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The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials.
Crit Rev Food Sci Nutr. 2022; 62(2):490-507.CR

Abstract

BACKGROUND AND AIMS

During the last decades, there has been a burst of scientific literature hypothesizing the antioxidant effect of probiotics. However, the results of these studies are inconsistent and a final conclusion has yet to be reached. Thus, the aim of this study was to assess the effects of probiotic/synbiotic supplementation on serum total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels in adults.

METHODS AND RESULTS

The following online databases were searched until August 26th 2020: PubMed/Medline, Scopus, Clarivate Analytics Web of Science, Cochrane Central Register of Controlled Trials, Science Direct, Google Scholar and Igaku Chuo Zasshi. The effect sizes were expressed as the weighted mean difference (WMD) with 95% confidence intervals (CI). A total of 31 eligible trials with 1681 participants (839 cases and 842 controls) were included in this meta-analysis. The results revealed that the supplementation with probiotics/synbiotics, significantly increased serum TAC (WMD: 54.14 mmol/L, 95% CI: 27.87, 80.40, P < 0.001), GSH (WMD: 40.38 μmol/L, 95% CI: 20.72, 60.03, P < 0.001) and NO (WMD: 3.54 μmol/L, 95% CI: 1.73, 5.34, P < 0.001) levels. In addition, MDA levels were significantly reduced (WMD: -0.45 μmol/L, 95% CI: -0.58,-0.32, P < 0.001) following probiotic/synbiotic supplementation. None of the variables showed a significant change in the sensitivity analysis.

CONCLUSION

Available evidence suggests that probiotic/synbiotic supplementation can significantly increase serum TAC, GSH and NO, as well as reduce MDA levels in adults. Therefore, probiotic/synbiotic supplementation may play a role in improving antioxidant indices and reducing oxidative stress in the body.

Authors+Show Affiliations

Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran Iran. Student Research Committee, Faculty of public health branch, Iran University of Medical Sciences, Tehran Iran.Student Research Committee, Faculty of public health branch, Iran University of Medical Sciences, Tehran Iran.Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran Iran. Student Research Committee, Faculty of public health branch, Iran University of Medical Sciences, Tehran Iran.Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania.Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

33016089

Citation

Pourrajab, Behnaz, et al. "The Effects of Probiotic/synbiotic Supplementation Compared to Placebo On Biomarkers of Oxidative Stress in Adults: a Systematic Review and Meta-analysis of Randomized Controlled Trials." Critical Reviews in Food Science and Nutrition, vol. 62, no. 2, 2022, pp. 490-507.
Pourrajab B, Fatahi S, Sohouli MH, et al. The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2022;62(2):490-507.
Pourrajab, B., Fatahi, S., Sohouli, M. H., Găman, M. A., & Shidfar, F. (2022). The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. Critical Reviews in Food Science and Nutrition, 62(2), 490-507. https://doi.org/10.1080/10408398.2020.1821166
Pourrajab B, et al. The Effects of Probiotic/synbiotic Supplementation Compared to Placebo On Biomarkers of Oxidative Stress in Adults: a Systematic Review and Meta-analysis of Randomized Controlled Trials. Crit Rev Food Sci Nutr. 2022;62(2):490-507. PubMed PMID: 33016089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of probiotic/synbiotic supplementation compared to placebo on biomarkers of oxidative stress in adults: a systematic review and meta-analysis of randomized controlled trials. AU - Pourrajab,Behnaz, AU - Fatahi,Somaye, AU - Sohouli,Mohammad Hassan, AU - Găman,Mihnea-Alexandru, AU - Shidfar,Farzad, Y1 - 2020/10/04/ PY - 2020/10/6/pubmed PY - 2022/1/1/medline PY - 2020/10/5/entrez KW - GSH KW - MDA KW - NO KW - Probiotic KW - TAC KW - meta-analysis KW - oxidative stress KW - synbiotic KW - systematic review SP - 490 EP - 507 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 62 IS - 2 N2 - BACKGROUND AND AIMS: During the last decades, there has been a burst of scientific literature hypothesizing the antioxidant effect of probiotics. However, the results of these studies are inconsistent and a final conclusion has yet to be reached. Thus, the aim of this study was to assess the effects of probiotic/synbiotic supplementation on serum total antioxidant capacity (TAC), glutathione (GSH), malondialdehyde (MDA) and nitric oxide (NO) levels in adults. METHODS AND RESULTS: The following online databases were searched until August 26th 2020: PubMed/Medline, Scopus, Clarivate Analytics Web of Science, Cochrane Central Register of Controlled Trials, Science Direct, Google Scholar and Igaku Chuo Zasshi. The effect sizes were expressed as the weighted mean difference (WMD) with 95% confidence intervals (CI). A total of 31 eligible trials with 1681 participants (839 cases and 842 controls) were included in this meta-analysis. The results revealed that the supplementation with probiotics/synbiotics, significantly increased serum TAC (WMD: 54.14 mmol/L, 95% CI: 27.87, 80.40, P < 0.001), GSH (WMD: 40.38 μmol/L, 95% CI: 20.72, 60.03, P < 0.001) and NO (WMD: 3.54 μmol/L, 95% CI: 1.73, 5.34, P < 0.001) levels. In addition, MDA levels were significantly reduced (WMD: -0.45 μmol/L, 95% CI: -0.58,-0.32, P < 0.001) following probiotic/synbiotic supplementation. None of the variables showed a significant change in the sensitivity analysis. CONCLUSION: Available evidence suggests that probiotic/synbiotic supplementation can significantly increase serum TAC, GSH and NO, as well as reduce MDA levels in adults. Therefore, probiotic/synbiotic supplementation may play a role in improving antioxidant indices and reducing oxidative stress in the body. SN - 1549-7852 UR - https://www.unboundmedicine.com/medline/citation/33016089/The_effects_of_probiotic/synbiotic_supplementation_compared_to_placebo_on_biomarkers_of_oxidative_stress_in_adults:_a_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ DB - PRIME DP - Unbound Medicine ER -