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Diabetic photoreceptors: Mechanisms underlying changes in structure and function.
Vis Neurosci. 2020 10 06; 37:E008.VN

Abstract

Based on clinical findings, diabetic retinopathy (DR) has traditionally been defined as a retinal microvasculopathy. Retinal neuronal dysfunction is now recognized as an early event in the diabetic retina before development of overt DR. While detrimental effects of diabetes on the survival and function of inner retinal cells, such as retinal ganglion cells and amacrine cells, are widely recognized, evidence that photoreceptors in the outer retina undergo early alterations in diabetes has emerged more recently. We review data from preclinical and clinical studies demonstrating a conserved reduction of electrophysiological function in diabetic retinas, as well as evidence for photoreceptor loss. Complementing in vivo studies, we discuss the ex vivo electroretinography technique as a useful method to investigate photoreceptor function in isolated retinas from diabetic animal models. Finally, we consider the possibility that early photoreceptor pathology contributes to the progression of DR, and discuss possible mechanisms of photoreceptor damage in the diabetic retina, such as enhanced production of reactive oxygen species and other inflammatory factors whose detrimental effects may be augmented by phototransduction.

Authors+Show Affiliations

John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.John A. Moran Eye Center, University of Utah, Salt Lake City, Utah.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

33019947

Citation

Becker, Silke, et al. "Diabetic Photoreceptors: Mechanisms Underlying Changes in Structure and Function." Visual Neuroscience, vol. 37, 2020, pp. E008.
Becker S, Carroll LS, Vinberg F. Diabetic photoreceptors: Mechanisms underlying changes in structure and function. Vis Neurosci. 2020;37:E008.
Becker, S., Carroll, L. S., & Vinberg, F. (2020). Diabetic photoreceptors: Mechanisms underlying changes in structure and function. Visual Neuroscience, 37, E008. https://doi.org/10.1017/S0952523820000097
Becker S, Carroll LS, Vinberg F. Diabetic Photoreceptors: Mechanisms Underlying Changes in Structure and Function. Vis Neurosci. 2020 10 6;37:E008. PubMed PMID: 33019947.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic photoreceptors: Mechanisms underlying changes in structure and function. AU - Becker,Silke, AU - Carroll,Lara S, AU - Vinberg,Frans, Y1 - 2020/10/06/ PY - 2020/10/6/entrez PY - 2020/10/7/pubmed PY - 2021/10/29/medline KW - diabetes KW - electroretinogram KW - photoreceptors KW - retina SP - E008 EP - E008 JF - Visual neuroscience JO - Vis Neurosci VL - 37 N2 - Based on clinical findings, diabetic retinopathy (DR) has traditionally been defined as a retinal microvasculopathy. Retinal neuronal dysfunction is now recognized as an early event in the diabetic retina before development of overt DR. While detrimental effects of diabetes on the survival and function of inner retinal cells, such as retinal ganglion cells and amacrine cells, are widely recognized, evidence that photoreceptors in the outer retina undergo early alterations in diabetes has emerged more recently. We review data from preclinical and clinical studies demonstrating a conserved reduction of electrophysiological function in diabetic retinas, as well as evidence for photoreceptor loss. Complementing in vivo studies, we discuss the ex vivo electroretinography technique as a useful method to investigate photoreceptor function in isolated retinas from diabetic animal models. Finally, we consider the possibility that early photoreceptor pathology contributes to the progression of DR, and discuss possible mechanisms of photoreceptor damage in the diabetic retina, such as enhanced production of reactive oxygen species and other inflammatory factors whose detrimental effects may be augmented by phototransduction. SN - 1469-8714 UR - https://www.unboundmedicine.com/medline/citation/33019947/Diabetic_photoreceptors:_Mechanisms_underlying_changes_in_structure_and_function_ L2 - https://www.cambridge.org/core/product/identifier/S0952523820000097/type/journal_article DB - PRIME DP - Unbound Medicine ER -