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Cisapride: influence on oesophageal and gastric emptying and gastro-oesophageal reflux in patients with reflux oesophagitis.
Hepatogastroenterology 1987; 34(3):113-6H

Abstract

A preliminary, double-blind placebo controlled trial of cisapride in reflux oesophagitis was conducted. Eighteen patients were allocated to treatment with either placebo or cisapride, 10 mg three times daily, orally, before meals. Gastric emptying of a scrambled egg meal, oesophageal transit of a liquid bolus and ambulatory monitoring of oesophageal pH were assessed before and after four weeks' therapy. Overall, gastric emptying rates were not influenced by cisapride, although a small but significant reduction in gastric isotope retention, 20 minutes after meal ingestion was observed in patients on the active drug. Oesophageal transit times were not altered by cisapride. A small but significant reduction in the duration of gastro-oesophageal reflux followed cisapride therapy when compared with placebo.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3301606

Citation

Collins, B J., et al. "Cisapride: Influence On Oesophageal and Gastric Emptying and Gastro-oesophageal Reflux in Patients With Reflux Oesophagitis." Hepato-gastroenterology, vol. 34, no. 3, 1987, pp. 113-6.
Collins BJ, Spence RA, Ferguson R, et al. Cisapride: influence on oesophageal and gastric emptying and gastro-oesophageal reflux in patients with reflux oesophagitis. Hepatogastroenterology. 1987;34(3):113-6.
Collins, B. J., Spence, R. A., Ferguson, R., Laird, J., & Love, A. H. (1987). Cisapride: influence on oesophageal and gastric emptying and gastro-oesophageal reflux in patients with reflux oesophagitis. Hepato-gastroenterology, 34(3), pp. 113-6.
Collins BJ, et al. Cisapride: Influence On Oesophageal and Gastric Emptying and Gastro-oesophageal Reflux in Patients With Reflux Oesophagitis. Hepatogastroenterology. 1987;34(3):113-6. PubMed PMID: 3301606.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cisapride: influence on oesophageal and gastric emptying and gastro-oesophageal reflux in patients with reflux oesophagitis. AU - Collins,B J, AU - Spence,R A, AU - Ferguson,R, AU - Laird,J, AU - Love,A H, PY - 1987/6/1/pubmed PY - 1987/6/1/medline PY - 1987/6/1/entrez SP - 113 EP - 6 JF - Hepato-gastroenterology JO - Hepatogastroenterology VL - 34 IS - 3 N2 - A preliminary, double-blind placebo controlled trial of cisapride in reflux oesophagitis was conducted. Eighteen patients were allocated to treatment with either placebo or cisapride, 10 mg three times daily, orally, before meals. Gastric emptying of a scrambled egg meal, oesophageal transit of a liquid bolus and ambulatory monitoring of oesophageal pH were assessed before and after four weeks' therapy. Overall, gastric emptying rates were not influenced by cisapride, although a small but significant reduction in gastric isotope retention, 20 minutes after meal ingestion was observed in patients on the active drug. Oesophageal transit times were not altered by cisapride. A small but significant reduction in the duration of gastro-oesophageal reflux followed cisapride therapy when compared with placebo. SN - 0172-6390 UR - https://www.unboundmedicine.com/medline/citation/3301606/Cisapride:_influence_on_oesophageal_and_gastric_emptying_and_gastro_oesophageal_reflux_in_patients_with_reflux_oesophagitis_ L2 - https://medlineplus.gov/gerd.html DB - PRIME DP - Unbound Medicine ER -