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Diabetic retinopathy after 3 years' treatment with continuous subcutaneous insulin infusion (CSII).
Acta Ophthalmol (Copenh). 1987 Apr; 65(2):185-9.AO

Abstract

Twenty-four insulin-dependent juvenile diabetics with no or minimal background retinopathy were randomly allocated to conventional insulin therapy (CIT) or continuous sc insulin infusion (CSII) administrated by a portable pump. At the present 3 year follow-up, there was one drop-out in the CSII group. Although the metabolic control was significantly better in the CSII patients, both groups improved significantly in metabolic control during the observation period. After 3 years, the HbA lc level was 7.4% +/- 1.2 (+/- SD) in the CSII patients and 8.6% +/- 1.6 in the CIT patients (P less than 0.01). As compared to the status at the beginning of the study, a progression of diabetic retinopathy (criteria: development of more than 2 microaneurysms) was observed in 4 of 11 in the CSII group and in 5 of 12 in the CIT group (P greater than 0.05). None of the patients were seen to develop soft exudates or neovascularisations. This study confirms the impression gained from a previous one-year follow-up of similar progression of retinopathy in patients on CSII and CIT.

Authors

Olsen T
No affiliation info available
Richelsen B
No affiliation info available
Ehlers N
No affiliation info available
Beck-Nielsen H
No affiliation info available

MeSH

AdultBlood GlucoseClinical Trials as TopicDiabetes Mellitus, Type 1Diabetic RetinopathyFemaleFollow-Up StudiesHumansInsulinInsulin Infusion SystemsMaleRandom Allocation

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

3300140

Citation

Olsen, T, et al. "Diabetic Retinopathy After 3 Years' Treatment With Continuous Subcutaneous Insulin Infusion (CSII)." Acta Ophthalmologica, vol. 65, no. 2, 1987, pp. 185-9.
Olsen T, Richelsen B, Ehlers N, et al. Diabetic retinopathy after 3 years' treatment with continuous subcutaneous insulin infusion (CSII). Acta Ophthalmol (Copenh). 1987;65(2):185-9.
Olsen, T., Richelsen, B., Ehlers, N., & Beck-Nielsen, H. (1987). Diabetic retinopathy after 3 years' treatment with continuous subcutaneous insulin infusion (CSII). Acta Ophthalmologica, 65(2), 185-9.
Olsen T, et al. Diabetic Retinopathy After 3 Years' Treatment With Continuous Subcutaneous Insulin Infusion (CSII). Acta Ophthalmol (Copenh). 1987;65(2):185-9. PubMed PMID: 3300140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic retinopathy after 3 years' treatment with continuous subcutaneous insulin infusion (CSII). AU - Olsen,T, AU - Richelsen,B, AU - Ehlers,N, AU - Beck-Nielsen,H, PY - 1987/4/1/pubmed PY - 1987/4/1/medline PY - 1987/4/1/entrez SP - 185 EP - 9 JF - Acta ophthalmologica JO - Acta Ophthalmol (Copenh) VL - 65 IS - 2 N2 - Twenty-four insulin-dependent juvenile diabetics with no or minimal background retinopathy were randomly allocated to conventional insulin therapy (CIT) or continuous sc insulin infusion (CSII) administrated by a portable pump. At the present 3 year follow-up, there was one drop-out in the CSII group. Although the metabolic control was significantly better in the CSII patients, both groups improved significantly in metabolic control during the observation period. After 3 years, the HbA lc level was 7.4% +/- 1.2 (+/- SD) in the CSII patients and 8.6% +/- 1.6 in the CIT patients (P less than 0.01). As compared to the status at the beginning of the study, a progression of diabetic retinopathy (criteria: development of more than 2 microaneurysms) was observed in 4 of 11 in the CSII group and in 5 of 12 in the CIT group (P greater than 0.05). None of the patients were seen to develop soft exudates or neovascularisations. This study confirms the impression gained from a previous one-year follow-up of similar progression of retinopathy in patients on CSII and CIT. SN - 0001-639X UR - https://www.unboundmedicine.com/medline/citation/3300140/Diabetic_retinopathy_after_3_years'_treatment_with_continuous_subcutaneous_insulin_infusion__CSII__ DB - PRIME DP - Unbound Medicine ER -