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Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures.
Int J Mol Sci. 2020 Sep 25; 21(19)IJ

Abstract

A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential-and distinct-roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs.

Authors+Show Affiliations

Department of Chemical Sciences, Federico II Naples University, I-80126 Naples, Italy.Department of Physiology, Faculty of Medicine and Dentistry, University of Valencia-INCLIVA, CIBERER, E-46010 Valencia, Spain.Vall d'Hebron Institut de Recerca, E-08035 Barcelona, Catalunya, Spain. Institute of Molecular Biology and Biophysics of the "Federal Research Center of Fundamental and Translational Medicine", Novosibirsk 630117, Russia.Department of Life and Environmental Sciences, Polytechnical University of Marche, I-60100 Ancona, Italy.Internal Medicine Unit, San Francesco d'Assisi Hospital, I-84020 Oliveto Citra (SA), Italy.Department of Chemical Sciences, Federico II Naples University, I-80126 Naples, Italy.Department of Chemical Sciences, Federico II Naples University, I-80126 Naples, Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32992778

Citation

Pagano, Giovanni, et al. "Aging-Related Disorders and Mitochondrial Dysfunction: a Critical Review for Prospect Mitoprotective Strategies Based On Mitochondrial Nutrient Mixtures." International Journal of Molecular Sciences, vol. 21, no. 19, 2020.
Pagano G, Pallardó FV, Lyakhovich A, et al. Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures. Int J Mol Sci. 2020;21(19).
Pagano, G., Pallardó, F. V., Lyakhovich, A., Tiano, L., Fittipaldi, M. R., Toscanesi, M., & Trifuoggi, M. (2020). Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures. International Journal of Molecular Sciences, 21(19). https://doi.org/10.3390/ijms21197060
Pagano G, et al. Aging-Related Disorders and Mitochondrial Dysfunction: a Critical Review for Prospect Mitoprotective Strategies Based On Mitochondrial Nutrient Mixtures. Int J Mol Sci. 2020 Sep 25;21(19) PubMed PMID: 32992778.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures. AU - Pagano,Giovanni, AU - Pallardó,Federico V, AU - Lyakhovich,Alex, AU - Tiano,Luca, AU - Fittipaldi,Maria Rosa, AU - Toscanesi,Maria, AU - Trifuoggi,Marco, Y1 - 2020/09/25/ PY - 2020/08/28/received PY - 2020/09/20/revised PY - 2020/09/22/accepted PY - 2020/9/30/entrez PY - 2020/10/1/pubmed PY - 2021/3/3/medline KW - aging-related disorders KW - microbiome KW - mitochondria KW - mitochondrial dysfunction KW - mitochondrial nutrients KW - optic neuropathies KW - oxidative stress JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 19 N2 - A number of aging-related disorders (ARD) have been related to oxidative stress (OS) and mitochondrial dysfunction (MDF) in a well-established body of literature. Most studies focused on cardiovascular disorders (CVD), type 2 diabetes (T2D), and neurodegenerative disorders. Counteracting OS and MDF has been envisaged to improve the clinical management of ARD, and major roles have been assigned to three mitochondrial cofactors, also termed mitochondrial nutrients (MNs), i.e., α-lipoic acid (ALA), Coenzyme Q10 (CoQ10), and carnitine (CARN). These cofactors exert essential-and distinct-roles in mitochondrial machineries, along with strong antioxidant properties. Clinical trials have mostly relied on the use of only one MN to ARD-affected patients as, e.g., in the case of CoQ10 in CVD, or of ALA in T2D, possibly with the addition of other antioxidants. Only a few clinical and pre-clinical studies reported on the administration of two MNs, with beneficial outcomes, while no available studies reported on the combined administration of three MNs. Based on the literature also from pre-clinical studies, the present review is to recommend the design of clinical trials based on combinations of the three MNs. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32992778/Aging_Related_Disorders_and_Mitochondrial_Dysfunction:_A_Critical_Review_for_Prospect_Mitoprotective_Strategies_Based_on_Mitochondrial_Nutrient_Mixtures_ L2 - https://www.mdpi.com/resolver?pii=ijms21197060 DB - PRIME DP - Unbound Medicine ER -