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Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic.
Vaccine. 2020 10 21; 38(45):7002-7006.V

Abstract

INTRODUCTION

The world is facing the COVID-19 pandemic. The development of a vaccine is challenging. We aimed to determine the proportion of people who intend to get vaccinated against COVID-19 in France or to participate in a vaccine clinical trial.

METHODS

We conducted an anonymous on-line survey from the 26th of March to the 20th of April 2020. Primary endpoints were the intention to get vaccinated against COVID-19 if a vaccine was available or participate in a vaccine clinical trial.

RESULTS

Three thousand two hundred and fifty nine individuals answered the survey; women accounted for 67.4% of the respondents. According to their statements, 2.512 participants (77.6%, 95% CI 76.2-79%) will certainly or probably agree to get vaccinated against COVID-19. Older age, male gender, fear about COVID-19, being a healthcare worker and individual perceived risk were associated with COVID-19 vaccine acceptance. Vaccine hesitancy was associated with a decrease in COVID-19 vaccine acceptance. One thousand and five hundred and fifty respondents (47.6% 95% CI 45.9-49.3%) will certainly or probably agree to participate in a COVID-19 vaccine clinical trial. Older age, male gender, being a healthcare worker and individual perceived risk were associated with potential acceptance to participate in a COVID-19 vaccine clinical trial. Vaccine hesitancy was associated with refusal for participation in a COVID-19 vaccine clinical trial.

CONCLUSIONS

Nearly 75% and 48% of the survey respondents were respectively likely to accept vaccination or participation in a clinical trial against COVID-19. Vaccine hesitancy will be the major barrier to COVID-19 vaccine uptake.

Authors+Show Affiliations

Centre d'investigation clinique-INSERM 1408, University Hospital of Saint-Etienne, France.Centre d'investigation clinique-INSERM 1408, University Hospital of Saint-Etienne, France; Department of General Practice, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, Université de Lyon, Saint-Etienne, France; PRESAGE Insitute, Université de Lyon, Saint-Etienne, France.Centre d'investigation clinique-INSERM 1408, University Hospital of Saint-Etienne, France; Department of General Practice, Faculté de Médecine Jacques Lisfranc, Université Jean Monnet, Université de Lyon, Saint-Etienne, France; PRESAGE Insitute, Université de Lyon, Saint-Etienne, France.Centre d'investigation clinique-INSERM 1408, University Hospital of Saint-Etienne, France.Centre d'investigation clinique-INSERM 1408, University Hospital of Saint-Etienne, France; Groupe Immunité des Muqueuses et Agents Pathogènes, Université Jean Monnet, Université de Lyon, Saint-Etienne, France; PRESAGE Insitute, Université de Lyon, Saint-Etienne, France.Centre d'investigation clinique-INSERM 1408, University Hospital of Saint-Etienne, France; Groupe Immunité des Muqueuses et Agents Pathogènes, Université Jean Monnet, Université de Lyon, Saint-Etienne, France; PRESAGE Insitute, Université de Lyon, Saint-Etienne, France. Electronic address: amandine.gagneux-brunon@chu-st-etienne.fr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

32988688

Citation

Detoc, Maëlle, et al. "Intention to Participate in a COVID-19 Vaccine Clinical Trial and to Get Vaccinated Against COVID-19 in France During the Pandemic." Vaccine, vol. 38, no. 45, 2020, pp. 7002-7006.
Detoc M, Bruel S, Frappe P, et al. Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic. Vaccine. 2020;38(45):7002-7006.
Detoc, M., Bruel, S., Frappe, P., Tardy, B., Botelho-Nevers, E., & Gagneux-Brunon, A. (2020). Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic. Vaccine, 38(45), 7002-7006. https://doi.org/10.1016/j.vaccine.2020.09.041
Detoc M, et al. Intention to Participate in a COVID-19 Vaccine Clinical Trial and to Get Vaccinated Against COVID-19 in France During the Pandemic. Vaccine. 2020 10 21;38(45):7002-7006. PubMed PMID: 32988688.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intention to participate in a COVID-19 vaccine clinical trial and to get vaccinated against COVID-19 in France during the pandemic. AU - Detoc,Maëlle, AU - Bruel,Sébastien, AU - Frappe,Paul, AU - Tardy,Bernard, AU - Botelho-Nevers,Elisabeth, AU - Gagneux-Brunon,Amandine, Y1 - 2020/09/17/ PY - 2020/07/06/received PY - 2020/09/07/revised PY - 2020/09/14/accepted PY - 2020/9/30/pubmed PY - 2020/10/23/medline PY - 2020/9/29/entrez KW - COVID-19 KW - Pandemics KW - SARS-CoV-2 KW - Vaccine KW - Vaccine hesitancy SP - 7002 EP - 7006 JF - Vaccine JO - Vaccine VL - 38 IS - 45 N2 - INTRODUCTION: The world is facing the COVID-19 pandemic. The development of a vaccine is challenging. We aimed to determine the proportion of people who intend to get vaccinated against COVID-19 in France or to participate in a vaccine clinical trial. METHODS: We conducted an anonymous on-line survey from the 26th of March to the 20th of April 2020. Primary endpoints were the intention to get vaccinated against COVID-19 if a vaccine was available or participate in a vaccine clinical trial. RESULTS: Three thousand two hundred and fifty nine individuals answered the survey; women accounted for 67.4% of the respondents. According to their statements, 2.512 participants (77.6%, 95% CI 76.2-79%) will certainly or probably agree to get vaccinated against COVID-19. Older age, male gender, fear about COVID-19, being a healthcare worker and individual perceived risk were associated with COVID-19 vaccine acceptance. Vaccine hesitancy was associated with a decrease in COVID-19 vaccine acceptance. One thousand and five hundred and fifty respondents (47.6% 95% CI 45.9-49.3%) will certainly or probably agree to participate in a COVID-19 vaccine clinical trial. Older age, male gender, being a healthcare worker and individual perceived risk were associated with potential acceptance to participate in a COVID-19 vaccine clinical trial. Vaccine hesitancy was associated with refusal for participation in a COVID-19 vaccine clinical trial. CONCLUSIONS: Nearly 75% and 48% of the survey respondents were respectively likely to accept vaccination or participation in a clinical trial against COVID-19. Vaccine hesitancy will be the major barrier to COVID-19 vaccine uptake. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/32988688/Intention_to_participate_in_a_COVID_19_vaccine_clinical_trial_and_to_get_vaccinated_against_COVID_19_in_France_during_the_pandemic_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(20)31201-9 DB - PRIME DP - Unbound Medicine ER -