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Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
JACC Basic Transl Sci. 2020 Sep; 5(9):888-897.JB

Abstract

Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.

Authors+Show Affiliations

Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Centre de Recherche du CHU de Québec, Quebec, Canada.Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.Robarts Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Surgery, Faculty of Medicine, Université Laval, Québec, Canada.Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Québec, Quebec, Canada. Department of Medicine, Faculty of Medicine, Université Laval, Québec, Canada.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33015412

Citation

Bourgeois, Raphaëlle, et al. "Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis." JACC. Basic to Translational Science, vol. 5, no. 9, 2020, pp. 888-897.
Bourgeois R, Devillers R, Perrot N, et al. Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2020;5(9):888-897.
Bourgeois, R., Devillers, R., Perrot, N., Després, A. A., Boulanger, M. C., Mitchell, P. L., Guertin, J., Couture, P., Boffa, M. B., Scipione, C. A., Pibarot, P., Koschinsky, M. L., Mathieu, P., & Arsenault, B. J. (2020). Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis. JACC. Basic to Translational Science, 5(9), 888-897. https://doi.org/10.1016/j.jacbts.2020.06.012
Bourgeois R, et al. Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis. JACC Basic Transl Sci. 2020;5(9):888-897. PubMed PMID: 33015412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis. AU - Bourgeois,Raphaëlle, AU - Devillers,Romain, AU - Perrot,Nicolas, AU - Després,Audrey-Anne, AU - Boulanger,Marie-Chloé, AU - Mitchell,Patricia L, AU - Guertin,Jakie, AU - Couture,Patrick, AU - Boffa,Michael B, AU - Scipione,Corey A, AU - Pibarot,Philippe, AU - Koschinsky,Marlys L, AU - Mathieu,Patrick, AU - Arsenault,Benoit J, Y1 - 2020/08/26/ PY - 2020/03/20/received PY - 2020/06/22/revised PY - 2020/06/23/accepted PY - 2020/10/5/entrez PY - 2020/10/6/pubmed PY - 2020/10/6/medline KW - ALR, adiponectin-to-leptin ratio KW - ATX, autotaxin KW - ATX-apo(a), ATX carried by Lp(a) KW - ATX-apoB, ATX carried by apoB-containing lipoproteins KW - BMI, body mass index KW - CAD, coronary artery disease KW - CAVS, calcific aortic valve stenosis KW - HDL, high-density lipoprotein KW - LDL, low-density lipoprotein KW - Lp(a), lipoprotein(a) KW - LysoPA, lysophosphatidic acid KW - LysoPC, lysophosphatidylcholine KW - OxPLs, oxidized phospholipids KW - apo(a), apolipoprotein(a) KW - apoB, apolipoprotein B KW - autotaxin KW - calcific aortic valve stenosis KW - lipoprotein(a) KW - low-density lipoproteins KW - obesity SP - 888 EP - 897 JF - JACC. Basic to translational science JO - JACC Basic Transl Sci VL - 5 IS - 9 N2 - Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS. SN - 2452-302X UR - https://www.unboundmedicine.com/medline/citation/33015412/Interaction_of_Autotaxin_With_Lipoprotein_a__in_Patients_With_Calcific_Aortic_Valve_Stenosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2452-302X(20)30303-X DB - PRIME DP - Unbound Medicine ER -