Citation
Rydyznski Moderbacher, Carolyn, et al. "Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations With Age and Disease Severity." Cell, vol. 183, no. 4, 2020, pp. 996-1012.e19.
Rydyznski Moderbacher C, Ramirez SI, Dan JM, et al. Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity. Cell. 2020;183(4):996-1012.e19.
Rydyznski Moderbacher, C., Ramirez, S. I., Dan, J. M., Grifoni, A., Hastie, K. M., Weiskopf, D., Belanger, S., Abbott, R. K., Kim, C., Choi, J., Kato, Y., Crotty, E. G., Kim, C., Rawlings, S. A., Mateus, J., Tse, L. P. V., Frazier, A., Baric, R., Peters, B., ... Crotty, S. (2020). Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity. Cell, 183(4), 996-e19. https://doi.org/10.1016/j.cell.2020.09.038
Rydyznski Moderbacher C, et al. Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations With Age and Disease Severity. Cell. 2020 11 12;183(4):996-1012.e19. PubMed PMID: 33010815.
TY - JOUR
T1 - Antigen-Specific Adaptive Immunity to SARS-CoV-2 in Acute COVID-19 and Associations with Age and Disease Severity.
AU - Rydyznski Moderbacher,Carolyn,
AU - Ramirez,Sydney I,
AU - Dan,Jennifer M,
AU - Grifoni,Alba,
AU - Hastie,Kathryn M,
AU - Weiskopf,Daniela,
AU - Belanger,Simon,
AU - Abbott,Robert K,
AU - Kim,Christina,
AU - Choi,Jinyong,
AU - Kato,Yu,
AU - Crotty,Eleanor G,
AU - Kim,Cheryl,
AU - Rawlings,Stephen A,
AU - Mateus,Jose,
AU - Tse,Long Ping Victor,
AU - Frazier,April,
AU - Baric,Ralph,
AU - Peters,Bjoern,
AU - Greenbaum,Jason,
AU - Ollmann Saphire,Erica,
AU - Smith,Davey M,
AU - Sette,Alessandro,
AU - Crotty,Shane,
Y1 - 2020/09/16/
PY - 2020/08/06/received
PY - 2020/08/21/revised
PY - 2020/09/11/accepted
PY - 2020/10/5/pubmed
PY - 2020/11/26/medline
PY - 2020/10/4/entrez
KW - CD4
KW - CD8
KW - CXCL10
KW - IP-10
KW - Spike
KW - T cells
KW - adaptive immunity
KW - antibody
KW - coronavirus
KW - epitopes
KW - neutralizing antibodies
SP - 996
EP - 1012.e19
JF - Cell
JO - Cell
VL - 183
IS - 4
N2 - Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+ and CD8+ T cell and neutralizing antibody responses in acute and convalescent subjects. SARS-CoV-2-specific CD4+ and CD8+ T cells were each associated with milder disease. Coordinated SARS-CoV-2-specific adaptive immune responses were associated with milder disease, suggesting roles for both CD4+ and CD8+ T cells in protective immunity in COVID-19. Notably, coordination of SARS-CoV-2 antigen-specific responses was disrupted in individuals ≥ 65 years old. Scarcity of naive T cells was also associated with aging and poor disease outcomes. A parsimonious explanation is that coordinated CD4+ T cell, CD8+ T cell, and antibody responses are protective, but uncoordinated responses frequently fail to control disease, with a connection between aging and impaired adaptive immune responses to SARS-CoV-2.
SN - 1097-4172
UR - https://www.unboundmedicine.com/medline/citation/33010815/Antigen_Specific_Adaptive_Immunity_to_SARS_CoV_2_in_Acute_COVID_19_and_Associations_with_Age_and_Disease_Severity_
L2 - https://linkinghub.elsevier.com/retrieve/pii/S0092-8674(20)31235-6
DB - PRIME
DP - Unbound Medicine
ER -