 × 240.0) mm3 for multiple undersampling factors (USF). Three CS reconstructions were evaluated: Total variation CS (TV-CS), 3D Dictionary-Learning compressed sensing (3D-DLCS) and TV-CS with a block matching prior (TV-BL-CS). Results of the simulations and measurements were compared to a simulated ground truth (GT) or a fully sampled reference measurement (FS), respectively. The deviation of the mean TSC evaluated in multiple ROI (mEGT/FS) and the Normalized-Root-Mean-Squared-Error (NRMSE) for simulations were evaluated for CS and NUFFT reconstructions. RESULTS: In simulations, the SOS-GR yielded the lowest NRMSE and mEGT (< 4%) for an acquisition time (TA) of less than 2 min. CS further improved the results. In simulations and measurements, the best TSC quantification results were obtained with 3D-DLCS and SOS-GR (lowest NRMSE, mEGT < 2.6% in simulations, mEGT < 10.7% for phantom measurements and mEFS < 6 % in vivo) with an USF = 4.1 (TA < 2 min). TV-CS showed no or only slight improvements to NUFFT. The results of TV-BL-CS were similar to 3D-DLCS. DISCUSSION: The TA for TSC measurements could be reduced to less than 2 min. by using adapted sequences such as SOS-GR and CS reconstruction approaches such as 3D-DLCS or TV-BL-CS, while the quantitative accuracy stays comparable to a fully sampled NUFFT reconstruction (approx. 8 min. TA). In future, the lower TA could improve clinical applicability of TSC measurements. SN - 1873-5894 UR - https://www.unboundmedicine.com/medline/citation/32979516/Towards_accelerated_quantitative_sodium_MRI_at_7 T_in_the_skeletal_muscle:_Comparison_of_anisotropic_acquisition__and_compressed_sensing_techniques_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0730-725X(20)30305-2 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.