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Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus.
Plant Foods Hum Nutr. 2020 Dec; 75(4):621-627.PF

Abstract

Advanced glycation end-products (AGEs) may be a contributing factor in the development of diabetes-specific vascular pathologies that affect the retina, glomerulus and peripheral nerves. In this study, Australian native food plant species Syzygium paniculatum was investigated for activities relevant to Type 2 diabetes mellitus including inhibition of α-amylase, α-glucosidase and protein glycation. A methanolic extract of the leaves showed the strongest α-amylase inhibition (IC50 = 14.29 ± 0.82 μg/mL, p < 0.05) when compared with other extracts. For inhibition of α-glucosidase, the strongest inhibition was shown for the water, methanolic and acetone extracts of leaves with IC50 values ranging from 4.73 ± 0.96 to 7.26 ± 0.92 μg/mL. In the BSA-glucose model, fruit and leaf extracts inhibited formation of protein-bound fluorescent AGEs with IC50 values ranging between 11.82 ± 0.71 and 96.80 ± 13.41 μg/mL. Pearson's correlation analysis showed that the AGE inhibition significantly correlated with DPPH (rp = -0.8964, p < 0.05) and ABTS (rp = -0.8326, p < 0.05). α-amylase inhibitory activities strongly correlated with DPPH (rp = -0.8964, p < 0.001). α-glucosidase inhibition strongly correlated with TPC (rp = -0.9243, p < 0.05), FRAP (rp = -0.9502, p < 0.01), DPPH (rp = -0.9317, p < 0.01) and ABTS (rp = -0.9486, p < 0.01). This study provides a strong rationale for further investigation aimed at isolating and identifying the active compounds responsible for the observed effects on targets relevant to diabetes.

Authors+Show Affiliations

Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.Quality Use of Medicines and Pharmacy Research Centre, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia.Health and Biomedical Innovation, Clinical and Health Sciences, University of South Australia, Adelaide, South Australia, 5000, Australia. Permal.Deo@unisa.edu.au.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33009631

Citation

Kim, Sangseo, et al. "Antioxidant and Antiglycation Activities of Syzygium Paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus." Plant Foods for Human Nutrition (Dordrecht, Netherlands), vol. 75, no. 4, 2020, pp. 621-627.
Kim S, Semple SJ, Simpson BS, et al. Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus. Plant Foods Hum Nutr. 2020;75(4):621-627.
Kim, S., Semple, S. J., Simpson, B. S., & Deo, P. (2020). Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus. Plant Foods for Human Nutrition (Dordrecht, Netherlands), 75(4), 621-627. https://doi.org/10.1007/s11130-020-00858-4
Kim S, et al. Antioxidant and Antiglycation Activities of Syzygium Paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus. Plant Foods Hum Nutr. 2020;75(4):621-627. PubMed PMID: 33009631.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and Antiglycation Activities of Syzygium paniculatum Gaertn and Inhibition of Digestive Enzymes Relevant to Type 2 Diabetes Mellitus. AU - Kim,Sangseo, AU - Semple,Susan J, AU - Simpson,Bradley S, AU - Deo,Permal, Y1 - 2020/10/03/ PY - 2020/09/22/accepted PY - 2020/10/4/pubmed PY - 2020/11/25/medline PY - 2020/10/3/entrez KW - Advanced glycation end-products KW - Antiglycation KW - Antioxidant activities KW - Syzygium paniculatum KW - α-Amylase KW - α-Glucosidase SP - 621 EP - 627 JF - Plant foods for human nutrition (Dordrecht, Netherlands) JO - Plant Foods Hum Nutr VL - 75 IS - 4 N2 - Advanced glycation end-products (AGEs) may be a contributing factor in the development of diabetes-specific vascular pathologies that affect the retina, glomerulus and peripheral nerves. In this study, Australian native food plant species Syzygium paniculatum was investigated for activities relevant to Type 2 diabetes mellitus including inhibition of α-amylase, α-glucosidase and protein glycation. A methanolic extract of the leaves showed the strongest α-amylase inhibition (IC50 = 14.29 ± 0.82 μg/mL, p < 0.05) when compared with other extracts. For inhibition of α-glucosidase, the strongest inhibition was shown for the water, methanolic and acetone extracts of leaves with IC50 values ranging from 4.73 ± 0.96 to 7.26 ± 0.92 μg/mL. In the BSA-glucose model, fruit and leaf extracts inhibited formation of protein-bound fluorescent AGEs with IC50 values ranging between 11.82 ± 0.71 and 96.80 ± 13.41 μg/mL. Pearson's correlation analysis showed that the AGE inhibition significantly correlated with DPPH (rp = -0.8964, p < 0.05) and ABTS (rp = -0.8326, p < 0.05). α-amylase inhibitory activities strongly correlated with DPPH (rp = -0.8964, p < 0.001). α-glucosidase inhibition strongly correlated with TPC (rp = -0.9243, p < 0.05), FRAP (rp = -0.9502, p < 0.01), DPPH (rp = -0.9317, p < 0.01) and ABTS (rp = -0.9486, p < 0.01). This study provides a strong rationale for further investigation aimed at isolating and identifying the active compounds responsible for the observed effects on targets relevant to diabetes. SN - 1573-9104 UR - https://www.unboundmedicine.com/medline/citation/33009631/Antioxidant_and_Antiglycation_Activities_of_Syzygium_paniculatum_Gaertn_and_Inhibition_of_Digestive_Enzymes_Relevant_to_Type_2_Diabetes_Mellitus_ L2 - https://doi.org/10.1007/s11130-020-00858-4 DB - PRIME DP - Unbound Medicine ER -