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SARS-CoV-2: Zoonotic origin of pandemic coronavirus.
Acta Virol. 2020; 64(3):281-287.AV

Abstract

A novel disease, of unknown origin, causing a deadly pneumonia of human patients was reported in December 2019 in Wuhan, Hubei province of China. Later called coronavirus disease (COVID-19), it rapidly spread across China and worldwide. Intensive research revealed that the etiological agent of the global COVID-19 pandemic was a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 genome contains typical coronavirus genes but the receptor binding domain (RBD) in the S protein is highly specific. The site for furin-like protease cleavage of the S protein into S1 and S2 subunits is also unique. Further analyses suggested that SARS-CoV-2 is of zoonotic origin. The analysis of the SARS-CoV-2 genome, especially the S gene, shows that natural evolutionary process between a bat-CoV and a pangolin-CoV or other animal coronavirus could have been important in creating SARS-CoV-2, with transmission of novel virus to the human population. On the other hand, new analyses indicate that SARS-CoV-2 is not a recombinant virus. Keywords: COVID-19; SARS-CoV-2; genome; bat coronavirus; pangolin coronavirus.

Authors

No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32985202

Citation

Vilcek, S. "SARS-CoV-2: Zoonotic Origin of Pandemic Coronavirus." Acta Virologica, vol. 64, no. 3, 2020, pp. 281-287.
Vilcek S. SARS-CoV-2: Zoonotic origin of pandemic coronavirus. Acta Virol. 2020;64(3):281-287.
Vilcek, S. (2020). SARS-CoV-2: Zoonotic origin of pandemic coronavirus. Acta Virologica, 64(3), 281-287. https://doi.org/10.4149/av_2020_302
Vilcek S. SARS-CoV-2: Zoonotic Origin of Pandemic Coronavirus. Acta Virol. 2020;64(3):281-287. PubMed PMID: 32985202.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SARS-CoV-2: Zoonotic origin of pandemic coronavirus. A1 - Vilcek,S, PY - 2020/9/29/pubmed PY - 2020/10/27/medline PY - 2020/9/28/entrez SP - 281 EP - 287 JF - Acta virologica JO - Acta Virol VL - 64 IS - 3 N2 - A novel disease, of unknown origin, causing a deadly pneumonia of human patients was reported in December 2019 in Wuhan, Hubei province of China. Later called coronavirus disease (COVID-19), it rapidly spread across China and worldwide. Intensive research revealed that the etiological agent of the global COVID-19 pandemic was a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The SARS-CoV-2 genome contains typical coronavirus genes but the receptor binding domain (RBD) in the S protein is highly specific. The site for furin-like protease cleavage of the S protein into S1 and S2 subunits is also unique. Further analyses suggested that SARS-CoV-2 is of zoonotic origin. The analysis of the SARS-CoV-2 genome, especially the S gene, shows that natural evolutionary process between a bat-CoV and a pangolin-CoV or other animal coronavirus could have been important in creating SARS-CoV-2, with transmission of novel virus to the human population. On the other hand, new analyses indicate that SARS-CoV-2 is not a recombinant virus. Keywords: COVID-19; SARS-CoV-2; genome; bat coronavirus; pangolin coronavirus. SN - 0001-723X UR - https://www.unboundmedicine.com/medline/citation/32985202/SARS_CoV_2:_Zoonotic_origin_of_pandemic_coronavirus_ L2 - http://www.aepress.sk/_downloads/dl.php?from=pubmed&journal=AV&file=2020_03_281.pdf DB - PRIME DP - Unbound Medicine ER -