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Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus.
BMC Cardiovasc Disord. 2020 10 07; 20(1):435.BC

Abstract

BACKGROUND

To evaluate the coronary plaque characteristics of coronary arteries using computed tomography angiography (CTA) in order to assess the risk of coronary artery disease and the relevance of high sensitivity C reactive protein (hs-CRP) in patients with Diabetes Mellitus (DM).

METHODS

The clinical data of 400 DM patients and 400 non-DM patients from January 2017 to December 2019 were collected, including the results of coronaryCTA. The plasma hs-CRP level of the two groups were divided into three groups: CRP ≤ 1, 1 < CRP ≤ 2, CRP > 2. The correlation of the degree of stenosis, the number of plaques, the nature of plaques and hs-CRP value between the two groups was evaluated.

RESULTS

Compared with non-DM patients, the incidence of coronary artery plaques and lumen stenosis in DM patients was more higher than that in non-DM patients. DM patients were more likely to have more diseased vessels, especially diffuse vascular disease (12.00% vs 1.75%; P < 0.001). Subjects with high hs-CRP levels were more likely to have any plaque compared with individuals showing normal hs-CRP levels (p<0.01). There was no statistical significance in non calcified plaque with high level of hs-CRP, but the occurrence of plaque types in DM group was statistically significant compared with other hs-CRP levels in non DM group. Subjects with high hs-CRP were observed to be at increased risk for the presence of calcified plaque and severe narrowing in the unadjusted values.

CONCLUSIONS

Coronary CTA combined with hs-CRP can accurately detect the characteristics of coronary artery stenosis and plaque in DM patients, which has an important clinical value in the risk assessment of coronary heart disease in DM patients.

Authors+Show Affiliations

Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China.Department of CT, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150086, China. jinlingzi@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33028234

Citation

Zhou, Hai-Ting, et al. "Assessment of High Sensitivity C-reactive Protein and Coronary Plaque Characteristics By Computed Tomography in Patients With and Without Diabetes Mellitus." BMC Cardiovascular Disorders, vol. 20, no. 1, 2020, p. 435.
Zhou HT, Zhao DL, Wang GK, et al. Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus. BMC Cardiovasc Disord. 2020;20(1):435.
Zhou, H. T., Zhao, D. L., Wang, G. K., Wang, T. Z., Liang, H. W., & Zhang, J. L. (2020). Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus. BMC Cardiovascular Disorders, 20(1), 435. https://doi.org/10.1186/s12872-020-01704-w
Zhou HT, et al. Assessment of High Sensitivity C-reactive Protein and Coronary Plaque Characteristics By Computed Tomography in Patients With and Without Diabetes Mellitus. BMC Cardiovasc Disord. 2020 10 7;20(1):435. PubMed PMID: 33028234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of high sensitivity C-reactive protein and coronary plaque characteristics by computed tomography in patients with and without diabetes mellitus. AU - Zhou,Hai-Ting, AU - Zhao,De-Li, AU - Wang,Guo-Kun, AU - Wang,Tian-Zuo, AU - Liang,Hong-Wei, AU - Zhang,Jin-Ling, Y1 - 2020/10/07/ PY - 2020/06/27/received PY - 2020/09/16/accepted PY - 2020/10/8/entrez PY - 2020/10/9/pubmed PY - 2021/1/26/medline KW - CT KW - Coronary Angiography KW - Diabetes KW - X-ray SP - 435 EP - 435 JF - BMC cardiovascular disorders JO - BMC Cardiovasc Disord VL - 20 IS - 1 N2 - BACKGROUND: To evaluate the coronary plaque characteristics of coronary arteries using computed tomography angiography (CTA) in order to assess the risk of coronary artery disease and the relevance of high sensitivity C reactive protein (hs-CRP) in patients with Diabetes Mellitus (DM). METHODS: The clinical data of 400 DM patients and 400 non-DM patients from January 2017 to December 2019 were collected, including the results of coronaryCTA. The plasma hs-CRP level of the two groups were divided into three groups: CRP ≤ 1, 1 < CRP ≤ 2, CRP > 2. The correlation of the degree of stenosis, the number of plaques, the nature of plaques and hs-CRP value between the two groups was evaluated. RESULTS: Compared with non-DM patients, the incidence of coronary artery plaques and lumen stenosis in DM patients was more higher than that in non-DM patients. DM patients were more likely to have more diseased vessels, especially diffuse vascular disease (12.00% vs 1.75%; P < 0.001). Subjects with high hs-CRP levels were more likely to have any plaque compared with individuals showing normal hs-CRP levels (p<0.01). There was no statistical significance in non calcified plaque with high level of hs-CRP, but the occurrence of plaque types in DM group was statistically significant compared with other hs-CRP levels in non DM group. Subjects with high hs-CRP were observed to be at increased risk for the presence of calcified plaque and severe narrowing in the unadjusted values. CONCLUSIONS: Coronary CTA combined with hs-CRP can accurately detect the characteristics of coronary artery stenosis and plaque in DM patients, which has an important clinical value in the risk assessment of coronary heart disease in DM patients. SN - 1471-2261 UR - https://www.unboundmedicine.com/medline/citation/33028234/Assessment_of_high_sensitivity_C_reactive_protein_and_coronary_plaque_characteristics_by_computed_tomography_in_patients_with_and_without_diabetes_mellitus_ L2 - https://bmccardiovascdisord.biomedcentral.com/articles/10.1186/s12872-020-01704-w DB - PRIME DP - Unbound Medicine ER -