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5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects.
J Clin Psychopharmacol 1987; 7(3):127-37JC

Abstract

Alterations in serotonin metabolism may be an important factor in the etiology and treatment of depression. In this regard, 5-hydroxytryptophan (5-HTP), a serotonin precursor, has been given to patients with depression. Although a review of these studies suggests that 5-HTP possesses antidepressant properties, additional trials are clearly indicated. Following a discussion of the pharmacology of 5-HTP, the authors highlight adverse effects associated with its administration to depressed patients, neurologic subjects, and normal individuals. Relatively few adverse effects are associated with its use in the treatment of depressed patients.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Review

Language

eng

PubMed ID

3298325

Citation

Byerley, W F., et al. "5-Hydroxytryptophan: a Review of Its Antidepressant Efficacy and Adverse Effects." Journal of Clinical Psychopharmacology, vol. 7, no. 3, 1987, pp. 127-37.
Byerley WF, Judd LL, Reimherr FW, et al. 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. J Clin Psychopharmacol. 1987;7(3):127-37.
Byerley, W. F., Judd, L. L., Reimherr, F. W., & Grosser, B. I. (1987). 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. Journal of Clinical Psychopharmacology, 7(3), pp. 127-37.
Byerley WF, et al. 5-Hydroxytryptophan: a Review of Its Antidepressant Efficacy and Adverse Effects. J Clin Psychopharmacol. 1987;7(3):127-37. PubMed PMID: 3298325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-Hydroxytryptophan: a review of its antidepressant efficacy and adverse effects. AU - Byerley,W F, AU - Judd,L L, AU - Reimherr,F W, AU - Grosser,B I, PY - 1987/6/1/pubmed PY - 1987/6/1/medline PY - 1987/6/1/entrez SP - 127 EP - 37 JF - Journal of clinical psychopharmacology JO - J Clin Psychopharmacol VL - 7 IS - 3 N2 - Alterations in serotonin metabolism may be an important factor in the etiology and treatment of depression. In this regard, 5-hydroxytryptophan (5-HTP), a serotonin precursor, has been given to patients with depression. Although a review of these studies suggests that 5-HTP possesses antidepressant properties, additional trials are clearly indicated. Following a discussion of the pharmacology of 5-HTP, the authors highlight adverse effects associated with its administration to depressed patients, neurologic subjects, and normal individuals. Relatively few adverse effects are associated with its use in the treatment of depressed patients. SN - 0271-0749 UR - https://www.unboundmedicine.com/medline/citation/3298325/5_Hydroxytryptophan:_a_review_of_its_antidepressant_efficacy_and_adverse_effects_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3298325.ui DB - PRIME DP - Unbound Medicine ER -