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Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis.
Pharmacol Res. 2020 11; 161:105210.PR

Abstract

BACKGROUND

Oxidative stress, defined as an imbalance between pro-oxidants and neutralizing antioxidants within the body, is a growing public health concern. Oxidative stress is involved in the progression of nearly all chronic diseases. Melatonin has been suggested to reduce oxidative stress by its potential radical scavenging properties.

OBJECTIVE

To determine the efficacy and safety of melatonin as a therapy for the improvement of oxidative stress parameters in randomized controlled trials.

METHODS

A systematic database search using Scopus, PubMed/Medline, EMBASE, Web of Science, the Cochrane Controlled Register of Trials and clinicaltrials.gov (https://clinicaltrials.gov) for studies published up to July 2020 was conducted. We included studies which investigated the effect of supplemental melatonin compared to placebo on oxidative stress parameters in unhealthy patients. Quantitative data synthesis was conducted using a random-effects model with standard mean difference (SMD) and 95 % confidence intervals (CI). Cochrane's Q and I2 values were used to evaluate heterogeneity.

RESULTS

A total of 12 randomized controlled trials (RCTs) were eligible. The meta-analysis indicated an association between melatonin intake and a significant increase in total antioxidant capacity (TAC) (SMD: 0.76; 95 % CI: 0.30, 1.21; I2 = 80.1 %), glutathione (GSH) levels (SMD: 0.57; 95 % CI: 0.32, 0.83; I2 = 15.1 %), superoxide dismutase (SOD) (SMD: 1.38; 95 % CI: 0.13, 2.62; I2 = 86.9 %), glutathione peroxidase (GPx) (SMD: 1.36; 95 % CI: 0.46, 2.30; I2 = 89.3 %), glutathione reductase (GR) (SMD: 1.21; 95 % CI: 0.65, 1.77; I2 = 00.0 %) activities, and a significant reduction in malondialdehyde (MDA) levels (SMD: -0.79; 95 % CI: -1.19, -0.39; I2 = 73.1 %). Melatonin intake was not shown to significantly affect nitric oxide (NO) levels (SMD: -0.24; 95 % CI: -0.61, 0.14; I2 = 00.0 %) or catalase (CAT) activity (SMD: -1.38; 95 % CI: -1.42, 4.18; I2 = 96.6 %).

CONCLUSION

Melatonin intake was shown to have a significant impact on improving Oxidative stress parameters. However, future research through large, well-designed randomized controlled trials are required to determine the effect of melatonin on oxidative stress parameters in different age groups and different disease types.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Morvaridzadeh M
Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Sadeghi E
Research Center for Environmental Determinants of Health (RCEDH), Research Institute for Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: ehsan.sadeghi59@yahoo.com.
Agah S
Colorectal Research Center, Iran University of Medical Sciences, Tehran, Iran.
Nachvak SM
Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Fazelian S
Clinical Research Development Unit, Ayatollah Kashani Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Moradi F
Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Persad E
Department for Evidence-based Medicine and Evaluation, Danube University Krems, Krems, Austria.
Heshmati J
Department of Nutritional Science, School of Nutritional Science and Food Technology, Kermanshah University of Medical Sciences, Kermanshah, Iran. Electronic address: Javad.Heshmati@gmail.com.

MeSH

AdolescentAdultAgedAntioxidantsBiomarkersCatalaseChildDietary SupplementsFemaleGlutathioneGlutathione PeroxidaseGlutathione ReductaseHumansLipid PeroxidationMaleMalondialdehydeMelatoninMiddle AgedNitric OxideOxidative StressRandomized Controlled Trials as TopicSuperoxide DismutaseTreatment OutcomeYoung Adult

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33007423

Citation

Morvaridzadeh, Mojgan, et al. "Effect of Melatonin Supplementation On Oxidative Stress Parameters: a Systematic Review and Meta-analysis." Pharmacological Research, vol. 161, 2020, p. 105210.
Morvaridzadeh M, Sadeghi E, Agah S, et al. Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis. Pharmacol Res. 2020;161:105210.
Morvaridzadeh, M., Sadeghi, E., Agah, S., Nachvak, S. M., Fazelian, S., Moradi, F., Persad, E., & Heshmati, J. (2020). Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis. Pharmacological Research, 161, 105210. https://doi.org/10.1016/j.phrs.2020.105210
Morvaridzadeh M, et al. Effect of Melatonin Supplementation On Oxidative Stress Parameters: a Systematic Review and Meta-analysis. Pharmacol Res. 2020;161:105210. PubMed PMID: 33007423.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of melatonin supplementation on oxidative stress parameters: A systematic review and meta-analysis. AU - Morvaridzadeh,Mojgan, AU - Sadeghi,Ehsan, AU - Agah,Shahram, AU - Nachvak,Seyed Mostafa, AU - Fazelian,Siavash, AU - Moradi,Fatemeh, AU - Persad,Emma, AU - Heshmati,Javad, Y1 - 2020/09/29/ PY - 2020/08/04/received PY - 2020/09/11/revised PY - 2020/09/15/accepted PY - 2020/10/3/pubmed PY - 2021/9/2/medline PY - 2020/10/2/entrez KW - Glutathione KW - Malondialdehyde KW - Melatonin KW - Oxidative stress KW - Total antioxidant capacity SP - 105210 EP - 105210 JF - Pharmacological research JO - Pharmacol Res VL - 161 N2 - BACKGROUND: Oxidative stress, defined as an imbalance between pro-oxidants and neutralizing antioxidants within the body, is a growing public health concern. Oxidative stress is involved in the progression of nearly all chronic diseases. Melatonin has been suggested to reduce oxidative stress by its potential radical scavenging properties. OBJECTIVE: To determine the efficacy and safety of melatonin as a therapy for the improvement of oxidative stress parameters in randomized controlled trials. METHODS: A systematic database search using Scopus, PubMed/Medline, EMBASE, Web of Science, the Cochrane Controlled Register of Trials and clinicaltrials.gov (https://clinicaltrials.gov) for studies published up to July 2020 was conducted. We included studies which investigated the effect of supplemental melatonin compared to placebo on oxidative stress parameters in unhealthy patients. Quantitative data synthesis was conducted using a random-effects model with standard mean difference (SMD) and 95 % confidence intervals (CI). Cochrane's Q and I2 values were used to evaluate heterogeneity. RESULTS: A total of 12 randomized controlled trials (RCTs) were eligible. The meta-analysis indicated an association between melatonin intake and a significant increase in total antioxidant capacity (TAC) (SMD: 0.76; 95 % CI: 0.30, 1.21; I2 = 80.1 %), glutathione (GSH) levels (SMD: 0.57; 95 % CI: 0.32, 0.83; I2 = 15.1 %), superoxide dismutase (SOD) (SMD: 1.38; 95 % CI: 0.13, 2.62; I2 = 86.9 %), glutathione peroxidase (GPx) (SMD: 1.36; 95 % CI: 0.46, 2.30; I2 = 89.3 %), glutathione reductase (GR) (SMD: 1.21; 95 % CI: 0.65, 1.77; I2 = 00.0 %) activities, and a significant reduction in malondialdehyde (MDA) levels (SMD: -0.79; 95 % CI: -1.19, -0.39; I2 = 73.1 %). Melatonin intake was not shown to significantly affect nitric oxide (NO) levels (SMD: -0.24; 95 % CI: -0.61, 0.14; I2 = 00.0 %) or catalase (CAT) activity (SMD: -1.38; 95 % CI: -1.42, 4.18; I2 = 96.6 %). CONCLUSION: Melatonin intake was shown to have a significant impact on improving Oxidative stress parameters. However, future research through large, well-designed randomized controlled trials are required to determine the effect of melatonin on oxidative stress parameters in different age groups and different disease types. SN - 1096-1186 UR - https://www.unboundmedicine.com/medline/citation/33007423/Effect_of_melatonin_supplementation_on_oxidative_stress_parameters:_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -