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Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.
Sci Rep. 2020 10 12; 10(1):16991.SR

Abstract

Upon reactivation, consolidated memories can enter a temporary labile state and require restabilisation, known as reconsolidation. Interventions during this reconsolidation period can disrupt the reactivated memory. However, it is unclear whether different kinds of memory that depend on distinct brain regions all undergo reconsolidation. Evidence for reconsolidation originates from studies assessing amygdala-dependent memories using cue-conditioning paradigms in rodents, which were subsequently replicated in humans. Whilst studies providing evidence for reconsolidation of hippocampus-dependent memories in rodents have predominantly used context conditioning paradigms, studies in humans have used completely different paradigms such as tests for wordlists or stories. Here our objective was to bridge this paradigm gap between rodent and human studies probing reconsolidation of hippocampus-dependent memories. We modified a recently developed immersive Virtual Reality paradigm to test in humans whether contextual threat-conditioned memories can be disrupted by a reminder-extinction procedure that putatively targets reconsolidation. In contrast to our hypothesis, we found comparable recovery of contextual conditioned threat responses, and comparable retention of subjective measures of threat memory, episodic memory and exploration behaviour between the reminder-extinction and standard extinction groups. Our result provide no evidence that a reminder before extinction can prevent the return of context conditioned threat memories in humans.

Authors+Show Affiliations

Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Center, Kapittelweg 29, 6500 HB, Nijmegen, The Netherlands. m.houtekamer@donders.ru.nl.Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Center, Kapittelweg 29, 6500 HB, Nijmegen, The Netherlands.Center for Neural Science, New York University, New York, NY, 10003, USA.Department of Psychiatry, University of Texas at Austin, Austin, TX, 78712, USA.Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Center, Kapittelweg 29, 6500 HB, Nijmegen, The Netherlands.Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition, and Behaviour, Radboud University Nijmegen Medical Center, Kapittelweg 29, 6500 HB, Nijmegen, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

33046753

Citation

Houtekamer, Maxime C., et al. "Investigating the Efficacy of the Reminder-extinction Procedure to Disrupt Contextual Threat Memories in Humans Using Immersive Virtual Reality." Scientific Reports, vol. 10, no. 1, 2020, p. 16991.
Houtekamer MC, Henckens MJAG, Mackey WE, et al. Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality. Sci Rep. 2020;10(1):16991.
Houtekamer, M. C., Henckens, M. J. A. G., Mackey, W. E., Dunsmoor, J. E., Homberg, J. R., & Kroes, M. C. W. (2020). Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality. Scientific Reports, 10(1), 16991. https://doi.org/10.1038/s41598-020-73139-4
Houtekamer MC, et al. Investigating the Efficacy of the Reminder-extinction Procedure to Disrupt Contextual Threat Memories in Humans Using Immersive Virtual Reality. Sci Rep. 2020 10 12;10(1):16991. PubMed PMID: 33046753.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality. AU - Houtekamer,Maxime C, AU - Henckens,Marloes J A G, AU - Mackey,Wayne E, AU - Dunsmoor,Joseph E, AU - Homberg,Judith R, AU - Kroes,Marijn C W, Y1 - 2020/10/12/ PY - 2019/12/16/received PY - 2020/09/08/accepted PY - 2020/10/13/entrez PY - 2020/10/14/pubmed PY - 2021/1/12/medline SP - 16991 EP - 16991 JF - Scientific reports JO - Sci Rep VL - 10 IS - 1 N2 - Upon reactivation, consolidated memories can enter a temporary labile state and require restabilisation, known as reconsolidation. Interventions during this reconsolidation period can disrupt the reactivated memory. However, it is unclear whether different kinds of memory that depend on distinct brain regions all undergo reconsolidation. Evidence for reconsolidation originates from studies assessing amygdala-dependent memories using cue-conditioning paradigms in rodents, which were subsequently replicated in humans. Whilst studies providing evidence for reconsolidation of hippocampus-dependent memories in rodents have predominantly used context conditioning paradigms, studies in humans have used completely different paradigms such as tests for wordlists or stories. Here our objective was to bridge this paradigm gap between rodent and human studies probing reconsolidation of hippocampus-dependent memories. We modified a recently developed immersive Virtual Reality paradigm to test in humans whether contextual threat-conditioned memories can be disrupted by a reminder-extinction procedure that putatively targets reconsolidation. In contrast to our hypothesis, we found comparable recovery of contextual conditioned threat responses, and comparable retention of subjective measures of threat memory, episodic memory and exploration behaviour between the reminder-extinction and standard extinction groups. Our result provide no evidence that a reminder before extinction can prevent the return of context conditioned threat memories in humans. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/33046753/Investigating_the_efficacy_of_the_reminder_extinction_procedure_to_disrupt_contextual_threat_memories_in_humans_using_immersive_Virtual_Reality_ DB - PRIME DP - Unbound Medicine ER -