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The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials.
Cytokine. 2020 12; 136:155282.C

Abstract

BACKGROUND

Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effect of soy products on inflammatory markers.

METHODS

Following electronic databases were searched up to March 2020: PubMed, Scopus, ISI web of science, and Cochrane Library All randomized trials which assessed the effect of soy product supplementation on c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were included for last analysis. Treatment effects were expressed as mean difference (MD) and the standard deviation (SD) of outcomes. To estimate the overall effect the random-effects model was employed.

RESULTS

Finally, 51 randomized trial were included for present study. Last analysis showed that soy product supplementation lead to significant reduction in CRP (MD -0.27 mg/L; 95% CI: -0.51, -0.02, p = 0.028) but it did not affect IL-6 (MD 0.0 pg/ml; 95% CI: -0.06, 0.06, p = 0.970) and TNF-α (MD = -0.04 pg/ml; 95% CI: -0.11, 0.03, p = 0.252). Subgroup analysis showed that soy supplementation had a significant impact on decreasing IL-6 and TNF-α levels when studies had a long-term intervention (≥12 weeks) and used low dose isoflavone (<100 mg/day).

CONCLUSION

In conclusion, present systematic review and meta-analysis found a significant reduction in CRP levels after soy supplementation whiles IL-6 and TNF-α did not affect.

Authors+Show Affiliations

Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Student Research Committee, Lorestan University of Medical Sciences, Khorramabad, Iran.Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Nutrition, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran.School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran.Department of Clinical Nutrition, School of Nutritional Science, Tehran University of Medical Science, Tehran, Iran.Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran; Students' Scientific Research Center (SSRC), Tehran University of Medical Sciences (TUMS), Tehran, Iran. Electronic address: ehsanghaedi073@gmail.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

32979840

Citation

Asbaghi, Omid, et al. "The Effects of Soy Supplementation On Inflammatory Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Cytokine, vol. 136, 2020, p. 155282.
Asbaghi O, Yaghubi E, Nazarian B, et al. The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Cytokine. 2020;136:155282.
Asbaghi, O., Yaghubi, E., Nazarian, B., Kelishadi, M. R., Khadem, H., Moodi, V., Naeini, F., & Ghaedi, E. (2020). The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. Cytokine, 136, 155282. https://doi.org/10.1016/j.cyto.2020.155282
Asbaghi O, et al. The Effects of Soy Supplementation On Inflammatory Biomarkers: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Cytokine. 2020;136:155282. PubMed PMID: 32979840.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of soy supplementation on inflammatory biomarkers: A systematic review and meta-analysis of randomized controlled trials. AU - Asbaghi,Omid, AU - Yaghubi,Elham, AU - Nazarian,Behzad, AU - Kelishadi,Mahnaz Rezaei, AU - Khadem,Hossein, AU - Moodi,Vihan, AU - Naeini,Fatemeh, AU - Ghaedi,Ehsan, Y1 - 2020/09/24/ PY - 2020/04/07/received PY - 2020/08/20/revised PY - 2020/09/02/accepted PY - 2020/9/27/pubmed PY - 2021/11/27/medline PY - 2020/9/26/entrez KW - CRP KW - Genistein KW - Inflammation KW - Meta-analysis KW - Soy KW - Systematic review SP - 155282 EP - 155282 JF - Cytokine JO - Cytokine VL - 136 N2 - BACKGROUND: Soy products contain several compounds with anti-inflammatory properties like genistein and daidzein which reported to act through different pathways. Present study conducted considering the inconsistent results and lack of any comprehensive review regarding randomized controlled trials which assess the effect of soy products on inflammatory markers. METHODS: Following electronic databases were searched up to March 2020: PubMed, Scopus, ISI web of science, and Cochrane Library All randomized trials which assessed the effect of soy product supplementation on c-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) were included for last analysis. Treatment effects were expressed as mean difference (MD) and the standard deviation (SD) of outcomes. To estimate the overall effect the random-effects model was employed. RESULTS: Finally, 51 randomized trial were included for present study. Last analysis showed that soy product supplementation lead to significant reduction in CRP (MD -0.27 mg/L; 95% CI: -0.51, -0.02, p = 0.028) but it did not affect IL-6 (MD 0.0 pg/ml; 95% CI: -0.06, 0.06, p = 0.970) and TNF-α (MD = -0.04 pg/ml; 95% CI: -0.11, 0.03, p = 0.252). Subgroup analysis showed that soy supplementation had a significant impact on decreasing IL-6 and TNF-α levels when studies had a long-term intervention (≥12 weeks) and used low dose isoflavone (<100 mg/day). CONCLUSION: In conclusion, present systematic review and meta-analysis found a significant reduction in CRP levels after soy supplementation whiles IL-6 and TNF-α did not affect. SN - 1096-0023 UR - https://www.unboundmedicine.com/medline/citation/32979840/The_effects_of_soy_supplementation_on_inflammatory_biomarkers:_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(20)30298-2 DB - PRIME DP - Unbound Medicine ER -