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Comparison of clinical characteristics between coronavirus disease 2019 pneumonia and community-acquired pneumonia.
Curr Med Res Opin. 2020 11; 36(11):1747-1752.CM

Abstract

OBJECTIVE

Coronavirus disease 2019 (COVID-19) has high morbidity and mortality, and spreads rapidly in the community to result in a large number of infection cases. This study aimed to compare clinical features in adult patients with coronavirus disease 2019 (COVID-19) pneumonia to those in adult patients with community-acquired pneumonia (CAP).

METHODS

Clinical presentations, laboratory findings, imaging features, complications, treatment and outcomes were compared between patients with COVID-19 pneumonia and patients with CAP. The study group of patients with COVID-19 pneumonia consisted of 120 patients. One hundred and thirty-four patients with CAP were enrolled for comparison.

RESULTS

Patients with COVID-19 pneumonia had lower levels of abnormal laboratory parameters (white blood cell count, lymphocyte count, procalcitonin level, erythrocyte sedimentation rate and C-reactive protein level) and more extensive radiographic involvement. More severe respiratory compromise resulted in a higher rate of intensive care unit admission, acute respiratory distress syndrome (ARDS) and mechanical ventilation (36% vs 15%, 34% vs 15% and 32% vs 12%, respectively; all p < .05). The 30 day mortality was more than twice as high in patients with COVID-19 pneumonia (12% versus 5%; p = .063), despite not reaching a statistically significant difference.

CONCLUSIONS

Lower levels of abnormal laboratory parameters, more extensive radiographic involvement, more severe respiratory compromise, and higher rates of ICU admission, ARDS and mechanical ventilation are key characteristics that distinguish patients with COVID-19-associated pneumonia from patients with CAP.

Authors+Show Affiliations

Department of Respiratory Medicine, West China Hospital Sichuan University-Ziyang Hospital, The First People's Hospital of Ziyang, Ziyang, China.Department of Radiology, Shenzhen Second People's Hospital, Shenzhen, China.Department of Radiology, The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, China.Department of Respiratory Medicine, Deyang Fifth Hospital, Deyang City, China.Department of Ophthalmology, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.Department of Internal Medicine, Charité-Universitätsmedizin Berlin, German Heart Center Berlin, Berlin, Germany.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32986475

Citation

Tian, Juncai, et al. "Comparison of Clinical Characteristics Between Coronavirus Disease 2019 Pneumonia and Community-acquired Pneumonia." Current Medical Research and Opinion, vol. 36, no. 11, 2020, pp. 1747-1752.
Tian J, Xu Q, Liu S, et al. Comparison of clinical characteristics between coronavirus disease 2019 pneumonia and community-acquired pneumonia. Curr Med Res Opin. 2020;36(11):1747-1752.
Tian, J., Xu, Q., Liu, S., Mao, L., Wang, M., & Hou, X. (2020). Comparison of clinical characteristics between coronavirus disease 2019 pneumonia and community-acquired pneumonia. Current Medical Research and Opinion, 36(11), 1747-1752. https://doi.org/10.1080/03007995.2020.1830050
Tian J, et al. Comparison of Clinical Characteristics Between Coronavirus Disease 2019 Pneumonia and Community-acquired Pneumonia. Curr Med Res Opin. 2020;36(11):1747-1752. PubMed PMID: 32986475.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of clinical characteristics between coronavirus disease 2019 pneumonia and community-acquired pneumonia. AU - Tian,Juncai, AU - Xu,Qizhong, AU - Liu,Song, AU - Mao,Lingli, AU - Wang,Maoren, AU - Hou,Xuewen, Y1 - 2020/10/13/ PY - 2020/9/29/pubmed PY - 2020/11/20/medline PY - 2020/9/28/entrez KW - COVID-19 pneumonia KW - SARS-CoV-2 KW - clinical characteristics KW - community-acquired pneumonia SP - 1747 EP - 1752 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 36 IS - 11 N2 - OBJECTIVE: Coronavirus disease 2019 (COVID-19) has high morbidity and mortality, and spreads rapidly in the community to result in a large number of infection cases. This study aimed to compare clinical features in adult patients with coronavirus disease 2019 (COVID-19) pneumonia to those in adult patients with community-acquired pneumonia (CAP). METHODS: Clinical presentations, laboratory findings, imaging features, complications, treatment and outcomes were compared between patients with COVID-19 pneumonia and patients with CAP. The study group of patients with COVID-19 pneumonia consisted of 120 patients. One hundred and thirty-four patients with CAP were enrolled for comparison. RESULTS: Patients with COVID-19 pneumonia had lower levels of abnormal laboratory parameters (white blood cell count, lymphocyte count, procalcitonin level, erythrocyte sedimentation rate and C-reactive protein level) and more extensive radiographic involvement. More severe respiratory compromise resulted in a higher rate of intensive care unit admission, acute respiratory distress syndrome (ARDS) and mechanical ventilation (36% vs 15%, 34% vs 15% and 32% vs 12%, respectively; all p < .05). The 30 day mortality was more than twice as high in patients with COVID-19 pneumonia (12% versus 5%; p = .063), despite not reaching a statistically significant difference. CONCLUSIONS: Lower levels of abnormal laboratory parameters, more extensive radiographic involvement, more severe respiratory compromise, and higher rates of ICU admission, ARDS and mechanical ventilation are key characteristics that distinguish patients with COVID-19-associated pneumonia from patients with CAP. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/32986475/Comparison_of_clinical_characteristics_between_coronavirus_disease_2019_pneumonia_and_community_acquired_pneumonia_ DB - PRIME DP - Unbound Medicine ER -