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Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases.
Int J Mol Sci. 2020 Sep 28; 21(19)IJ

Abstract

With aging, the nervous system gradually undergoes degeneration. Increased oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are considered to be common pathophysiological mechanisms of various neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), organophosphate-induced delayed neuropathy (OPIDN), and amyotrophic lateral sclerosis (ALS). Autophagy is a cellular basic metabolic process that degrades the aggregated or misfolded proteins and abnormal organelles in cells. The abnormal regulation of neuronal autophagy is accompanied by the accumulation and deposition of irregular proteins, leading to changes in neuron homeostasis and neurodegeneration. Autophagy exhibits both a protective mechanism and a damage pathway related to programmed cell death. Because of its "double-edged sword", autophagy plays an important role in neurological damage and NDDs including AD, PD, HD, OPIDN, and ALS. Melatonin is a neuroendocrine hormone mainly synthesized in the pineal gland and exhibits a wide range of biological functions, such as sleep control, regulating circadian rhythm, immune enhancement, metabolism regulation, antioxidant, anti-aging, and anti-tumor effects. It can prevent cell death, reduce inflammation, block calcium channels, etc. In this review, we briefly discuss the neuroprotective role of melatonin against various NDDs via regulating autophagy, which could be a new field for future translational research and clinical studies to discover preventive or therapeutic agents for many NDDs.

Authors+Show Affiliations

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USA.Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.Division of Neuroscience & Behavior, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20852, USA.Departments of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.Section of Molecular Pharmacology and Toxicology, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD 20892, USA.Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

32998479

Citation

Luo, Fang, et al. "Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases." International Journal of Molecular Sciences, vol. 21, no. 19, 2020.
Luo F, Sandhu AF, Rungratanawanich W, et al. Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. Int J Mol Sci. 2020;21(19).
Luo, F., Sandhu, A. F., Rungratanawanich, W., Williams, G. E., Akbar, M., Zhou, S., Song, B. J., & Wang, X. (2020). Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. International Journal of Molecular Sciences, 21(19). https://doi.org/10.3390/ijms21197174
Luo F, et al. Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. Int J Mol Sci. 2020 Sep 28;21(19) PubMed PMID: 32998479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases. AU - Luo,Fang, AU - Sandhu,Aaron F, AU - Rungratanawanich,Wiramon, AU - Williams,George E, AU - Akbar,Mohammed, AU - Zhou,Shuanhu, AU - Song,Byoung-Joon, AU - Wang,Xin, Y1 - 2020/09/28/ PY - 2020/08/27/received PY - 2020/09/21/revised PY - 2020/09/22/accepted PY - 2020/10/1/entrez PY - 2020/10/2/pubmed PY - 2021/2/26/medline KW - Alzheimer’s disease KW - Huntington’s disease KW - Parkinson’s disease KW - amyotrophic lateral sclerosis KW - autophagy KW - melatonin KW - neurodegenerative diseases KW - organophosphate-induced delayed neuropathy JF - International journal of molecular sciences JO - Int J Mol Sci VL - 21 IS - 19 N2 - With aging, the nervous system gradually undergoes degeneration. Increased oxidative stress, endoplasmic reticulum stress, mitochondrial dysfunction, and cell death are considered to be common pathophysiological mechanisms of various neurodegenerative diseases (NDDs) such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), organophosphate-induced delayed neuropathy (OPIDN), and amyotrophic lateral sclerosis (ALS). Autophagy is a cellular basic metabolic process that degrades the aggregated or misfolded proteins and abnormal organelles in cells. The abnormal regulation of neuronal autophagy is accompanied by the accumulation and deposition of irregular proteins, leading to changes in neuron homeostasis and neurodegeneration. Autophagy exhibits both a protective mechanism and a damage pathway related to programmed cell death. Because of its "double-edged sword", autophagy plays an important role in neurological damage and NDDs including AD, PD, HD, OPIDN, and ALS. Melatonin is a neuroendocrine hormone mainly synthesized in the pineal gland and exhibits a wide range of biological functions, such as sleep control, regulating circadian rhythm, immune enhancement, metabolism regulation, antioxidant, anti-aging, and anti-tumor effects. It can prevent cell death, reduce inflammation, block calcium channels, etc. In this review, we briefly discuss the neuroprotective role of melatonin against various NDDs via regulating autophagy, which could be a new field for future translational research and clinical studies to discover preventive or therapeutic agents for many NDDs. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/32998479/Melatonin_and_Autophagy_in_Aging_Related_Neurodegenerative_Diseases_ L2 - https://www.mdpi.com/resolver?pii=ijms21197174 DB - PRIME DP - Unbound Medicine ER -