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[Validity of antigliadin antibodies in the diagnosis of celiac disease].
Pediatr Med Chir 1986 Sep-Oct; 8(5):605-9PM

Abstract

Antibodies to gliadin, detected by immunofluorescence (IFL-AGA) and ELISA (ELISA-AGA), have been found in 68 of 71 (96%) sera from children with active celiac disease. AGA of IgA class were confined to celiac disease on normal diet and after gluten challenge, as all the antibodies, found in children on gluten free diet (40%) and in control gastroenterological diseases (20%), were of IgG class. Sera from 175 first-degree relatives of our celiacs were also screened for AGA. IFL-AGA were positive in 13 (7%) and ELISA-AGA in 27 cases (15%). Antibodies were of IgA class in 13 relatives (7%). A celiac's asymptomatic sister, selected for jejunal biopsy only on the basis of IgA AGA positivity, showed subtotal villous atrophy. Although AGA cannot replace jejunal biopsy in the diagnosis of celiac disease, they can be regarded as useful tools in the screening of gluten sensitive enteropathy. Moreover, as a positive IgA AGA test is closely related to the active phases of celiac disease, their research can be useful both to evaluate the effect of gluten free diet and to establish when a new biopsy is appropriate after gluten challenge.

Authors

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Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ita

PubMed ID

3299285

Citation

Volta, U, et al. "[Validity of Antigliadin Antibodies in the Diagnosis of Celiac Disease]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 8, no. 5, 1986, pp. 605-9.
Volta U, Lazzari R, Cafaro C, et al. [Validity of antigliadin antibodies in the diagnosis of celiac disease]. Pediatr Med Chir. 1986;8(5):605-9.
Volta, U., Lazzari, R., Cafaro, C., Collina, A., Baldoni, A. M., & Balli, F. (1986). [Validity of antigliadin antibodies in the diagnosis of celiac disease]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 8(5), pp. 605-9.
Volta U, et al. [Validity of Antigliadin Antibodies in the Diagnosis of Celiac Disease]. Pediatr Med Chir. 1986;8(5):605-9. PubMed PMID: 3299285.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Validity of antigliadin antibodies in the diagnosis of celiac disease]. AU - Volta,U, AU - Lazzari,R, AU - Cafaro,C, AU - Collina,A, AU - Baldoni,A M, AU - Balli,F, PY - 1986/9/1/pubmed PY - 1986/9/1/medline PY - 1986/9/1/entrez SP - 605 EP - 9 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 8 IS - 5 N2 - Antibodies to gliadin, detected by immunofluorescence (IFL-AGA) and ELISA (ELISA-AGA), have been found in 68 of 71 (96%) sera from children with active celiac disease. AGA of IgA class were confined to celiac disease on normal diet and after gluten challenge, as all the antibodies, found in children on gluten free diet (40%) and in control gastroenterological diseases (20%), were of IgG class. Sera from 175 first-degree relatives of our celiacs were also screened for AGA. IFL-AGA were positive in 13 (7%) and ELISA-AGA in 27 cases (15%). Antibodies were of IgA class in 13 relatives (7%). A celiac's asymptomatic sister, selected for jejunal biopsy only on the basis of IgA AGA positivity, showed subtotal villous atrophy. Although AGA cannot replace jejunal biopsy in the diagnosis of celiac disease, they can be regarded as useful tools in the screening of gluten sensitive enteropathy. Moreover, as a positive IgA AGA test is closely related to the active phases of celiac disease, their research can be useful both to evaluate the effect of gluten free diet and to establish when a new biopsy is appropriate after gluten challenge. SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/3299285/[Validity_of_antigliadin_antibodies_in_the_diagnosis_of_celiac_disease]_ L2 - http://www.diseaseinfosearch.org/result/1186 DB - PRIME DP - Unbound Medicine ER -