TY - JOUR T1 - Bioactive Compounds and Pharmacological Potential of Pomegranate (Punica granatum) Seeds - A Review. AU - Fourati,Mariam, AU - Smaoui,Slim, AU - Hlima,Hajer Ben, AU - Elhadef,Khaoula, AU - Braïek,Olfa Ben, AU - Ennouri,Karim, AU - Mtibaa,Ahlem Chakchouk, AU - Mellouli,Lotfi, Y1 - 2020/10/10/ PY - 2020/10/01/accepted PY - 2020/10/12/pubmed PY - 2020/11/25/medline PY - 2020/10/11/entrez KW - Analytical chemistry KW - Bioactive compounds KW - Biological activity KW - Health benefits KW - Pomegranate seed SP - 477 EP - 486 JF - Plant foods for human nutrition (Dordrecht, Netherlands) JO - Plant Foods Hum Nutr VL - 75 IS - 4 N2 - The use of complementary medicine has recently increased in an attempt to find effective alternative therapies that reduce the adverse effects of drugs. Pomegranate (Punica granatum L.) by-products, such as seeds, is a rich source of phytochemicals with a high antioxidant activity, thus possessing health benefits. For the identification and quantification of the pomegranate seeds chemical compounds, particular attention has been drawn to the latest developments in the HPLC coupling with electrospray ionization (ESI) MS/MS detection. In fact, a wide range of phytochemicals including phenolic acid, anthocyanins, flavonoids, hydrolysable tannins and other polyphenols were characterized. Furthermore, an exhaustive review of the scientific literature on pomegranate seeds on biomedicine and pharmacotherapy was carried out. Indeed, both in vitro and in vivo studies have demonstrated how pomegranate seeds possess antioxidant, anti- cardiovascular diseases, anti-osteoporosis, antidiabetic, anti-inflammatory and anticancer activities. The present review describes a recent tendency in research focusing on the chemical and biomedical features of the pomegranate seeds to value them as natural additives or active compounds for first-order diseases. SN - 1573-9104 UR - https://www.unboundmedicine.com/medline/citation/33040298/Bioactive_Compounds_and_Pharmacological_Potential_of_Pomegranate__Punica_granatum__Seeds___A_Review_ DB - PRIME DP - Unbound Medicine ER -