Tags

Type your tag names separated by a space and hit enter

Identification of novel mutations in SARS-COV-2 isolates from Turkey.
Arch Virol. 2020 Dec; 165(12):2937-2944.AV

Abstract

SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis revealed multiple independent sources of introductions of SARS-CoV-2 into Turkey and a close relationship to the isolates from Saudi Arabia.

Authors+Show Affiliations

Department of Botany, Rawalpindi Women University, Rawalpindi, Pakistan. shaziarehman7@gmail.com. Department of Botany, Govt. Gordon College Rawalpindi, Rawalpindi, Pakistan. shaziarehman7@gmail.com.Department of Plant Sciences, Quaid-i-Azam University, Islamabad, 45320, Pakistan.Department of Botany, GDC Khanpur, Haripur, Pakistan.University Institute of Biochemistry and Biotechnology, PMAS-UAAR, Rawalpindi, Pakistan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

33025199

Citation

Rehman, Shazia, et al. "Identification of Novel Mutations in SARS-COV-2 Isolates From Turkey." Archives of Virology, vol. 165, no. 12, 2020, pp. 2937-2944.
Rehman S, Mahmood T, Aziz E, et al. Identification of novel mutations in SARS-COV-2 isolates from Turkey. Arch Virol. 2020;165(12):2937-2944.
Rehman, S., Mahmood, T., Aziz, E., & Batool, R. (2020). Identification of novel mutations in SARS-COV-2 isolates from Turkey. Archives of Virology, 165(12), 2937-2944. https://doi.org/10.1007/s00705-020-04830-0
Rehman S, et al. Identification of Novel Mutations in SARS-COV-2 Isolates From Turkey. Arch Virol. 2020;165(12):2937-2944. PubMed PMID: 33025199.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Identification of novel mutations in SARS-COV-2 isolates from Turkey. AU - Rehman,Shazia, AU - Mahmood,Tariq, AU - Aziz,Ejaz, AU - Batool,Riffat, Y1 - 2020/10/06/ PY - 2020/07/24/received PY - 2020/09/01/accepted PY - 2020/10/8/pubmed PY - 2020/11/4/medline PY - 2020/10/7/entrez SP - 2937 EP - 2944 JF - Archives of virology JO - Arch Virol VL - 165 IS - 12 N2 - SARS-CoV-2 was first detected in the city of Wuhan, Hubei Province, China. In this study, we identified 11 unique mutations in viral SARS-COV-2 isolates from Turkey. Nine of them cause structural alterations in the S protein, nsp2, nsp3, nsp4 and nsp12 regions. The mutations identified here might have significant functional implications that need to be addressed in future studies in the context of vaccine engineering and therapeutic interventions. Moreover, transmission and phylogenetic analysis revealed multiple independent sources of introductions of SARS-CoV-2 into Turkey and a close relationship to the isolates from Saudi Arabia. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/33025199/Identification_of_novel_mutations_in_SARS_COV_2_isolates_from_Turkey_ L2 - https://dx.doi.org/10.1007/s00705-020-04830-0 DB - PRIME DP - Unbound Medicine ER -