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Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections.
Ocul Immunol Inflamm. 2020 Nov 16; 28(8):1280-1284.OI

Abstract

PURPOSE

To report bilateral follicular conjunctivitis in two confirmed Coronavirus (COVID-19) patients with the presence of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens.

PARTICIPANTS AND METHODS

Two unrelated patients with confirmed SARS-CoV-2 infection and bilateral acute conjunctivitis were examined. Conjunctival swabs were assessed for the presence of SARS-CoV-2 by quantitative real-time polymerase chain reaction (RT-PCR) and viral culture.

RESULTS

Both patients developed eye redness 3 days after the onset of COVID-19 symptoms. Slit lamp examination showed bilateral acute follicular conjunctivitis, which was resolved within 6 days. RT-PCR demonstrated the presence of viral RNA in conjunctival specimens from both eyes, which was unrelated to viral RNA from throat swabs.

CONCLUSION

SARS-CoV-2 may cause ocular manifestations such as viral conjunctivitis. Conjunctival sampling may be useful for infected patients with conjunctivitis and fever. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Lim LW
National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore, Singapore. Tan Tock Seng Hospital , Singapore.
Tan GS
Tan Tock Seng Hospital , Singapore. National Centre for Infectious Diseases , Singapore, Singapore.
Yong V
National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore, Singapore. Tan Tock Seng Hospital , Singapore.
Anderson DE
Programme in Emerging Infectious Diseases, Duke-NUS Medical School , Singapore, Singapore.
Lye DC
National Centre for Infectious Diseases , Singapore, Singapore. Programme in Emerging Infectious Diseases, Duke-NUS Medical School , Singapore, Singapore. Lee Kong Chian School of Medicine , Singapore, Singapore. Yong Loo Lin School of Medicine , Singapore, Singapore.
Young B
Tan Tock Seng Hospital , Singapore. National Centre for Infectious Diseases , Singapore, Singapore. Lee Kong Chian School of Medicine , Singapore, Singapore.
Agrawal R
National Healthcare Group Eye Institute, Tan Tock Seng Hospital , Singapore, Singapore. Tan Tock Seng Hospital , Singapore. National Centre for Infectious Diseases , Singapore, Singapore. Programme in Emerging Infectious Diseases, Duke-NUS Medical School , Singapore, Singapore. Lee Kong Chian School of Medicine , Singapore, Singapore. Yong Loo Lin School of Medicine , Singapore, Singapore. Moorfields Eye Hospital, NHS Foundation Trust , London, UK.

MeSH

AdultBetacoronavirusCOVID-19Conjunctivitis, ViralCoronavirus InfectionsEye Infections, ViralHumansIncidenceMalePandemicsPneumonia, ViralRNA, ViralReal-Time Polymerase Chain ReactionSARS-CoV-2Singapore

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

33021847

Citation

Lim, Louis W., et al. "Acute Onset of Bilateral Follicular Conjunctivitis in Two Patients With Confirmed SARS-CoV-2 Infections." Ocular Immunology and Inflammation, vol. 28, no. 8, 2020, pp. 1280-1284.
Lim LW, Tan GS, Yong V, et al. Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections. Ocul Immunol Inflamm. 2020;28(8):1280-1284.
Lim, L. W., Tan, G. S., Yong, V., Anderson, D. E., Lye, D. C., Young, B., & Agrawal, R. (2020). Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections. Ocular Immunology and Inflammation, 28(8), 1280-1284. https://doi.org/10.1080/09273948.2020.1821901
Lim LW, et al. Acute Onset of Bilateral Follicular Conjunctivitis in Two Patients With Confirmed SARS-CoV-2 Infections. Ocul Immunol Inflamm. 2020 Nov 16;28(8):1280-1284. PubMed PMID: 33021847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute Onset of Bilateral Follicular Conjunctivitis in two Patients with Confirmed SARS-CoV-2 Infections. AU - Lim,Louis W, AU - Tan,Glorijoy S, AU - Yong,Vernon, AU - Anderson,Danielle E, AU - Lye,David C, AU - Young,Barnaby, AU - Agrawal,Rupesh, Y1 - 2020/10/06/ PY - 2020/10/7/pubmed PY - 2020/11/27/medline PY - 2020/10/6/entrez KW - COVID-19 KW - Conjunctivitis KW - Coronavirus KW - SARS-COV2 SP - 1280 EP - 1284 JF - Ocular immunology and inflammation JO - Ocul Immunol Inflamm VL - 28 IS - 8 N2 - PURPOSE: To report bilateral follicular conjunctivitis in two confirmed Coronavirus (COVID-19) patients with the presence of Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) in conjunctival swab specimens. PARTICIPANTS AND METHODS: Two unrelated patients with confirmed SARS-CoV-2 infection and bilateral acute conjunctivitis were examined. Conjunctival swabs were assessed for the presence of SARS-CoV-2 by quantitative real-time polymerase chain reaction (RT-PCR) and viral culture. RESULTS: Both patients developed eye redness 3 days after the onset of COVID-19 symptoms. Slit lamp examination showed bilateral acute follicular conjunctivitis, which was resolved within 6 days. RT-PCR demonstrated the presence of viral RNA in conjunctival specimens from both eyes, which was unrelated to viral RNA from throat swabs. CONCLUSION: SARS-CoV-2 may cause ocular manifestations such as viral conjunctivitis. Conjunctival sampling may be useful for infected patients with conjunctivitis and fever. Precautionary measures are recommended when examining infected patients throughout the clinical course of the infection. SN - 1744-5078 UR - https://www.unboundmedicine.com/medline/citation/33021847/Acute_Onset_of_Bilateral_Follicular_Conjunctivitis_in_two_Patients_with_Confirmed_SARS_CoV_2_Infections_ DB - PRIME DP - Unbound Medicine ER -