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Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms.
IDCases. 2020; 22:e00975.I

Abstract

Background

Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, which may potentially be considered both GI and sensory/neurological manifestations of infection. We hope to clarify the prevalence of these symptoms and patterns of transmission within a family cluster.

Case presentation

We interviewed 7 patients via oral inquiries and a questionnaire, collecting data on subject symptoms and their durations. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to confirm 2 of these cases. We report a familial cluster of 5 presumed and 2 confirmed COVID-19 cases, all of whom reported one or more GI symptoms and 5 of whom reported sensory symptoms of anosmia/hyposmia, ageusia/hypogeusia, and/or dysgeusia.

Conclusions

This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. COVID-19 exhibits wide variation in duration, severity, and progression of symptoms, even within a familial cluster.

Authors+Show Affiliations

University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.University of Colorado School of Medicine, 13001 E. 17th Pl, Aurora, CO 80045, USA.Colorado State University, Department of Biology, 251 W. Pitkin St, Fort Collins, CO 80521, USA.Colorado College, Department of Biology, 14 E, W Cache La Poudre St, Colorado Springs, CO 80903, USA.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

33024695

Citation

Ho, Bethany E., et al. "Case Report of Familial COVID-19 Cluster Associated With High Prevalence of Anosmia, Ageusia, and Gastrointestinal Symptoms." IDCases, vol. 22, 2020, pp. e00975.
Ho BE, Ho AP, Ho MA, et al. Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms. IDCases. 2020;22:e00975.
Ho, B. E., Ho, A. P., Ho, M. A., & Ho, E. C. (2020). Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms. IDCases, 22, e00975. https://doi.org/10.1016/j.idcr.2020.e00975
Ho BE, et al. Case Report of Familial COVID-19 Cluster Associated With High Prevalence of Anosmia, Ageusia, and Gastrointestinal Symptoms. IDCases. 2020;22:e00975. PubMed PMID: 33024695.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case report of familial COVID-19 cluster associated with High prevalence of anosmia, ageusia, and gastrointestinal symptoms. AU - Ho,Bethany E, AU - Ho,Andrea P, AU - Ho,Michaela A, AU - Ho,Elizabeth C, Y1 - 2020/10/01/ PY - 2020/08/23/received PY - 2020/09/26/accepted PY - 2020/10/8/pubmed PY - 2020/10/8/medline PY - 2020/10/7/entrez KW - Ageusia KW - Anosmia KW - COVID-19 KW - COVID-19, coronavirus disease of 2019 KW - Case report KW - Family cluster KW - GI, gastrointestinal KW - RT-PCR, reverse transcriptase polymerase chain reaction KW - SARS-CoV-2 KW - SARS-CoV-2, severe acute respiratory syndrome coronavirus 2 SP - e00975 EP - e00975 JF - IDCases JO - IDCases VL - 22 N2 - Background: Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, which may potentially be considered both GI and sensory/neurological manifestations of infection. We hope to clarify the prevalence of these symptoms and patterns of transmission within a family cluster. Case presentation: We interviewed 7 patients via oral inquiries and a questionnaire, collecting data on subject symptoms and their durations. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to confirm 2 of these cases. We report a familial cluster of 5 presumed and 2 confirmed COVID-19 cases, all of whom reported one or more GI symptoms and 5 of whom reported sensory symptoms of anosmia/hyposmia, ageusia/hypogeusia, and/or dysgeusia. Conclusions: This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. COVID-19 exhibits wide variation in duration, severity, and progression of symptoms, even within a familial cluster. SN - 2214-2509 UR - https://www.unboundmedicine.com/medline/citation/33024695/Case_report_of_familial_COVID_19_cluster_associated_with_High_prevalence_of_anosmia_ageusia_and_gastrointestinal_symptoms_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2214-2509(20)30283-3 DB - PRIME DP - Unbound Medicine ER -
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