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Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt.
Clin Ophthalmol. 2020; 14:2701-2708.CO

Abstract

Purpose

To assess SARS-CoV-2 virus in conjunctival tears and secretions of positive confirmed COVID-19 patients.

Methods

A case series study that included 28 positive COVID-19 patients confirmed with nasopharyngeal swab in the period 18-28 May 2020 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions of these confirmed positive cases were collected with disposable sampling swabs at interval of 3 days after admission due to respiratory symptoms. They were examined for the presence of SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT-PCR) assay.

Results

Thirteen (46.43%) patients were stable, 4 (14.28%) patients suffered from dyspnea, 3 (10.72%) patients suffered from high fever, 5 (17.85%) patients suffered from cough, and 3 (10.72%) patients were on mechanical ventilation. Ten (35.71%) patients suffered from conjunctivitis. Tear and conjunctival swabs were positive in 8 (28.57%) patients, while other patients' swabs were negative (71.43%). Out of 10 patients with conjunctival manifestations, 3 patients had SARS-CoV-2 in their conjunctiva using (RT-PCR) test. Out of the 18 patients with no conjunctival manifestations, 5 patients had positive SARS-CoV-2 in their conjunctiva using (RT-PCR) test.

Conclusion

The SARS-CoV-2 virus could be found in tears and conjunctival secretions in SARS-CoV-2 patients with or without conjunctivitis.

Authors+Show Affiliations

Sohag Faculty of Medicine, Ophthalmology Department, Sohag University, Sohag, Egypt.Sohag Faculty of Medicine, Ophthalmology Department, Sohag University, Sohag, Egypt.Tropical Medicine, Sohag Tropical Medicine Hospital, Sohag, Egypt.Microbiology and Immunology, Department of Microbiology, Aswan University, Aswan, Egypt.Clinical Pathology Department, Sohag University, Sohag, Egypt.Sohag Faculty of Medicine, Ophthalmology Department, Sohag University, Sohag, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32982162

Citation

Mahmoud, Hany, et al. "Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients With SARS-CoV-2 Infection in Sohag Province, Egypt." Clinical Ophthalmology (Auckland, N.Z.), vol. 14, 2020, pp. 2701-2708.
Mahmoud H, Ammar H, El Rashidy A, et al. Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt. Clinical ophthalmology (Auckland, N.Z.). 2020;14:2701-2708.
Mahmoud, H., Ammar, H., El Rashidy, A., Ali, A. H., Hefny, H. M., & Mounir, A. (2020). Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt. Clinical Ophthalmology (Auckland, N.Z.), 14, 2701-2708. https://doi.org/10.2147/OPTH.S270006
Mahmoud H, et al. Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients With SARS-CoV-2 Infection in Sohag Province, Egypt. Clinical ophthalmology (Auckland, N.Z.). 2020;14:2701-2708. PubMed PMID: 32982162.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of Coronavirus in the Conjunctival Tears and Secretions in Patients with SARS-CoV-2 Infection in Sohag Province, Egypt. AU - Mahmoud,Hany, AU - Ammar,Hatem, AU - El Rashidy,Amr, AU - Ali,Amal H, AU - Hefny,Hesham M, AU - Mounir,Amr, Y1 - 2020/09/15/ PY - 2020/07/01/received PY - 2020/08/31/accepted PY - 2020/9/28/entrez PY - 2020/9/29/pubmed PY - 2020/9/29/medline KW - RT‐PCR KW - SARS-CoV-2 KW - conjunctiva KW - conjunctival secretions KW - swab KW - tears SP - 2701 EP - 2708 JF - Clinical ophthalmology (Auckland, N.Z.) VL - 14 N2 - Purpose: To assess SARS-CoV-2 virus in conjunctival tears and secretions of positive confirmed COVID-19 patients. Methods: A case series study that included 28 positive COVID-19 patients confirmed with nasopharyngeal swab in the period 18-28 May 2020 at Sohag Tropical Medicine Hospital. Tears and conjunctival secretions of these confirmed positive cases were collected with disposable sampling swabs at interval of 3 days after admission due to respiratory symptoms. They were examined for the presence of SARS-CoV-2 by reverse transcription-polymerase chain reaction (RT-PCR) assay. Results: Thirteen (46.43%) patients were stable, 4 (14.28%) patients suffered from dyspnea, 3 (10.72%) patients suffered from high fever, 5 (17.85%) patients suffered from cough, and 3 (10.72%) patients were on mechanical ventilation. Ten (35.71%) patients suffered from conjunctivitis. Tear and conjunctival swabs were positive in 8 (28.57%) patients, while other patients' swabs were negative (71.43%). Out of 10 patients with conjunctival manifestations, 3 patients had SARS-CoV-2 in their conjunctiva using (RT-PCR) test. Out of the 18 patients with no conjunctival manifestations, 5 patients had positive SARS-CoV-2 in their conjunctiva using (RT-PCR) test. Conclusion: The SARS-CoV-2 virus could be found in tears and conjunctival secretions in SARS-CoV-2 patients with or without conjunctivitis. SN - 1177-5467 UR - https://www.unboundmedicine.com/medline/citation/32982162/Assessment_of_Coronavirus_in_the_Conjunctival_Tears_and_Secretions_in_Patients_with_SARS_CoV_2_Infection_in_Sohag_Province_Egypt_ L2 - https://dx.doi.org/10.2147/OPTH.S270006 DB - PRIME DP - Unbound Medicine ER -
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