Tags

Type your tag names separated by a space and hit enter

Pre-plasticization of thermal binder facilitates processing and granule growth during melt granulation of gabapentin using co-rotating twin screw extruder.
Drug Dev Ind Pharm. 2020 Dec; 46(12):1971-1978.DD

Abstract

Plasticization, a common method of reducing the polymer melt viscosity in plastics extrusion, was investigated to improve the processability of a pharmaceutical formulation during twin-screw melt granulation. The thermolabile drug gabapentin was used as a model compound given previous work showed the benefit of preparing 80% drug loading gabapentin granules with hydroxypropyl cellulose as thermal binder. The plasticizer triethyl citrate was selected based on physicochemical compatibility with both the thermal binder and gabapentin by assessing polymer melt rheology and drug stability, respectively. Gabapentin was melt granulated at 80% drug loading with pre-plasticized binder using a co-rotating twin-screw extruder. The chemical stability and tabletability of the pre-plasticized granules were assessed to evaluate granule tabletability, drug stability, and process robustness. The granulation of gabapentin was facilitated by pre-plasticization, showing both increased granule growth and the ability to optimize processing conditions by lowering processing temperature. Pre-plasticization of thermal binder was therefore shown to be beneficial during melt granulation as a method of optimizing processing conditions while maintaining granule robustness.

Authors+Show Affiliations

The University of Texas at Austin College of Pharmacy, Austin, TX, USA.The University of Texas at Austin College of Pharmacy, Austin, TX, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33016148

Citation

Spahn, Jamie E., and Feng Zhang. "Pre-plasticization of Thermal Binder Facilitates Processing and Granule Growth During Melt Granulation of Gabapentin Using Co-rotating Twin Screw Extruder." Drug Development and Industrial Pharmacy, vol. 46, no. 12, 2020, pp. 1971-1978.
Spahn JE, Zhang F. Pre-plasticization of thermal binder facilitates processing and granule growth during melt granulation of gabapentin using co-rotating twin screw extruder. Drug Dev Ind Pharm. 2020;46(12):1971-1978.
Spahn, J. E., & Zhang, F. (2020). Pre-plasticization of thermal binder facilitates processing and granule growth during melt granulation of gabapentin using co-rotating twin screw extruder. Drug Development and Industrial Pharmacy, 46(12), 1971-1978. https://doi.org/10.1080/03639045.2020.1831014
Spahn JE, Zhang F. Pre-plasticization of Thermal Binder Facilitates Processing and Granule Growth During Melt Granulation of Gabapentin Using Co-rotating Twin Screw Extruder. Drug Dev Ind Pharm. 2020;46(12):1971-1978. PubMed PMID: 33016148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre-plasticization of thermal binder facilitates processing and granule growth during melt granulation of gabapentin using co-rotating twin screw extruder. AU - Spahn,Jamie E, AU - Zhang,Feng, Y1 - 2020/10/22/ PY - 2020/10/6/pubmed PY - 2021/3/20/medline PY - 2020/10/5/entrez KW - Twin-screw extruder KW - degradation KW - gabapentin KW - melt granulation KW - plasticizer KW - processing KW - rheology KW - thermal binder SP - 1971 EP - 1978 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 46 IS - 12 N2 - Plasticization, a common method of reducing the polymer melt viscosity in plastics extrusion, was investigated to improve the processability of a pharmaceutical formulation during twin-screw melt granulation. The thermolabile drug gabapentin was used as a model compound given previous work showed the benefit of preparing 80% drug loading gabapentin granules with hydroxypropyl cellulose as thermal binder. The plasticizer triethyl citrate was selected based on physicochemical compatibility with both the thermal binder and gabapentin by assessing polymer melt rheology and drug stability, respectively. Gabapentin was melt granulated at 80% drug loading with pre-plasticized binder using a co-rotating twin-screw extruder. The chemical stability and tabletability of the pre-plasticized granules were assessed to evaluate granule tabletability, drug stability, and process robustness. The granulation of gabapentin was facilitated by pre-plasticization, showing both increased granule growth and the ability to optimize processing conditions by lowering processing temperature. Pre-plasticization of thermal binder was therefore shown to be beneficial during melt granulation as a method of optimizing processing conditions while maintaining granule robustness. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/33016148/Pre_plasticization_of_thermal_binder_facilitates_processing_and_granule_growth_during_melt_granulation_of_gabapentin_using_co_rotating_twin_screw_extruder_ L2 - https://www.tandfonline.com/doi/full/10.1080/03639045.2020.1831014 DB - PRIME DP - Unbound Medicine ER -