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Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop.
Alzheimers Dement. 2020 Oct 08 [Online ahead of print]AD

Abstract

Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID.

Authors+Show Affiliations

University of Southern California, Los Angeles, California, USA.Johns Hopkins University, Baltimore, Maryland, USA.Cedars-Sinai Medical Center, Los Angeles, California, USA.University of Texas Health Science Center, San Antonio and Boston University, San Antonio, Texas, USA.VA Boston Healthcare System and Boston University, Boston, Massachusetts, USA.Alzheimer's Association, Chicago, Illinois, USA.Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.University of California, San Francisco, San Francisco, California, USA.Cornell University, Ithaca, New York, USA.University of Washington, Seattle, Washington, USA.Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.University of California San Diego, La Jolla, California, USA.Rush University, Chicago, Illinois, USA.University of British Columbia, Vancouver and Kelowna, British Columbia.Mayo Clinic, Rochester, Minnesota, USA.National Institute on Aging, Bethesda, Maryland, USA.National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.National Institute of Neurological Disorders and Stroke, Bethesda, Maryland, USA.National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

33030307

Citation

Zlokovic, Berislav V., et al. "Vascular Contributions to Cognitive Impairment and Dementia (VCID): a Report From the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2020.
Zlokovic BV, Gottesman RF, Bernstein KE, et al. Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020.
Zlokovic, B. V., Gottesman, R. F., Bernstein, K. E., Seshadri, S., McKee, A., Snyder, H., Greenberg, S. M., Yaffe, K., Schaffer, C. B., Yuan, C., Hughes, T. M., Daemen, M. J., Williamson, J. D., González, H. M., Schneider, J., Wellington, C. L., Katusic, Z. S., Stoeckel, L., Koenig, J. I., ... Chen, J. (2020). Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. https://doi.org/10.1002/alz.12157
Zlokovic BV, et al. Vascular Contributions to Cognitive Impairment and Dementia (VCID): a Report From the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. Alzheimers Dement. 2020 Oct 8; PubMed PMID: 33030307.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of Neurological Disorders and Stroke Workshop. AU - Zlokovic,Berislav V, AU - Gottesman,Rebecca F, AU - Bernstein,Kenneth E, AU - Seshadri,Sudha, AU - McKee,Ann, AU - Snyder,Heather, AU - Greenberg,Steven M, AU - Yaffe,Kristine, AU - Schaffer,Chris B, AU - Yuan,Chun, AU - Hughes,Timothy M, AU - Daemen,Mat J, AU - Williamson,Jeff D, AU - González,Hector M, AU - Schneider,Julie, AU - Wellington,Cheryl L, AU - Katusic,Zvonimir S, AU - Stoeckel,Luke, AU - Koenig,James I, AU - Corriveau,Roderick A, AU - Fine,Lawrence, AU - Galis,Zorina S, AU - Reis,Jared, AU - Wright,Jacqueline D, AU - Chen,Jue, Y1 - 2020/10/08/ PY - 2020/03/06/received PY - 2020/06/30/revised PY - 2020/06/30/accepted PY - 2020/10/9/pubmed PY - 2020/10/9/medline PY - 2020/10/8/entrez KW - Alzheimer's disease-related dementias KW - cerebrovascular and cardiovascular disease KW - vascular contributions to cognitive impairment and dementia JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement N2 - Vascular contributions to cognitive impairment and dementia (VCID) are characterized by the aging neurovascular unit being confronted with and failing to cope with biological insults due to systemic and cerebral vascular disease, proteinopathy including Alzheimer's biology, metabolic disease, or immune response, resulting in cognitive decline. This report summarizes the discussion and recommendations from a working group convened by the National Heart, Lung, and Blood Institute and the National Institute of Neurological Disorders and Stroke to evaluate the state of the field in VCID research, identify research priorities, and foster collaborations. As discussed in this report, advances in understanding the biological mechanisms of VCID across the wide spectrum of pathologies, chronic systemic comorbidities, and other risk factors may lead to potential prevention and new treatment strategies to decrease the burden of dementia. Better understanding of the social determinants of health that affect risks for both vascular disease and VCID could provide insight into strategies to reduce racial and ethnic disparities in VCID. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/33030307/Vascular_contributions_to_cognitive_impairment_and_dementia__VCID_:_A_report_from_the_2018_National_Heart_Lung_and_Blood_Institute_and_National_Institute_of_Neurological_Disorders_and_Stroke_Workshop_ L2 - https://doi.org/10.1002/alz.12157 DB - PRIME DP - Unbound Medicine ER -
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