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Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in".
Front Immunol. 2020; 11:2132.FI

Abstract

In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent of a severe respiratory infection named SARS-CoV-2, and it has since been recognized worldwide as a pandemic. There are still numerous doubts concerning its pathogenesis and particularly the underlying causes of the various clinical courses, ranging from severe manifestations to asymptomatic forms, including acute respiratory distress syndrome. The major factor responsible for acute respiratory distress syndrome is the so-called "cytokine storm," which is an aberrant response from the host immune system that induces an exaggerated release of proinflammatory cytokines/chemokines. In this review, we will discuss the role of cytokine storm in COVID-19 and potential treatments with which counteract this aberrant response, which may be valuable in the clinical translation.

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Authors+Show Affiliations

Castelli V
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Cimini A
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Ferri C
Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.

MeSH

AnimalsAntibodies, Monoclonal, HumanizedBetacoronavirusCOVID-19ChemokinesCoronavirus InfectionsGlucocorticoidsHumansHydroxychloroquineInterleukin 1 Receptor Antagonist ProteinPandemicsPneumonia, ViralReceptors, Interleukin-6Respiratory Distress SyndromeSARS-CoV-2

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32983172

Citation

Castelli, Vanessa, et al. "Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked In"." Frontiers in Immunology, vol. 11, 2020, p. 2132.
Castelli V, Cimini A, Ferri C. Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in". Front Immunol. 2020;11:2132.
Castelli, V., Cimini, A., & Ferri, C. (2020). Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in". Frontiers in Immunology, 11, 2132. https://doi.org/10.3389/fimmu.2020.02132
Castelli V, Cimini A, Ferri C. Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked In". Front Immunol. 2020;11:2132. PubMed PMID: 32983172.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytokine Storm in COVID-19: "When You Come Out of the Storm, You Won't Be the Same Person Who Walked in". AU - Castelli,Vanessa, AU - Cimini,Annamaria, AU - Ferri,Claudio, Y1 - 2020/09/02/ PY - 2020/6/18/received PY - 2020/8/6/accepted PY - 2020/9/28/entrez PY - 2020/9/29/pubmed PY - 2020/10/21/medline KW - SARS-CoV2 KW - acute respiratory distress KW - coronavirus KW - cytokines KW - inflammation KW - severity SP - 2132 EP - 2132 JF - Frontiers in immunology JO - Front Immunol VL - 11 N2 - In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal agent of a severe respiratory infection named SARS-CoV-2, and it has since been recognized worldwide as a pandemic. There are still numerous doubts concerning its pathogenesis and particularly the underlying causes of the various clinical courses, ranging from severe manifestations to asymptomatic forms, including acute respiratory distress syndrome. The major factor responsible for acute respiratory distress syndrome is the so-called "cytokine storm," which is an aberrant response from the host immune system that induces an exaggerated release of proinflammatory cytokines/chemokines. In this review, we will discuss the role of cytokine storm in COVID-19 and potential treatments with which counteract this aberrant response, which may be valuable in the clinical translation. SN - 1664-3224 UR - https://www.unboundmedicine.com/medline/citation/32983172/Cytokine_Storm_in_COVID_19:_"When_You_Come_Out_of_the_Storm_You_Won't_Be_the_Same_Person_Who_Walked_in"_ DB - PRIME DP - Unbound Medicine ER -